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Register a new userQuantitative Hemodynamics in Aortic Dissection: Comparing in vitro MRI with FSI Simulation in a Compliant Model
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The analysis of quantitative hemodynamics and luminal pressure may add valuable information to aid treatment strategies and prognosis for aortic dissections. This work directly compared in vitro 4D-flow magnetic resonance imaging (MRI), catheter-based pressure measurements, and computational fluid dynamics that integrated fluid-structure interaction (CFD FSI). Experimental data was acquired with a compliant 3D-printed model of a type-B aortic dissection (TBAD) that was embedded into a physiologically tuned flow circuit. In vitro flow and pressure information were used to tune the CFD FSI Windkessel boundary conditions. Results showed very good overall agreement of complex flow patterns, true to false lumen flow splits, and pressure distribution. This work demonstrates feasibility of a tunable experimental setup that integrates a patient-specific compliant model and provides a test bed for exploring critical imaging and modeling parameters that ultimately may improve the prognosis for patients with aortic dissections.
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The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly individuals or because of particular pathologies, the valve leaflets can stiffen thus impairing the valve functioning and, in turn, the pumping efficiency of the heart. Using a multi-physics left heart model accounting for the electrophysiology, the active contraction of the myocardium, the hemodynamics and the related fluid-structure-interaction, we have investigated the changes in the flow features for different severities of the aortic valve stenosis. We have found that, in addition to the increase of the transvalvular pressure drop and of the systolic jet velocity, a stenotic aortic valve significantly alters the wall shear stresses and their spatial distribution over the aortic arch and valve leaflets, which may induce a remodelling process of the ventricular myocardium. The numerical results from the multi-physics model are fully consistent with the clinical experience, thus further opening the way for computational engineering aided medical diagnostic.
Motivated by problems arising in the pneumatic actuation of controllers for micro-electromechanical systems (MEMS), labs-on-a-chip or biomimetic soft robots, and the study of microrheology of both gases and soft solids, we analyze the transient fluid--structure interaction (FSIs) between a viscoelastic tube conveying compressible flow at low Reynolds number. We express the density of the fluid as a linear function of the pressure, and we use the lubrication approximation to further simplify the fluid dynamics problem. On the other hand, the structural mechanics is governed by a modified Donnell shell theory accounting for Kelvin--Voigt-type linearly viscoelastic mechanical response. The fluid and structural mechanics problems are coupled through the tubes radial deformation and the hydrodynamic pressure. For small compressibility numbers and weak coupling, the equations are solved analytically via a perturbation expansion. Three illustrative problems are analyzed. First, we obtain exact (but implicit) solutions for the pressure for steady flow conditions. Second, we solve the transient problem of impulsive pressurization of the tubes inlet. Third, we analyze the transient response to an oscillatory inlet pressure. We show that an oscillatory inlet pressure leads to acoustic streaming in the tube, attributed to the nonlinear pressure gradient induced by the interplay of FSI and compressibility. Furthermore, we demonstrate an enhancement in the volumetric flow rate due to FSI coupling. The hydrodynamic pressure oscillations are shown to exhibit a low-pass frequency response (when averaging over the period of oscillations), while the frequency response of the tube deformation is similar to that of a band-pass filter.
Soft hydraulics, which addresses the interaction between an internal flow and a compliant conduit, is a central problem in microfluidics. We analyze Newtonian fluid flow in a rectangular duct with a soft top wall at steady state. The resulting fluid--structure interaction (FSI) is formulated for both vanishing and finite flow inertia. At the leading-order in the small aspect ratio, the lubrication approximation implies that the pressure only varies in the streamwise direction. Meanwhile, the compliant walls slenderness makes the fluid--solid interface behave like a Winkler foundation, with the displacement fully determined by the local pressure. Coupling flow and deformation and averaging across the cross-section leads to a one-dimensional reduced model. In the case of vanishing flow inertia, an effective deformed channel height is defined rigorously to eliminate the spanwise dependence of the deformation. It is shown that a previously-used averaged height concept is an acceptable approximation. From the one-dimensional model, a friction factor and the corresponding Poiseuille number are derived. Unlike the rigid duct case, the Poiseuille number for a compliant duct is not constant but varies in the streamwise direction. Compliance can increase the Poiseuille number by a factor of up to four. The model for finite flow inertia is obtained by assuming a parabolic vertical variation of the streamwise velocity. To satisfy the displacement constraints along the edges of the channel, weak tension is introduced in the streamwise direction to regularize the Winkler-foundation-like model. Matched asymptotic solutions of the regularized model are derived.
Sand traps are used to measure Aeolian flux. Since they modify the surrounding wind velocity field their gauging represents an important challenge. We use numerical simulations under the assumption of homogeneous turbulence based on FLUENT to systematically study the flow field and trapping efficiency of one of the most common devices based on a hollow cylinder with two slits. In particular, we investigate the dependence on the wind speed, the Stokes number, the permeability of the membrane on the slit and the saltation height.
Long, shallow microchannels embedded in thick soft materials are widely used in microfluidic devices for lab-on-a-chip applications. However, the bulging effect caused by fluid--structure interactions between the internal viscous flow and the soft walls has not been completely understood. Previous models either contain a fitting parameter or are specialized to channels with plate-like walls. This work is a theoretical study of the steady-state response of a compliant microchannel with a thick wall. Using lubrication theory for low-Reynolds-number flows and the theory for linearly elastic isotropic solids, we obtain perturbative solutions for the flow and deformation. Specifically, only the channels top wall deformation is considered, and the ratio between its thickness $t$ and width $w$ is assumed to be $(t/w)^2 gg 1$. We show that the deformation at each stream-wise cross-section can be considered independently, and that the top wall can be regarded as a simply supported rectangle subject to uniform pressure at its bottom. The stress and displacement fields are found using Fourier series, based on which the channel shape and the hydrodynamic resistance are calculated, yielding a new flow rate--pressure drop relation without fitting parameters. Our results agree favorably with, and thus rationalize, previous experiments.
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