No Arabic abstract
Hypoxemia, a medical condition that occurs when the blood is not carrying enough oxygen to adequately supply the tissues, is a leading indicator for dangerous complications of respiratory diseases like asthma, COPD, and COVID-19. While purpose-built pulse oximeters can provide accurate blood-oxygen saturation (SpO$_2$) readings that allow for diagnosis of hypoxemia, enabling this capability in unmodified smartphone cameras via a software update could give more people access to important information about their health, as well as improve physicians ability to remotely diagnose and treat respiratory conditions. In this work, we take a step towards this goal by performing the first clinical development validation on a smartphone-based SpO$_2$ sensing system using a varied fraction of inspired oxygen (FiO$_2$) protocol, creating a clinically relevant validation dataset for solely smartphone-based methods on a wide range of SpO$_2$ values (70%-100%) for the first time. This contrasts with previous studies, which evaluated performance on a far smaller range (85%-100%). We build a deep learning model using this data to demonstrate accurate reporting of SpO$_2$ level with an overall MAE=5.00% SpO$_2$ and identifying positive cases of low SpO$_2$<90% with 81% sensitivity and 79% specificity. We ground our analysis with a summary of recent literature in smartphone-based SpO2 monitoring, and we provide the data from the FiO$_2$ study in open-source format, so that others may build on this work.
Continuous, ubiquitous monitoring through wearable sensors has the potential to collect useful information about users context. Heart rate is an important physiologic measure used in a wide variety of applications, such as fitness tracking and health monitoring. However, wearable sensors that monitor heart rate, such as smartwatches and electrocardiogram (ECG) patches, can have gaps in their data streams because of technical issues (e.g., bad wireless channels, battery depletion, etc.) or user-related reasons (e.g. motion artifacts, user compliance, etc.). The ability to use other available sensor data (e.g., smartphone data) to estimate missing heart rate readings is useful to cope with any such gaps, thus improving data quality and continuity. In this paper, we test the feasibility of estimating raw heart rate using smartphone sensor data. Using data generated by 12 participants in a one-week study period, we were able to build both personalized and generalized models using regression, SVM, and random forest algorithms. All three algorithms outperformed the baseline moving-average interpolation method for both personalized and generalized settings. Moreover, our findings suggest that personalized models outperformed the generalized models, which speaks to the importance of considering personal physiology, behavior, and life style in the estimation of heart rate. The promising results provide preliminary evidence of the feasibility of combining smartphone sensor data with wearable sensor data for continuous heart rate monitoring.
Bipolar disorder (BPD) is a chronic mental illness characterized by extreme mood and energy changes from mania to depression. These changes drive behaviors that often lead to devastating personal or social consequences. BPD is managed clinically with regular interactions with care providers, who assess mood, energy levels, and the form and content of speech. Recent work has proposed smartphones for monitoring mood using speech. However, these works do not predict when to intervene. Predicting when to intervene is challenging because there is not a single measure that is relevant for every person: different individuals may have different levels of symptom severity considered typical. Additionally, this typical mood, or baseline, may change over time, making a single symptom threshold insufficient. This work presents an innovative approach that expands clinical mood monitoring to predict when interventions are necessary using an anomaly detection framework, which we call Temporal Normalization. We first validate the model using a dataset annotated for clinical interventions and then incorporate this method in a deep learning framework to predict mood anomalies from natural, unstructured, telephone speech data. The combination of these approaches provides a framework to enable real-world speech-focused mood monitoring.
The ubiquity of smartphone usage in many peoples lives make it a rich source of information about a persons mental and cognitive state. In this work we analyze 12 weeks of phone usage data from 113 older adults, 31 with diagnosed cognitive impairment and 82 without. We develop structured models of users smartphone interactions to reveal differences in phone usage patterns between people with and without cognitive impairment. In particular, we focus on inferring specific types of phone usage sessions that are predictive of cognitive impairment. Our model achieves an AUROC of 0.79 when discriminating between healthy and symptomatic subjects, and its interpretability enables novel insights into which aspects of phone usage strongly relate with cognitive health in our dataset.
Despite widespread use of smartphones, there is no measurement standard targeted at smartphone security behaviors. In this paper we translate a well-known cybersecurity behavioral scale into the smartphone domain and show that we can improve on this translation by following an established psychometrics approach surveying 1011 participants. We design a new 14-item Smartphone Security Behavioral Scale (SSBS) exhibiting high reliability and good fit to a two-component behavioural model based on technical versus social protection strategies. We then demonstrate how SSBS can be applied to measure the influence of mental health issues on smartphone security behavior intentions. We found significant correlations that predict SSBS profiles from three types of MHIs. Conversely, we are able to predict presence of MHIs using SSBS profiles.We obtain prediction AUCs of 72.1% for Internet addiction,75.8% for depression and 66.2% for insomnia.
We present an end-to-end model using streaming physiological time series to accurately predict near-term risk for hypoxemia, a rare, but life-threatening condition known to cause serious patient harm during surgery. Our proposed model makes inference on both hypoxemia outcomes and future input sequences, enabled by a joint sequence autoencoder that simultaneously optimizes a discriminative decoder for label prediction, and two auxiliary decoders trained for data reconstruction and forecast, which seamlessly learns future-indicative latent representation. All decoders share a memory-based encoder that helps capture the global dynamics of patient data. In a large surgical cohort of 73,536 surgeries at a major academic medical center, our model outperforms all baselines and gives a large performance gain over the state-of-the-art hypoxemia prediction system. With a high sensitivity cutoff at 80%, it presents 99.36% precision in predicting hypoxemia and 86.81% precision in predicting the much more severe and rare hypoxemic condition, persistent hypoxemia. With exceptionally low rate of false alarms, our proposed model is promising in improving clinical decision making and easing burden on the health system.