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Register a new userArtificial Intelligence in PET: an Industry Perspective
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Added by
Arkadiusz Sitek
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Artificial intelligence (AI) has significant potential to positively impact and advance medical imaging, including positron emission tomography (PET) imaging applications. AI has the ability to enhance and optimize all aspects of the PET imaging chain from patient scheduling, patient setup, protocoling, data acquisition, detector signal processing, reconstruction, image processing and interpretation. AI poses industry-specific challenges which will need to be addressed and overcome to maximize the future potentials of AI in PET. This paper provides an overview of these industry-specific challenges for the development, standardization, commercialization, and clinical adoption of AI, and explores the potential enhancements to PET imaging brought on by AI in the near future. In particular, the combination of on-demand image reconstruction, AI, and custom designed data processing workflows may open new possibilities for innovation which would positively impact the industry and ultimately patients.
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As machine learning (ML) systems take a more prominent and central role in contributing to life-impacting decisions, ensuring their trustworthiness and accountability is of utmost importance. Explanations sit at the core of these desirable attributes of a ML system. The emerging field is frequently called ``Explainable AI (XAI) or ``Explainable ML. The goal of explainable ML is to intuitively explain the predictions of a ML system, while adhering to the needs to various stakeholders. Many explanation techniques were developed with contributions from both academia and industry. However, there are several existing challenges that have not garnered enough interest and serve as roadblocks to widespread adoption of explainable ML. In this short paper, we enumerate challenges in explainable ML from an industry perspective. We hope these challenges will serve as promising future research directions, and would contribute to democratizing explainable ML.
Principles of modern cyber-physical system (CPS) analysis are based on analytical methods that depend on whether safety or liveness requirements are considered. Complexity is abstracted through different techniques, ranging from stochastic modelling to contracts. However, both distributed heuristics and Artificial Intelligence (AI)-based approaches as well as the user perspective or unpredictable effects, such as accidents or the weather, introduce enough uncertainty to warrant reinforcement-learning-based approaches. This paper compares traditional approaches in the domain of CPS modelling and analysis with the AI researcher perspective to exploring unknown complex systems.
The rise of Artificial Intelligence (AI) will bring with it an ever-increasing willingness to cede decision-making to machines. But rather than just giving machines the power to make decisions that affect us, we need ways to work cooperatively with AI systems. There is a vital need for research in AI and Cooperation that seeks to understand the ways in which systems of AIs and systems of AIs with people can engender cooperative behavior. Trust in AI is also key: trust that is intrinsic and trust that can only be earned over time. Here we use the term AI in its broadest sense, as employed by the recent 20-Year Community Roadmap for AI Research (Gil and Selman, 2019), including but certainly not limited to, recent advances in deep learning. With success, cooperation between humans and AIs can build society just as human-human cooperation has. Whether coming from an intrinsic willingness to be helpful, or driven through self-interest, human societies have grown strong and the human species has found success through cooperation. We cooperate in the small -- as family units, with neighbors, with co-workers, with strangers -- and in the large as a global community that seeks cooperative outcomes around questions of commerce, climate change, and disarmament. Cooperation has evolved in nature also, in cells and among animals. While many cases involving cooperation between humans and AIs will be asymmetric, with the human ultimately in control, AI systems are growing so complex that, even today, it is impossible for the human to fully comprehend their reasoning, recommendations, and actions when functioning simply as passive observers.
Background: An increasing volume of prostate biopsies and a world-wide shortage of uro-pathologists puts a strain on pathology departments. Additionally, the high intra- and inter-observer variability in grading can result in over- and undertreatment of prostate cancer. Artificial intelligence (AI) methods may alleviate these problems by assisting pathologists to reduce workload and harmonize grading. Methods: We digitized 6,682 needle biopsies from 976 participants in the population based STHLM3 diagnostic study to train deep neural networks for assessing prostate biopsies. The networks were evaluated by predicting the presence, extent, and Gleason grade of malignant tissue for an independent test set comprising 1,631 biopsies from 245 men. We additionally evaluated grading performance on 87 biopsies individually graded by 23 experienced urological pathologists from the International Society of Urological Pathology. We assessed discriminatory performance by receiver operating characteristics (ROC) and tumor extent predictions by correlating predicted millimeter cancer length against measurements by the reporting pathologist. We quantified the concordance between grades assigned by the AI and the expert urological pathologists using Cohens kappa. Results: The performance of the AI to detect and grade cancer in prostate needle biopsy samples was comparable to that of international experts in prostate pathology. The AI achieved an area under the ROC curve of 0.997 for distinguishing between benign and malignant biopsy cores, and 0.999 for distinguishing between men with or without prostate cancer. The correlation between millimeter cancer predicted by the AI and assigned by the reporting pathologist was 0.96. For assigning Gleason grades, the AI achieved an average pairwise kappa of 0.62. This was within the range of the corresponding values for the expert pathologists (0.60 to 0.73).
The construction of effective Recommender Systems (RS) is a complex process, mainly due to the nature of RSs which involves large scale software-systems and human interactions. Iterative development processes require deep understanding of a current baseline as well as the ability to estimate the impact of changes in multiple variables of interest. Simulations are well suited to address both challenges and potentially leading to a high velocity construction process, a fundamental requirement in commercial contexts. Recently, there has been significant interest in RS Simulation Platforms, which allow RS developers to easily craft simulated environments where their systems can be analysed. In this work we discuss how simulations help to increase velocity, we look at the literature around RS Simulation Platforms, analyse strengths and gaps and distill a set of guiding principles for the design of RS Simulation Platforms that we believe will maximize the velocity of iterative RS construction processes.
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