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Register a new userOpenClinicalAI: enabling AI to diagnose diseases in real-world clinical settings
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Yunyou Huang
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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This paper quantitatively reveals the state-of-the-art and state-of-the-practice AI systems only achieve acceptable performance on the stringent conditions that all categories of subjects are known, which we call closed clinical settings, but fail to work in real-world clinical settings. Compared to the diagnosis task in the closed setting, real-world clinical settings pose severe challenges, and we must treat them differently. We build a clinical AI benchmark named Clinical AIBench to set up real-world clinical settings to facilitate researches. We propose an open, dynamic machine learning framework and develop an AI system named OpenClinicalAI to diagnose diseases in real-world clinical settings. The fir
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An important open problem in robotic planning is the autonomous generation of 3D inspection paths -- that is, planning the best path to move a robot along in order to inspect a target structure. We recently suggested a new method for planning paths allowing the inspection of complex 3D structures, given a triangular mesh model of the structure. The method differs from previous approaches in its emphasis on generating and considering also plans that result in imperfect coverage of the inspection target. In many practical tasks, one would accept imperfections in coverage if this results in a substantially more energy efficient inspection path. The key idea is using a multiobjective evolutionary algorithm to optimize the energy usage and coverage of inspection plans simultaneously - and the result is a set of plans exploring the different ways to balance the two objectives. We here test our method on a set of inspection targets with large variation in size and complexity, and compare its performance with two state-of-the-art methods for complete coverage path planning. The results strengthen our confidence in the ability of our method to generate good inspection plans for different types of targets. The methods advantage is most clearly seen for real-world inspection targets, since traditional complete coverage methods have no good way of generating plans for structures with hidden parts. Multiobjective evolution, by optimizing energy usage and coverage together ensures a good balance between the two - both when 100% coverage is feasible, and when large parts of the object are hidden.
We introduce the Pricing Engine package to enable the use of Double ML estimation techniques in general panel data settings. Customization allows the user to specify first-stage models, first-stage featurization, second stage treatment selection and second stage causal-modeling. We also introduce a DynamicDML class that allows the user to generate dynamic treatment-aware forecasts at a range of leads and to understand how the forecasts will vary as a function of causally estimated treatment parameters. The Pricing Engine is built on Python 3.5 and can be run on an Azure ML Workbench environment with the addition of only a few Python packages. This note provides high-level discussion of the Double ML method, describes the packages intended use and includes an example Jupyter notebook demonstrating application to some publicly available data. Installation of the package and additional technical documentation is available at $href{https://github.com/bquistorff/pricingengine}{github.com/bquistorff/pricingengine}$.
Chest radiograph (CXR) interpretation in pediatric patients is error-prone and requires a high level of understanding of radiologic expertise. Recently, deep convolutional neural networks (D-CNNs) have shown remarkable performance in interpreting CXR in adults. However, there is a lack of evidence indicating that D-CNNs can recognize accurately multiple lung pathologies from pediatric CXR scans. In particular, the development of diagnostic models for the detection of pediatric chest diseases faces significant challenges such as (i) lack of physician-annotated datasets and (ii) class imbalance problems. In this paper, we retrospectively collect a large dataset of 5,017 pediatric CXR scans, for which each is manually labeled by an experienced radiologist for the presence of 10 common pathologies. A D-CNN model is then trained on 3,550 annotated scans to classify multiple pediatric lung pathologies automatically. To address the high-class imbalance issue, we propose to modify and apply Distribution-Balanced loss for training D-CNNs which reshapes the standard Binary-Cross Entropy loss (BCE) to efficiently learn harder samples by down-weighting the loss assigned to the majority classes. On an independent test set of 777 studies, the proposed approach yields an area under the receiver operating characteristic (AUC) of 0.709 (95% CI, 0.690-0.729). The sensitivity, specificity, and F1-score at the cutoff value are 0.722 (0.694-0.750), 0.579 (0.563-0.595), and 0.389 (0.373-0.405), respectively. These results significantly outperform previous state-of-the-art methods on most of the target diseases. Moreover, our ablation studies validate the effectiveness of the proposed loss function compared to other standard losses, e.g., BCE and Focal Loss, for this learning task. Overall, we demonstrate the potential of D-CNNs in interpreting pediatric CXRs.
Developing visual perception models for active agents and sensorimotor control are cumbersome to be done in the physical world, as existing algorithms are too slow to efficiently learn in real-time and robots are fragile and costly. This has given rise to learning-in-simulation which consequently casts a question on whether the results transfer to real-world. In this paper, we are concerned with the problem of developing real-world perception for active agents, propose Gibson Virtual Environment for this purpose, and showcase sample perceptual tasks learned therein. Gibson is based on virtualizing real spaces, rather than using artificially designed ones, and currently includes over 1400 floor spaces from 572 full buildings. The main characteristics of Gibson are: I. being from the real-world and reflecting its semantic complexity, II. having an internal synthesis mechanism, Goggles, enabling deploying the trained models in real-world without needing further domain adaptation, III. embodiment of agents and making them subject to constraints of physics and space.
The ability to explain decisions made by AI systems is highly sought after, especially in domains where human lives are at stake such as medicine or autonomous vehicles. While it is often possible to approximate the input-output relations of deep neural networks with a few human-understandable rules, the discovery of the double descent phenomena suggests that such approximations do not accurately capture the mechanism by which deep neural networks work. Double descent indicates that deep neural networks typically operate by smoothly interpolating between data points rather than by extracting a few high level rules. As a result, neural networks trained on complex real world data are inherently hard to interpret and prone to failure if asked to extrapolate. To show how we might be able to trust AI despite these problems we introduce the concept of self-explaining AI. Self-explaining AIs are capable of providing a human-understandable explanation of each decision along with confidence levels for both the decision and explanation. For this approach to work, it is important that the explanation actually be related to the decision, ideally capturing the mechanism used to arrive at the explanation. Finally, we argue it is important that deep learning based systems include a warning light based on techniques from applicability domain analysis to warn the user if a model is asked to extrapolate outside its training distribution. For a video presentation of this talk see https://www.youtube.com/watch?v=Py7PVdcu7WY& .
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