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Register a new userU-Net-and-a-half: Convolutional network for biomedical image segmentation using multiple expert-driven annotations
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Development of deep learning systems for biomedical segmentation often requires access to expert-driven, manually annotated datasets. If more than a single expert is involved in the annotation of the same images, then the inter-expert agreement is not necessarily perfect, and no single expert annotation can precisely capture the so-called ground truth of the regions of interest on all images. Also, it is not trivial to generate a reference estimate using annotations from multiple experts. Here we present a deep neural network, defined as U-Net-and-a-half, which can simultaneously learn from annotations performed by multiple experts on the same set of images. U-Net-and-a-half contains a convolutional encoder to generate features from the input images, multiple decoders that allow simultaneous learning from image masks obtained from annotations that were independently generated by multiple experts, and a shared low-dimensional feature space. To demonstrate the applicability of our framework, we used two distinct datasets from digital pathology and radiology, respectively. Specifically, we trained two separate models using pathologist-driven annotations of glomeruli on whole slide images of human kidney biopsies (10 patients), and radiologist-driven annotations of lumen cross-sections of human arteriovenous fistulae obtained from intravascular ultrasound images (10 patients), respectively. The models based on U-Net-and-a-half exceeded the performance of the traditional U-Net models trained on single expert annotations alone, thus expanding the scope of multitask learning in the context of biomedical image segmentation.
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With the advent of advancements in deep learning approaches, such as deep convolution neural network, residual neural network, adversarial network; U-Net architectures are most widely utilized in biomedical image segmentation to address the automation in identification and detection of the target regions or sub-regions. In recent studies, U-Net based approaches have illustrated state-of-the-art performance in different applications for the development of computer-aided diagnosis systems for early diagnosis and treatment of diseases such as brain tumor, lung cancer, alzheimer, breast cancer, etc. This article contributes to present the success of these approaches by describing the U-Net framework, followed by the comprehensive analysis of the U-Net variants for different medical imaging or modalities such as magnetic resonance imaging, X-ray, computerized tomography/computerized axial tomography, ultrasound, positron emission tomography, etc. Besides, this article also highlights the contribution of U-Net based frameworks in the on-going pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as COVID-19.
Most methods for medical image segmentation use U-Net or its variants as they have been successful in most of the applications. After a detailed analysis of these traditional encoder-decoder based approaches, we observed that they perform poorly in detecting smaller structures and are unable to segment boundary regions precisely. This issue can be attributed to the increase in receptive field size as we go deeper into the encoder. The extra focus on learning high level features causes the U-Net based approaches to learn less information about low-level features which are crucial for detecting small structures. To overcome this issue, we propose using an overcomplete convolutional architecture where we project our input image into a higher dimension such that we constrain the receptive field from increasing in the deep layers of the network. We design a new architecture for image segmentation- KiU-Net which has two branches: (1) an overcomplete convolutional network Kite-Net which learns to capture fine details and accurate edges of the input, and (2) U-Net which learns high level features. Furthermore, we also propose KiU-Net 3D which is a 3D convolutional architecture for volumetric segmentation. We perform a detailed study of KiU-Net by performing experiments on five different datasets covering various image modalities like ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT), microscopic and fundus images. The proposed method achieves a better performance as compared to all the recent methods with an additional benefit of fewer parameters and faster convergence. Additionally, we also demonstrate that the extensions of KiU-Net based on residual blocks and dense blocks result in further performance improvements. The implementation of KiU-Net can be found here: https://github.com/jeya-maria-jose/KiU-Net-pytorch
Methods based on convolutional neural networks have improved the performance of biomedical image segmentation. However, most of these methods cannot efficiently segment objects of variable sizes and train on small and biased datasets, which are common in biomedical use cases. While methods exist that incorporate multi-scale fusion approaches to address the challenges arising with variable sizes, they usually use complex models that are more suitable for general semantic segmentation computer vision problems. In this paper, we propose a novel architecture called MSRF-Net, which is specially designed for medical image segmentation tasks. The proposed MSRF-Net is able to exchange multi-scale features of varying receptive fields using a dual-scale dense fusion block (DSDF). Our DSDF block can exchange information rigorously across two different resolution scales, and our MSRF sub-network uses multiple DSDF blocks in sequence to perform multi-scale fusion. This allows the preservation of resolution, improved information flow, and propagation of both high- and low-level features to obtain accurate segmentation maps. The proposed MSRF-Net allows to capture object variabilities and provides improved results on different biomedical datasets. Extensive experiments on MSRF-Net demonstrate that the proposed method outperforms most of the cutting-edge medical image segmentation state-of-the-art methods. MSRF-Net advances the performance on four publicly available datasets, and also, MSRF-Net is more generalizable as compared to state-of-the-art methods.
Semantic image segmentation is the process of labeling each pixel of an image with its corresponding class. An encoder-decoder based approach, like U-Net and its variants, is a popular strategy for solving medical image segmentation tasks. To improve the performance of U-Net on various segmentation tasks, we propose a novel architecture called DoubleU-Net, which is a combination of two U-Net architectures stacked on top of each other. The first U-Net uses a pre-trained VGG-19 as the encoder, which has already learned features from ImageNet and can be transferred to another task easily. To capture more semantic information efficiently, we added another U-Net at the bottom. We also adopt Atrous Spatial Pyramid Pooling (ASPP) to capture contextual information within the network. We have evaluated DoubleU-Net using four medical segmentation datasets, covering various imaging modalities such as colonoscopy, dermoscopy, and microscopy. Experiments on the MICCAI 2015 segmentation challenge, the CVC-ClinicDB, the 2018 Data Science Bowl challenge, and the Lesion boundary segmentation datasets demonstrate that the DoubleU-Net outperforms U-Net and the baseline models. Moreover, DoubleU-Net produces more accurate segmentation masks, especially in the case of the CVC-ClinicDB and MICCAI 2015 segmentation challenge datasets, which have challenging images such as smaller and flat polyps. These results show the improvement over the existing U-Net model. The encouraging results, produced on various medical image segmentation datasets, show that DoubleU-Net can be used as a strong baseline for both medical image segmentation and cross-dataset evaluation testing to measure the generalizability of Deep Learning (DL) models.
The Medico: Multimedia Task 2020 focuses on developing an efficient and accurate computer-aided diagnosis system for automatic segmentation [3]. We participate in task 1, Polyps segmentation task, which is to develop algorithms for segmenting polyps on a comprehensive dataset. In this task, we propose methods combining Residual module, Inception module, Adaptive Convolutional neural network with U-Net model, and PraNet for semantic segmentation of various types of polyps in endoscopic images. We select 5 runs with different architecture and parameters in our methods. Our methods show potential results in accuracy and efficiency through multiple experiments, and our team is in the Top 3 best results with a Jaccard index of 0.765.
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