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We present an evaluation of the effectiveness of manual contact tracing compared to bulletin board contact tracing. We show that bulletin board contact tracing gives comparable results in terms of the reproductive number, duration, prevalence and incidence but is less resource intensive, easier to implement and offers a wider range of privacy options. Classical contact tracing focuses on contacting individuals whom an infectious person has been in proximity to. A bulletin board approach focuses on identifying locations visited by an infectious person, and then contacting those who were at those locations. We present results comparing their effects on the overall reproductive number as well as the incidence and prevalence of disease. We evaluate them by building a new discrete time stochastic model based on the Susceptible Exposed Infectious and Recovered (SEIR) framework for disease spread. We conduct simulation experiments to quantify the effectiveness of these two models of contact tracing by calibrating the model to be compatible with SARS-CoV-2. Our experiments show that location-based bulletin board contact tracing can improve manual contact tracing.
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The COVID-19 infection cases have surged globally, causing devastations to both the society and economy. A key factor contributing to the sustained spreading is the presence of a large number of asymptomatic or hidden spreaders, who mix among the susceptible population without being detected or quarantined. Here we propose an effective non-pharmacological intervention method of detecting the asymptomatic spreaders in contact-tracing networks, and validated it on the empirical COVID-19 spreading network in Singapore. We find that using pure physical spreading equations, the hidden spreaders of COVID-19 can be identified with remarkable accuracy. Specifically, based on the unique characteristics of COVID-19 spreading dynamics, we propose a computational framework capturing the transition probabilities among different infectious states in a network, and extend it to an efficient algorithm to identify asymptotic individuals. Our simulation results indicate that a screening method using our prediction outperforms machine learning algorithms, e.g. graph neural networks, that are designed as baselines in this work, as well as random screening of infections closest contacts widely used by China in its early outbreak. Furthermore, our method provides high precision even with incomplete information of the contract-tracing networks. Our work can be of critical importance to the non-pharmacological interventions of COVID-19, especially with increasing adoptions of contact tracing measures using various new technologies. Beyond COVID-19, our framework can be useful for other epidemic diseases that also feature asymptomatic spreading
Mumbai, amongst the most densely populated cities in the world, has witnessed the fourth largest number of cases and the largest number of deaths among all the cities in India (as of 28th October 2020). Along with the rest of India, lockdowns (of varying degrees) have been in effect in Mumbai since March 25, 2020. Given the large economic toll on the country from the lockdown and the related restrictions on mobility of people and goods, swift opening of the economy especially in a financial hub such as Mumbai becomes critical. In this report, we use the IISc-TIFR agent based simulator to develop long term projections for Mumbai under realistic scenarios related to Mumbais opening of the workplaces, or equivalently, the economy, and the associated public transportation through local trains and buses. These projections were developed taking into account a possible second wave if the economy and the local trains are fully opened either on November 1, 2020 or on January 1, 2021. The impact on infection spread in Mumbai if the schools and colleges open on January first week 2021 is also considered. We also try to account for the increased intermingling amongst the population during the Ganeshotsav festival as well as around the Navratri/Dussehra and Diwali festival. Our conclusion, based on our simulations, is that the impact of fully opening up the economy on November 1 is manageable provided reasonable medical infrastructure is in place. Further, schools and colleges opening in January do not lead to excessive increase in infections. The report also explores the relative effectiveness of contact tracing vs containment zones, and also includes very rudimentary results of the effect of vaccinating the elderly population in February 2021.
The pandemic of COVID-19 has caused severe public health consequences around the world. Many interventions of COVID-19 have been implemented. It is of great public health and societal importance to evaluate the effects of interventions in the pandemic of COVID-19. In this paper, with help of synthetic control method, regression discontinuity and a Susceptible-Infected and infectious without isolation-Hospitalized in isolation-Removed (SIHR) model, we evaluate the horizontal and longitudinal effects of stringent interventions implemented in Wenzhou, a representative urban city of China, where stringent interventions were enforced to curb its own epidemic situation with rapidly increasing newly confirmed cases. We found that there were statistically significant treatment effects of those stringent interventions which reduced the cumulative confirmed cases of COVID-19. Those reduction effects would increase over time. Also, if the stringent interventions were delayed by 2 days or mild interventions were implemented instead, the expected number of cumulative confirmed cases would have been nearly 2 times or 5 times of the actual number. The effects of stringent interventions are significant in mitigating the epidemic situation of COVID-19. The slower the interventions were implemented, the more severe the epidemic would have been, and the stronger the interventions would have been required.
The modeling of the spreading of communicable diseases has experienced significant advances in the last two decades or so. This has been possible due to the proliferation of data and the development of new methods to gather, mine and analyze it. A key role has also been played by the latest advances in new disciplines like network science. Nonetheless, current models still lack a faithful representation of all possible heterogeneities and features that can be extracted from data. Here, we bridge a current gap in the mathematical modeling of infectious diseases and develop a framework that allows to account simultaneously for both the connectivity of individuals and the age-structure of the population. We compare different scenarios, namely, i) the homogeneous mixing setting, ii) one in which only the social mixing is taken into account, iii) a setting that considers the connectivity of individuals alone, and finally, iv) a multilayer representation in which both the social mixing and the number of contacts are included in the model. We analytically show that the thresholds obtained for these four scenarios are different. In addition, we conduct extensive numerical simulations and conclude that heterogeneities in the contact network are important for a proper determination of the epidemic threshold, whereas the age-structure plays a bigger role beyond the onset of the outbreak. Altogether, when it comes to evaluate interventions such as vaccination, both sources of individual heterogeneity are important and should be concurrently considered. Our results also provide an indication of the errors incurred in situations in which one cannot access all needed information in terms of connectivity and age of the population.
We study the epidemic spreading on spatial networks where the probability that two nodes are connected decays with their distance as a power law. As the exponent of the distance dependence grows, model networks smoothly transition from the random network limit to the regular lattice limit. We show that despite keeping the average number of contacts constant, the increasing exponent hampers the epidemic spreading by making long-distance connections less frequent. The spreading dynamics is influenced by the distance-dependence exponent as well and changes from exponential growth to power-law growth. The observed power-law growth is compatible with recent analyses of empirical data on the spreading of COVID-19 in numerous countries.
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