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Register a new userDynamic imaging and characterization of volatile aerosols in e-cigarette emissions using deep learning-based holographic microscopy
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Various volatile aerosols have been associated with adverse health effects; however, characterization of these aerosols is challenging due to their dynamic nature. Here we present a method that directly measures the volatility of particulate matter (PM) using computational microscopy and deep learning. This method was applied to aerosols generated by electronic cigarettes (e-cigs), which vaporize a liquid mixture (e-liquid) that mainly consists of propylene glycol (PG), vegetable glycerin (VG), nicotine, and flavoring compounds. E-cig generated aerosols were recorded by a field-portable computational microscope, using an impaction-based air sampler. A lensless digital holographic microscope inside this mobile device continuously records the inline holograms of the collected particles. A deep learning-based algorithm is used to automatically reconstruct the microscopic images of e-cig generated particles from their holograms, and rapidly quantify their volatility. To evaluate the effects of e-liquid composition on aerosol dynamics, we measured the volatility of the particles generated by flavorless, nicotine-free e-liquids with various PG/VG volumetric ratios, revealing a negative correlation between the particles volatility and the volumetric ratio of VG in the e-liquid. For a given PG/VG composition, the addition of nicotine dominated the evaporation dynamics of the e-cig aerosol and the aforementioned negative correlation was no longer observed. We also revealed that flavoring additives in e-liquids significantly decrease the volatility of e-cig aerosol. The presented holographic volatility measurement technique and the associated mobile device might provide new insights on the volatility of e-cig generated particles and can be applied to characterize various volatile PM.
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Polarized light microscopy provides high contrast to birefringent specimen and is widely used as a diagnostic tool in pathology. However, polarization microscopy systems typically operate by analyzing images collected from two or more light paths in different states of polarization, which lead to relatively complex optical designs, high system costs or experienced technicians being required. Here, we present a deep learning-based holographic polarization microscope that is capable of obtaining quantitative birefringence retardance and orientation information of specimen from a phase recovered hologram, while only requiring the addition of one polarizer/analyzer pair to an existing holographic imaging system. Using a deep neural network, the reconstructed holographic images from a single state of polarization can be transformed into images equivalent to those captured using a single-shot computational polarized light microscope (SCPLM). Our analysis shows that a trained deep neural network can extract the birefringence information using both the sample specific morphological features as well as the holographic amplitude and phase distribution. To demonstrate the efficacy of this method, we tested it by imaging various birefringent samples including e.g., monosodium urate (MSU) and triamcinolone acetonide (TCA) crystals. Our method achieves similar results to SCPLM both qualitatively and quantitatively, and due to its simpler optical design and significantly larger field-of-view, this method has the potential to expand the access to polarization microscopy and its use for medical diagnosis in resource limited settings.
We introduce a new modality for dynamic phase imaging in confocal microscopy based on synthetic optical holography. By temporal demultiplexing of the detector signal into a series of holograms, we record time-resolved phase images directly in the time domain at a bandwidth as determined by the photo detector and digitizer. We demonstrate our method by optical imaging of transient vibrations in an atomic force microscope cantilever with 100 ns time resolution, and observe the dynamic deformation of the cantilever surface after excitation with broadband mechanical pulses. Temporal Fourier transform of a single data set acquired in 4.2 minutes yields frequency and mode profile of all excited out-of-plane vibration modes with sub-picometer vertical sensitivity and sub-micrometer lateral resolution. Our method has the potential for transient and spectroscopic vibration imaging of micromechanical systems at nano- and picosecond scale time resolution.
Typical large-scale recommender systems use deep learning models that are stored on a large amount of DRAM. These models often rely on embeddings, which consume most of the required memory. We present Bandana, a storage system that reduces the DRAM footprint of embeddings, by using Non-volatile Memory (NVM) as the primary storage medium, with a small amount of DRAM as cache. The main challenge in storing embeddings on NVM is its limited read bandwidth compared to DRAM. Bandana uses two primary techniques to address this limitation: first, it stores embedding vectors that are likely to be read together in the same physical location, using hypergraph partitioning, and second, it decides the number of embedding vectors to cache in DRAM by simulating dozens of small caches. These techniques allow Bandana to increase the effective read bandwidth of NVM by 2-3x and thereby significantly reduce the total cost of ownership.
Advanced microscopy and/or spectroscopy tools play indispensable role in nanoscience and nanotechnology research, as it provides rich information about the growth mechanism, chemical compositions, crystallography, and other important physical and chemical properties. However, the interpretation of imaging data heavily relies on the intuition of experienced researchers. As a result, many of the deep graphical features obtained through these tools are often unused because of difficulties in processing the data and finding the correlations. Such challenges can be well addressed by deep learning. In this work, we use the optical characterization of two-dimensional (2D) materials as a case study, and demonstrate a neural-network-based algorithm for the material and thickness identification of exfoliated 2D materials with high prediction accuracy and real-time processing capability. Further analysis shows that the trained network can extract deep graphical features such as contrast, color, edges, shapes, segment sizes and their distributions, based on which we develop an ensemble approach topredict the most relevant physical properties of 2D materials. Finally, a transfer learning technique is applied to adapt the pretrained network to other applications such as identifying layer numbers of a new 2D material, or materials produced by a different synthetic approach. Our artificial-intelligence-based material characterization approach is a powerful tool that would speed up the preparation, initial characterization of 2D materials and other nanomaterials and potentially accelerate new material discoveries.
In this paper we present an end-to-end framework for addressing the problem of dynamic pricing (DP) on E-commerce platform using methods based on deep reinforcement learning (DRL). By using four groups of different business data to represent the states of each time period, we model the dynamic pricing problem as a Markov Decision Process (MDP). Compared with the state-of-the-art DRL-based dynamic pricing algorithms, our approaches make the following three contributions. First, we extend the discrete set problem to the continuous price set. Second, instead of using revenue as the reward function directly, we define a new function named difference of revenue conversion rates (DRCR). Third, the cold-start problem of MDP is tackled by pre-training and evaluation using some carefully chosen historical sales data. Our approaches are evaluated by both offline evaluation method using real dataset of Alibaba Inc., and online field experiments starting from July 2018 with thousands of items, lasting for months on Tmall.com. To our knowledge, there is no other DP field experiment using DRL before. Field experiment results suggest that DRCR is a more appropriate reward function than revenue, which is widely used by current literature. Also, continuous price sets have better performance than discrete sets and our approaches significantly outperformed the manual pricing by operation experts.
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