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Register a new userModeling and simulation of nuclear architecture reorganization process using a phase field approach
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Added by
Qing Cheng
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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We develop a special phase field/diffusive interface method to model the nuclear architecture reorganization process. In particular, we use a Lagrange multiplier approach in the phase field model to preserve the specific physical and geometrical constraints for the biological events. We develop several efficient and robust linear and weakly nonlinear schemes for this new model. To validate the model and numerical methods, we present ample numerical simulations which in particular reproduce several processes of nuclear architecture reorganization from the experiment literature.
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We introduce a phase-field method for continuous modeling of cracks with frictional contacts. Compared with standard discrete methods for frictional contacts, the phase-field method has two attractive features: (1) it can represent arbitrary crack geometry without an explicit function or basis enrichment, and (2) it does not require an algorithm for imposing contact constraints. The first feature, which is common in phase-field models of fracture, is attained by regularizing a sharp interface geometry using a surface density functional. The second feature, which is a unique advantage for contact problems, is achieved by a new approach that calculates the stress tensor in the regularized interface region depending on the contact condition of the interface. Particularly, under a slip condition, this approach updates stress components in the slip direction using a standard contact constitutive law, while making other stress components compatible with stress in the bulk region to ensure non-penetrating deformation in other directions. We verify the proposed phase-field method using stationary interface problems simulated by discrete methods in the literature. Subsequently, by allowing the phase field to evolve according to brittle fracture theory, we demonstrate the proposed methods capability for modeling crack growth with frictional contact.
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