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Deep Active Learning for Joint Classification & Segmentation with Weak Annotator

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 Added by Soufiane Belharbi
 Publication date 2020
and research's language is English




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CNN visualization and interpretation methods, like class-activation maps (CAMs), are typically used to highlight the image regions linked to class predictions. These models allow to simultaneously classify images and extract class-dependent saliency maps, without the need for costly pixel-level annotations. However, they typically yield segmentations with high false-positive rates and, therefore, coarse visualisations, more so when processing challenging images, as encountered in histology. To mitigate this issue, we propose an active learning (AL) framework, which progressively integrates pixel-level annotations during training. Given training data with global image-level labels, our deep weakly-supervised learning model jointly performs supervised image-level classification and active learning for segmentation, integrating pixel annotations by an oracle. Unlike standard AL methods that focus on sample selection, we also leverage large numbers of unlabeled images via pseudo-segmentations (i.e., self-learning at the pixel level), and integrate them with the oracle-annotated samples during training. We report extensive experiments over two challenging benchmarks -- high-resolution medical images (histology GlaS data for colon cancer) and natural images (CUB-200-2011 for bird species). Our results indicate that, by simply using random sample selection, the proposed approach can significantly outperform state-of the-art CAMs and AL methods, with an identical oracle-supervision budget. Our code is publicly available.



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Semantic segmentation is a crucial task in biomedical image processing, which recent breakthroughs in deep learning have allowed to improve. However, deep learning methods in general are not yet widely used in practice since they require large amount of data for training complex models. This is particularly challenging for biomedical images, because data and ground truths are a scarce resource. Annotation efforts for biomedical images come with a real cost, since experts have to manually label images at pixel-level on samples usually containing many instances of the target anatomy (e.g. in histology samples: neurons, astrocytes, mitochondria, etc.). In this paper we provide a framework for Deep Active Learning applied to a real-world scenario. Our framework relies on the U-Net architecture and overall uncertainty measure to suggest which sample to annotate. It takes advantage of the uncertainty measure obtained by taking Monte Carlo samples while using Dropout regularization scheme. Experiments were done on spinal cord and brain microscopic histology samples to perform a myelin segmentation task. Two realistic small datasets of 14 and 24 images were used, from different acquisition settings (Serial Block-Face Electron Microscopy and Transmitting Electron Microscopy) and showed that our method reached a maximum Dice value after adding 3 uncertainty-selected samples to the initial training set, versus 15 randomly-selected samples, thereby significantly reducing the annotation effort. We focused on a plausible scenario and showed evidence that this straightforward implementation achieves a high segmentation performance with very few labelled samples. We believe our framework may benefit any biomedical researcher willing to obtain fast and accurate image segmentation on their own dataset. The code is freely available at https://github.com/neuropoly/deep-active-learning.
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We propose ViewAL, a novel active learning strategy for semantic segmentation that exploits viewpoint consistency in multi-view datasets. Our core idea is that inconsistencies in model predictions across viewpoints provide a very reliable measure of uncertainty and encourage the model to perform well irrespective of the viewpoint under which objects are observed. To incorporate this uncertainty measure, we introduce a new viewpoint entropy formulation, which is the basis of our active learning strategy. In addition, we propose uncertainty computations on a superpixel level, which exploits inherently localized signal in the segmentation task, directly lowering the annotation costs. This combination of viewpoint entropy and the use of superpixels allows to efficiently select samples that are highly informative for improving the network. We demonstrate that our proposed active learning strategy not only yields the best-performing models for the same amount of required labeled data, but also significantly reduces labeling effort. For instance, our method achieves 95% of maximum achievable network performance using only 7%, 17%, and 24% labeled data on SceneNet-RGBD, ScanNet, and Matterport3D, respectively. On these datasets, the best state-of-the-art method achieves the same performance with 14%, 27% and 33% labeled data. Finally, we demonstrate that labeling using superpixels yields the same quality of ground-truth compared to labeling whole images, but requires 25% less time.
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