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Register a new userReal-time full-field imaging through scattering media by all-optical feedback
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Full-field imaging through scattering media is fraught with many challenges. Despite many achievements in recent years, current imaging methods are too slow to deal with fast dynamics that occur for example in biomedical imaging. Here we present an ultra-fast all-optical method, where the object to be imaged and the scattering medium (diffuser) are inserted into a highly multimode self-imaging laser cavity. We show that the intra-cavity laser light from the object is mainly focused onto specific regions of the scattering medium where the phase variations are low. Thus, round trip loss within the laser cavity is minimized, thereby overcoming most of the scattering effects. The method is exploited to image objects through scattering media whose diffusion angle is lower than the numerical aperture of the laser cavity. As our method is based on optical feedback inside a laser cavity, it can deal with temporal variations that occur on timescales as short as several cavity round trips, with an upper bound of 200 ns.
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Super-resolution imaging with advanced optical systems has been revolutionizing technical analysis in various fields from biological to physical sciences. However, many objects are hidden by strongly scattering media such as rough wall corners or biological tissues that scramble light paths, create speckle patterns and hinder objects visualization, let alone super-resolution imaging. Here, we realize a method to do non-invasive super-resolution imaging through scattering media based on stochastic optical scattering localization imaging (SOSLI) technique. Simply by capturing multiple speckle patterns of photo-switchable emitters in our demonstration, the stochastic approach utilizes the speckle correlation properties of scattering media to retrieve an image with more than five-fold resolution enhancement compared to the diffraction limit, while posing no fundamental limit in achieving higher spatial resolution. More importantly, we demonstrate our SOSLI to do non-invasive super-resolution imaging through not only optical diffusers, i.e. static scattering media, but also biological tissues, i.e. dynamic scattering media with decorrelation of up to 80%. Our approach paves the way to non-invasively visualize various samples behind scattering media at unprecedented levels of detail.
Extending super-resolution imaging techniques to objects hidden in strongly scattering media potentially revolutionize the technical analysis for much broader categories of samples, such as biological tissues. The main challenge is the medias inhomogeneous structures which scramble the light path and create noise-like speckle patterns, hindering the objects visualization even at a low-resolution level. Here, we propose a computational method relying on the objects spatial and temporal fluctuation to visualize nanoscale objects through scattering media non-invasively. The fluctuating object can be achieved by random speckle illumination, illuminating through dynamic scattering media, or flickering emitters. The optical memory effect allows us to derive the object at diffraction limit resolution and estimate the point spreading function (PSF). Multiple images of the fluctuating object are obtained by deconvolution, then super-resolution images are achieved by computing the high order cumulants. Non-linearity of high order cumulant significantly suppresses the noise and artifacts in the resulting images and enhances the resolution by a factor of $sqrt{N}$, where $N$ is the cumulant order. Our non-invasive super-resolution speckle fluctuation imaging (NISFFI) presents a nanoscopy technique with very simple hardware to visualize samples behind scattering media.
Ghost imaging with thermal light in scattering media is investigated. We demonstrated both theoretically and experimentally for the first time that the image with high quality can still be obtained in the scattering media by ghost imaging. The scattering effect on the qualities of the images obtained when the object is illuminated directly by the thermal light and ghost imaging is analyzed theoretically. Its potential applications are also discussed.
We present a novel diffractive imaging method that harnesses a low-resolution real-space image to guide the phase retrieval. A computational algorithm is developed to utilize such prior knowledge as a real-space constraint in the iterative phase retrieval procedure. Numerical simulations and proof-of-concept experiments are carried out, demonstrating our methods capability of reconstructing high-resolution details that are otherwise inaccessible with traditional phasing algorithms. With the present method, we formulate a conceptual design for the coherent imaging experiments at a next-generation X-ray light source.
Optical focusing through/inside scattering media, like multimode fiber and biological tissues, has significant impact in biomedicine yet considered challenging due to strong scattering nature of light. Previously, promising progress has been made, benefiting from the iterative optical wavefront shaping, with which deep-tissue high-resolution optical focusing becomes possible. Most of iterative algorithms can overcome noise perturbations but fail to effectively adapt beyond the noise, e.g. sudden strong perturbations. Re-optimizations are usually needed for significant decorrelated medium since these algorithms heavily rely on the optimization in the previous iterations. Such ineffectiveness is probably due to the absence of a metric that can gauge the deviation of the instant wavefront from the optimum compensation based on the concurrently measured optical focusing. In this study, a square rule of binary-amplitude modulation, directly relating the measured focusing performance with the error in the optimized wavefront, is theoretically proved and experimentally validated. With this simple rule, it is feasible to quantify how many pixels on the spatial light modulator incorrectly modulate the wavefront for the instant status of the medium or the whole system. As an example of application, we propose a novel algorithm, dynamic mutation algorithm, with high adaptability against perturbations by probing how far the optimization has gone toward the theoretically optimum. The diminished focus of scattered light can be effectively recovered when perturbations to the medium cause significant drop of the focusing performance, which no existing algorithms can achieve due to their inherent strong dependence on previous optimizations. With further improvement, this study may boost or inspire many applications, like high-resolution imaging and stimulation, in instable scattering environments.
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