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Adversarial Regression Learning for Bone Age Estimation

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 Added by Youshan Zhang
 Publication date 2021
and research's language is English




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Estimation of bone age from hand radiographs is essential to determine skeletal age in diagnosing endocrine disorders and depicting the growth status of children. However, existing automatic methods only apply their models to test images without considering the discrepancy between training samples and test samples, which will lead to a lower generalization ability. In this paper, we propose an adversarial regression learning network (ARLNet) for bone age estimation. Specifically, we first extract bone features from a fine-tuned Inception V3 neural network and propose regression percentage loss for training. To reduce the discrepancy between training and test data, we then propose adversarial regression loss and feature reconstruction loss to guarantee the transition from training data to test data and vice versa, preserving invariant features from both training and test data. Experimental results show that the proposed model outperforms state-of-the-art methods.



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Computer vision researchers prefer to estimate age from face images because facial features provide useful information. However, estimating age from face images becomes challenging when people are distant from the camera or occluded. A persons gait is a unique biometric feature that can be perceived efficiently even at a distance. Thus, gait can be used to predict age when face images are not available. However, existing gait-based classification or regression methods ignore the ordinal relationship of different ages, which is an important clue for age estimation. This paper proposes an ordinal distribution regression with a global and local convolutional neural network for gait-based age estimation. Specifically, we decompose gait-based age regression into a series of binary classifications to incorporate the ordinal age information. Then, an ordinal distribution loss is proposed to consider the inner relationships among these classifications by penalizing the distribution discrepancy between the estimated value and the ground truth. In addition, our neural network comprises a global and three local sub-networks, and thus, is capable of learning the global structure and local details from the head, body, and feet. Experimental results indicate that the proposed approach outperforms state-of-the-art gait-based age estimation methods on the OULP-Age dataset.
Bone age assessment (BAA) is clinically important as it can be used to diagnose endocrine and metabolic disorders during child development. Existing deep learning based methods for classifying bone age use the global image as input, or exploit local information by annotating extra bounding boxes or key points. However, training with the global image underutilizes discriminative local information, while providing extra annotations is expensive and subjective. In this paper, we propose an attention-guided approach to automatically localize the discriminative regions for BAA without any extra annotations. Specifically, we first train a classification model to learn the attention maps of the discriminative regions, finding the hand region, the most discriminative region (the carpal bones), and the next most discriminative region (the metacarpal bones). Guided by those attention maps, we then crop the informative local regions from the original image and aggregate different regions for BAA. Instead of taking BAA as a general regression task, which is suboptimal due to the label ambiguity problem in the age label space, we propose using joint age distribution learning and expectation regression, which makes use of the ordinal relationship among hand images with different individual ages and leads to more robust age estimation. Extensive experiments are conducted on the RSNA pediatric bone age data set. Using no training annotations, our method achieves competitive results compared with existing state-of-the-art semi-automatic deep learning-based methods that require manual annotation. Code is available at https: //github.com/chenchao666/Bone-Age-Assessment.
108 - Eric Wu , Bin Kong , Xin Wang 2018
Computerized automatic methods have been employed to boost the productivity as well as objectiveness of hand bone age assessment. These approaches make predictions according to the whole X-ray images, which include other objects that may introduce distractions. Instead, our framework is inspired by the clinical workflow (Tanner-Whitehouse) of hand bone age assessment, which focuses on the key components of the hand. The proposed framework is composed of two components: a Mask R-CNN subnet of pixelwise hand segmentation and a residual attention network for hand bone age assessment. The Mask R-CNN subnet segments the hands from X-ray images to avoid the distractions of other objects (e.g., X-ray tags). The hierarchical attention components of the residual attention subnet force our network to focus on the key components of the X-ray images and generate the final predictions as well as the associated visual supports, which is similar to the assessment procedure of clinicians. We evaluate the performance of the proposed pipeline on the RSNA pediatric bone age dataset and the results demonstrate its superiority over the previous methods.
Although impressive results have been achieved for age progression and regression, there remain two major issues in generative adversarial networks (GANs)-based methods: 1) conditional GANs (cGANs)-based methods can learn various effects between any two age groups in a single model, but are insufficient to characterize some specific patterns due to completely shared convolutions filters; and 2) GANs-based methods can, by utilizing several models to learn effects independently, learn some specific patterns, however, they are cumbersome and require age label in advance. To address these deficiencies and have the best of both worlds, this paper introduces a dropout-like method based on GAN~(RoutingGAN) to route different effects in a high-level semantic feature space. Specifically, we first disentangle the age-invariant features from the input face, and then gradually add the effects to the features by residual routers that assign the convolution filters to different age groups by dropping out the outputs of others. As a result, the proposed RoutingGAN can simultaneously learn various effects in a single model, with convolution filters being shared in part to learn some specific effects. Experimental results on two benchmarked datasets demonstrate superior performance over existing methods both qualitatively and quantitatively.
Bone age assessment is an important clinical trial to measure skeletal child maturity and diagnose of growth disorders. Conventional approaches such as the Tanner-Whitehouse (TW) and Greulich and Pyle (GP) may not perform well due to their large inter-observer and intra-observer variations. In this paper, we propose a finger joint localization strategy to filter out most non-informative parts of images. When combining with the conventional full image-based deep network, we observe a much-improved performance. % Our approach utilizes full hand and specific joints images for skeletal maturity prediction. In this study, we applied powerful deep neural network and explored a process in the forecast of skeletal bone age with the specifically combine joints images to increase the performance accuracy compared with the whole hand images.
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