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Register a new userNuCLS: A scalable crowdsourcing, deep learning approach and dataset for nucleus classification, localization and segmentation
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Added by
Mohamed Amgad
Publication date
2021
fields
Informatics Engineering
and research's language is
English
Authors
Mohamed Amgad
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High-resolution mapping of cells and tissue structures provides a foundation for developing interpretable machine-learning models for computational pathology. Deep learning algorithms can provide accurate mappings given large numbers of labeled instances for training and validation. Generating adequate volume of quality labels has emerged as a critical barrier in computational pathology given the time and effort required from pathologists. In this paper we describe an approach for engaging crowds of medical students and pathologists that was used to produce a dataset of over 220,000 annotations of cell nuclei in breast cancers. We show how suggested annotations generated by a weak algorithm can improve the accuracy of annotations generated by non-experts and can yield useful data for training segmentation algorithms without laborious manual tracing. We systematically examine interrater agreement and describe modifications to the MaskRCNN model to improve cell mapping. We also describe a technique we call Decision Tree Approximation of Learned Embeddings (DTALE) that leverages nucleus segmentations and morphologic features to improve the transparency of nucleus classification models. The annotation data produced in this study are freely available for algorithm development and benchmarking at: https://sites.google.com/view/nucls.
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Using state-of-the-art deep learning models for cancer diagnosis presents several challenges related to the nature and availability of labeled histology images. In particular, cancer grading and localization in these images normally relies on both image- and pixel-level labels, the latter requiring a costly annotation process. In this survey, deep weakly-supervised learning (WSL) models are investigated to identify and locate diseases in histology images, without the need for pixel-level annotations. Given training data with global image-level labels, these models allow to simultaneously classify histology images and yield pixel-wise localization scores, thereby identifying the corresponding regions of interest (ROI). Since relevant WSL models have mainly been investigated within the computer vision community, and validated on natural scene images, we assess the extent to which they apply to histology images which have challenging properties, e.g. very large size, similarity between foreground/background, highly unstructured regions, stain heterogeneity, and noisy/ambiguous labels. The most relevant models for deep WSL are compared experimentally in terms of accuracy (classification and pixel-wise localization) on several public benchmark histology datasets for breast and colon cancer -- BACH ICIAR 2018, BreaKHis, CAMELYON16, and GlaS. Furthermore, for large-scale evaluation of WSL models on histology images, we propose a protocol to construct WSL datasets from Whole Slide Imaging. Results indicate that several deep learning models can provide a high level of classification accuracy, although accurate pixel-wise localization of cancer regions remains an issue for such images. Code is publicly available.
CNN visualization and interpretation methods, like class-activation maps (CAMs), are typically used to highlight the image regions linked to class predictions. These models allow to simultaneously classify images and extract class-dependent saliency maps, without the need for costly pixel-level annotations. However, they typically yield segmentations with high false-positive rates and, therefore, coarse visualisations, more so when processing challenging images, as encountered in histology. To mitigate this issue, we propose an active learning (AL) framework, which progressively integrates pixel-level annotations during training. Given training data with global image-level labels, our deep weakly-supervised learning model jointly performs supervised image-level classification and active learning for segmentation, integrating pixel annotations by an oracle. Unlike standard AL methods that focus on sample selection, we also leverage large numbers of unlabeled images via pseudo-segmentations (i.e., self-learning at the pixel level), and integrate them with the oracle-annotated samples during training. We report extensive experiments over two challenging benchmarks -- high-resolution medical images (histology GlaS data for colon cancer) and natural images (CUB-200-2011 for bird species). Our results indicate that, by simply using random sample selection, the proposed approach can significantly outperform state-of the-art CAMs and AL methods, with an identical oracle-supervision budget. Our code is publicly available.
Recognition of surgical gesture is crucial for surgical skill assessment and efficient surgery training. Prior works on this task are based on either variant graphical models such as HMMs and CRFs, or deep learning models such as Recurrent Neural Networks and Temporal Convolutional Networks. Most of the current approaches usually suffer from over-segmentation and therefore low segment-level edit scores. In contrast, we present an essentially different methodology by modeling the task as a sequential decision-making process. An intelligent agent is trained using reinforcement learning with hierarchical features from a deep model. Temporal consistency is integrated into our action design and reward mechanism to reduce over-segmentation errors. Experiments on JIGSAWS dataset demonstrate that the proposed method performs better than state-of-the-art methods in terms of the edit score and on par in frame-wise accuracy. Our code will be released later.
Plankton are effective indicators of environmental change and ecosystem health in freshwater habitats, but collection of plankton data using manual microscopic methods is extremely labor-intensive and expensive. Automated plankton imaging offers a promising way forward to monitor plankton communities with high frequency and accuracy in real-time. Yet, manual annotation of millions of images proposes a serious challenge to taxonomists. Deep learning classifiers have been successfully applied in various fields and provided encouraging results when used to categorize marine plankton images. Here, we present a set of deep learning models developed for the identification of lake plankton, and study several strategies to obtain optimal performances,which lead to operational prescriptions for users. To this aim, we annotated into 35 classes over 17900 images of zooplankton and large phytoplankton colonies, detected in Lake Greifensee (Switzerland) with the Dual Scripps Plankton Camera. Our best models were based on transfer learning and ensembling, which classified plankton images with 98% accuracy and 93% F1 score. When tested on freely available plankton datasets produced by other automated imaging tools (ZooScan, FlowCytobot and ISIIS), our models performed better than previously used models. Our annotated data, code and classification models are freely available online.
Pavement condition evaluation is essential to time the preventative or rehabilitative actions and control distress propagation. Failing to conduct timely evaluations can lead to severe structural and financial loss of the infrastructure and complete reconstructions. Automated computer-aided surveying measures can provide a database of road damage patterns and their locations. This database can be utilized for timely road repairs to gain the minimum cost of maintenance and the asphalts maximum durability. This paper introduces a deep learning-based surveying scheme to analyze the image-based distress data in real-time. A database consisting of a diverse population of crack distress types such as longitudinal, transverse, and alligator cracks, photographed using mobile-device is used. Then, a family of efficient and scalable models that are tuned for pavement crack detection is trained, and various augmentation policies are explored. Proposed models, resulted in F1-scores, ranging from 52% to 56%, and average inference time from 178-10 images per second. Finally, the performance of the object detectors are examined, and error analysis is reported against various images. The source code is available at https://github.com/mahdi65/roadDamageDetection2020.
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