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Segmentation-free Heart Pathology Detection Using Deep Learning

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 Added by Erika Bondareva
 Publication date 2021
and research's language is English




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Cardiovascular (CV) diseases are the leading cause of death in the world, and auscultation is typically an essential part of a cardiovascular examination. The ability to diagnose a patient based on their heart sounds is a rather difficult skill to master. Thus, many approaches for automated heart auscultation have been explored. However, most of the previously proposed methods involve a segmentation step, the performance of which drops significantly for high pulse rates or noisy signals. In this work, we propose a novel segmentation-free heart sound classification method. Specifically, we apply discrete wavelet transform to denoise the signal, followed by feature extraction and feature reduction. Then, Support Vector Machines and Deep Neural Networks are utilised for classification. On the PASCAL heart sound dataset our approach showed superior performance compared to others, achieving 81% and 96% precision on normal and murmur classes, respectively. In addition, for the first time, the data were further explored under a user-independent setting, where the proposed method achieved 92% and 86% precision on normal and murmur, demonstrating the potential of enabling automatic murmur detection for practical use.



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Traditionally, abnormal heart sound classification is framed as a three-stage process. The first stage involves segmenting the phonocardiogram to detect fundamental heart sounds; after which features are extracted and classification is performed. Some researchers in the field argue the segmentation step is an unwanted computational burden, whereas others embrace it as a prior step to feature extraction. When comparing accuracies achieved by studies that have segmented heart sounds before analysis with those who have overlooked that step, the question of whether to segment heart sounds before feature extraction is still open. In this study, we explicitly examine the importance of heart sound segmentation as a prior step for heart sound classification, and then seek to apply the obtained insights to propose a robust classifier for abnormal heart sound detection. Furthermore, recognizing the pressing need for explainable Artificial Intelligence (AI) models in the medical domain, we also unveil hidden representations learned by the classifier using model interpretation techniques. Experimental results demonstrate that the segmentation plays an essential role in abnormal heart sound classification. Our new classifier is also shown to be robust, stable and most importantly, explainable, with an accuracy of almost 100% on the widely used PhysioNet dataset.
Cardiovascular diseases are the leading cause of deaths and severely threaten human health in daily life. On the one hand, there have been dramatically increasing demands from both the clinical practice and the smart home application for monitoring the heart status of subjects suffering from chronic cardiovascular diseases. On the other hand, experienced physicians who can perform an efficient auscultation are still lacking in terms of number. Automatic heart sound classification leveraging the power of advanced signal processing and machine learning technologies has shown encouraging results. Nevertheless, human hand-crafted features are expensive and time-consuming. To this end, we propose a novel deep representation learning method with an attention mechanism for heart sound classification. In this paradigm, high-level representations are learnt automatically from the recorded heart sound data. Particularly, a global attention pooling layer improves the performance of the learnt representations by estimating the contribution of each unit in feature maps. The Heart Sounds Shenzhen (HSS) corpus (170 subjects involved) is used to validate the proposed method. Experimental results validate that, our approach can achieve an unweighted average recall of 51.2% for classifying three categories of heart sounds, i. e., normal, mild, and moderate/severe annotated by cardiologists with the help of Echocardiography.
We present an experimental investigation into the effectiveness of transfer learning and bottleneck feature extraction in detecting COVID-19 from audio recordings of cough, breath and speech. This type of screening is non-contact, does not require specialist medical expertise or laboratory facilities and can be deployed on inexpensive consumer hardware. We use datasets that contain recordings of coughing, sneezing, speech and other noises, but do not contain COVID-19 labels, to pre-train three deep neural networks: a CNN, an LSTM and a Resnet50. These pre-trained networks are subsequently either fine-tuned using smaller datasets of coughing with COVID-19 labels in the process of transfer learning, or are used as bottleneck feature extractors. Results show that a Resnet50 classifier trained by this transfer learning process delivers optimal or near-optimal performance across all datasets achieving areas under the receiver operating characteristic (ROC AUC) of 0.98, 0.94 and 0.92 respectively for all three sound classes (coughs, breaths and speech). This indicates that coughs carry the strongest COVID-19 signature, followed by breath and speech. Our results also show that applying transfer learning and extracting bottleneck features using the larger datasets without COVID-19 labels led not only to improve performance, but also to minimise the standard deviation of the classifier AUCs among the outer folds of the leave-$p$-out cross-validation, indicating better generalisation. We conclude that deep transfer learning and bottleneck feature extraction can improve COVID-19 cough, breath and speech audio classification, yielding automatic classifiers with higher accuracy.
Music generation is always interesting in a sense that there is no formalized recipe. In this work, we propose a novel dual-track architecture for generating classical piano music, which is able to model the inter-dependency of left-hand and right-hand piano music. Particularly, we experimented with a lot of different models of neural network as well as different representations of music, and the results show that our proposed model outperforms all other tested methods. Besides, we deployed some special policies for model training and generation, which contributed to the model performance remarkably. Finally, under two evaluation methods, we compared our models with the MuseGAN project and true music.
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For centuries researchers have used sound to monitor and study wildlife. Traditionally, conservationists have identified species by ear; however, it is now common to deploy audio recording technology to monitor animal and ecosystem sounds. Animals use sound for communication, mating, navigation and territorial defence. Animal sounds provide valuable information and help conservationists to quantify biodiversity. Acoustic monitoring has grown in popularity due to the availability of diverse sensor types which include camera traps, portable acoustic sensors, passive acoustic sensors, and even smartphones. Passive acoustic sensors are easy to deploy and can be left running for long durations to provide insights on habitat and the sounds made by animals and illegal activity. While this technology brings enormous benefits, the amount of data that is generated makes processing a time-consuming process for conservationists. Consequently, there is interest among conservationists to automatically process acoustic data to help speed up biodiversity assessments. Processing these large data sources and extracting relevant sounds from background noise introduces significant challenges. In this paper we outline an approach for achieving this using state of the art in machine learning to automatically extract features from time-series audio signals and modelling deep learning models to classify different bird species based on the sounds they make. The acquired bird songs are processed using mel-frequency cepstrum (MFC) to extract features which are later classified using a multilayer perceptron (MLP). Our proposed method achieved promising results with 0.74 sensitivity, 0.92 specificity and an accuracy of 0.74.

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