Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userMeta Ordinal Regression Forest For Learning with Unsure Lung Nodules
224
0
0.0
(
0
)
Added by
Yiming Lei
Publication date
2020
fields
Informatics Engineering
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
Deep learning-based methods have achieved promising performance in early detection and classification of lung nodules, most of which discard unsure nodules and simply deal with a binary classification -- malignant vs benign. Recently, an unsure data model (UDM) was proposed to incorporate those unsure nodules by formulating this problem as an ordinal regression, showing better performance over traditional binary classification. To further explore the ordinal relationship for lung nodule classification, this paper proposes a meta ordinal regression forest (MORF), which improves upon the state-of-the-art ordinal regression method, deep ordinal regression forest (DORF), in three major ways. First, MORF can alleviate the biases of the predictions by making full use of deep features while DORF needs to fix the composition of decision trees before training. Second, MORF has a novel grouped feature selection (GFS) module to re-sample the split nodes of decision trees. Last, combined with GFS, MORF is equipped with a meta learning-based weighting scheme to map the features selected by GFS to tree-wise weights while DORF assigns equal weights for all trees. Experimental results on the LIDC-IDRI dataset demonstrate superior performance over existing methods, including the state-of-the-art DORF.
rate research
Read More
Image ordinal estimation is to predict the ordinal label of a given image, which can be categorized as an ordinal regression problem. Recent methods formulate an ordinal regression problem as a series of binary classification problems. Such methods cannot ensure that the global ordinal relationship is preserved since the relationships among different binary classifiers are neglected. We propose a novel ordinal regression approach, termed Convolutional Ordinal Regression Forest or CORF, for image ordinal estimation, which can integrate ordinal regression and differentiable decision trees with a convolutional neural network for obtaining precise and stable global ordinal relationships. The advantages of the proposed CORF are twofold. First, instead of learning a series of binary classifiers emph{independently}, the proposed method aims at learning an ordinal distribution for ordinal regression by optimizing those binary classifiers emph{simultaneously}. Second, the differentiable decision trees in the proposed CORF can be trained together with the ordinal distribution in an end-to-end manner. The effectiveness of the proposed CORF is verified on two image ordinal estimation tasks, i.e. facial age estimation and image aesthetic assessment, showing significant improvements and better stability over the state-of-the-art ordinal regression methods.
The progression of lung cancer implies the intrinsic ordinal relationship of lung nodules at different stages-from benign to unsure then to malignant. This problem can be solved by ordinal regression methods, which is between classification and regression due to its ordinal label. However, existing convolutional neural network (CNN)-based ordinal regression methods only focus on modifying classification head based on a randomly sampled mini-batch of data, ignoring the ordinal relationship resided in the data itself. In this paper, we propose a Meta Ordinal Weighting Network (MOW-Net) to explicitly align each training sample with a meta ordinal set (MOS) containing a few samples from all classes. During the training process, the MOW-Net learns a mapping from samples in MOS to the corresponding class-specific weight. In addition, we further propose a meta cross-entropy (MCE) loss to optimize the network in a meta-learning scheme. The experimental results demonstrate that the MOW-Net achieves better accuracy than the state-of-the-art ordinal regression methods, especially for the unsure class.
Uncertainty is the only certainty there is. Modeling data uncertainty is essential for regression, especially in unconstrained settings. Traditionally the direct regression formulation is considered and the uncertainty is modeled by modifying the output space to a certain family of probabilistic distributions. On the other hand, classification based regression and ranking based solutions are more popular in practice while the direct regression methods suffer from the limited performance. How to model the uncertainty within the present-day technologies for regression remains an open issue. In this paper, we propose to learn probabilistic ordinal embeddings which represent each data as a multivariate Gaussian distribution rather than a deterministic point in the latent space. An ordinal distribution constraint is proposed to exploit the ordinal nature of regression. Our probabilistic ordinal embeddings can be integrated into popular regression approaches and empower them with the ability of uncertainty estimation. Experimental results show that our approach achieves competitive performance. Code is available at https://github.com/Li-Wanhua/POEs.
Early detection of lung cancer has been proven to decrease mortality significantly. A recent development in computed tomography (CT), spectral CT, can potentially improve diagnostic accuracy, as it yields more information per scan than regular CT. However, the shear workload involved with analyzing a large number of scans drives the need for automated diagnosis methods. Therefore, we propose a detection and classification system for lung nodules in CT scans. Furthermore, we want to observe whether spectral images can increase classifier performance. For the detection of nodules we trained a VGG-like 3D convolutional neural net (CNN). To obtain a primary tumor classifier for our dataset we pre-trained a 3D CNN with similar architecture on nodule malignancies of a large publicly available dataset, the LIDC-IDRI dataset. Subsequently we used this pre-trained network as feature extractor for the nodules in our dataset. The resulting feature vectors were classified into two (benign/malignant) and three (benign/primary lung cancer/metastases) classes using support vector machine (SVM). This classification was performed both on nodule- and scan-level. We obtained state-of-the art performance for detection and malignancy regression on the LIDC-IDRI database. Classification performance on our own dataset was higher for scan- than for nodule-level predictions. For the three-class scan-level classification we obtained an accuracy of 78%. Spectral features did increase classifier performance, but not significantly. Our work suggests that a pre-trained feature extractor can be used as primary tumor origin classifier for lung nodules, eliminating the need for elaborate fine-tuning of a new network and large datasets. Code is available at url{https://github.com/tueimage/lung-nodule-msc-2018}.
Follow-up serves an important role in the management of pulmonary nodules for lung cancer. Imaging diagnostic guidelines with expert consensus have been made to help radiologists make clinical decision for each patient. However, tumor growth is such a complicated process that it is difficult to stratify high-risk nodules from low-risk ones based on morphologic characteristics. On the other hand, recent deep learning studies using convolutional neural networks (CNNs) to predict the malignancy score of nodules, only provides clinicians with black-box predictions. To this end, we propose a unified framework, named Nodule Follow-Up Prediction Network (NoFoNet), which predicts the growth of pulmonary nodules with high-quality visual appearances and accurate quantitative results, given any time interval from baseline observations. It is achieved by predicting future displacement field of each voxel with a WarpNet. A TextureNet is further developed to refine textural details of WarpNet outputs. We also introduce techniques including Temporal Encoding Module and Warp Segmentation Loss to encourage time-aware and shape-aware representation learning. We build an in-house follow-up dataset from two medical centers to validate the effectiveness of the proposed method. NoFoNet significantly outperforms direct prediction by a U-Net in terms of visual quality; more importantly, it demonstrates accurate differentiating performance between high- and low-risk nodules. Our promising results suggest the potentials in computer aided intervention for lung nodule management.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
