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Register a new userIdentification of Ischemic Heart Disease by using machine learning technique based on parameters measuring Heart Rate Variability
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The diagnosis of heart diseases is a difficult task generally addressed by an appropriate examination of patients clinical data. Recently, the use of heart rate variability (HRV) analysis as well as of some machine learning algorithms, has proved to be a valuable support in the diagnosis process. However, till now, ischemic heart disease (IHD) has been diagnosed on the basis of Artificial Neural Networks (ANN) applied only to signs, symptoms and sequential ECG and coronary angiography, an invasive tool, while could be probably identified in a non-invasive way by using parameters extracted from HRV, a signal easily obtained from the ECG. In this study, 18 non-invasive features (age, gender, left ventricular ejection fraction and 15 obtained from HRV) of 243 subjects (156 normal subjects and 87 IHD patients) were used to train and validate a series of several ANN, different for number of input and hidden nodes. The best result was obtained using 7 input parameters and 7 hidden nodes with an accuracy of 98.9% and 82% for the training and validation dataset, respectively.
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Ischemic heart disease (IHD), particularly in its chronic stable form, is a subtle pathology due to its silent behavior before developing in unstable angina, myocardial infarction or sudden cardiac death. Machine learning techniques applied to parameters extracted form heart rate variability (HRV) signal seem to be a valuable support in the early diagnosis of some cardiac diseases. However, so far, IHD patients were identified using Artificial Neural Networks (ANNs) applied to a limited number of HRV parameters and only to very few subjects. In this study, we used several linear and non-linear HRV parameters applied to ANNs, in order to confirm these results on a large cohort of 965 sample of subjects and to identify which features could discriminate IHD patients with high accuracy. By using principal component analysis and stepwise regression, we reduced the original 17 parameters to five, used as inputs, for a series of ANNs. The highest accuracy of 82% was achieved using meanRR, LFn, SD1, gender and age parameters and two hidden neurons.
Diagnosing pre-existing heart diseases early in life is important as it helps prevent complications such as pulmonary hypertension, heart rhythm problems, blood clots, heart failure and sudden cardiac arrest. To identify such diseases, phonocardiogram (PCG) and electrocardiogram (ECG) waveforms convey important information. Therefore, effectively using these two modalities of data has the potential to improve the disease screening process. We evaluate this hypothesis on a subset of the PhysioNet Challenge 2016 Dataset which contains simultaneously acquired PCG and ECG recordings. Our novel Dual-Convolutional Neural Network based approach uses transfer learning to tackle the problem of having limited amounts of simultaneous PCG and ECG data that is publicly available, while having the potential to adapt to larger datasets. In addition, we introduce two main evaluation frameworks named record-wise and sample-wise evaluation which leads to a rich performance evaluation for the transfer learning approach. Comparisons with methods which used single or dual modality data show that our method can lead to better performance. Furthermore, our results show that individually collected ECG or PCG waveforms are able to provide transferable features which could effectively help to make use of a limited number of synchronized PCG and ECG waveforms and still achieve significant classification performance.
This study investigates the potential of deep learning methods to identify individuals with suspected COVID-19 infection using remotely collected heart-rate data. The study utilises data from the ongoing EU IMI RADAR-CNS research project that is investigating the feasibility of wearable devices and smart phones to monitor individuals with multiple sclerosis (MS), depression or epilepsy. Aspart of the project protocol, heart-rate data was collected from participants using a Fitbit wristband. The presence of COVID-19 in the cohort in this work was either confirmed through a positive swab test, or inferred through the self-reporting of a combination of symptoms including fever, respiratory symptoms, loss of smell or taste, tiredness and gastrointestinal symptoms. Experimental results indicate that our proposed contrastive convolutional auto-encoder (contrastive CAE), i. e., a combined architecture of an auto-encoder and contrastive loss, outperforms a conventional convolutional neural network (CNN), as well as a convolutional auto-encoder (CAE) without using contrastive loss. Our final contrastive CAE achieves 95.3% unweighted average recall, 86.4% precision, anF1 measure of 88.2%, a sensitivity of 100% and a specificity of 90.6% on a testset of 19 participants with MS who reported symptoms of COVID-19. Each of these participants was paired with a participant with MS with no COVID-19 symptoms.
This paper presents a robust method to monitor heart rate (HR) from BCG (Ballistocardiography) signal, which is acquired from the sensor embedded in a chair or a mattress. The proposed algorithm addresses the shortfalls in traditional Fast Fourier Transform (FFT) based approaches by introducing Hilbert Transform to extract the pulse envelope that models the repetition of J-peaks in BCG signal. The frequency resolution is further enhanced by applying FFT and phase vocoder to the pulse envelope. The performance of the proposed algorithm is verified by experiment from 7 subjects. For HR estimation, mean absolute error (MAE) of 0.90 beats per minute (BPM) and standard deviation of absolute error (STD) of 1.14 BPM are obtained. Pearson correlation coefficient between estimated HR and ground truth HR of 0.98 is also achieved.
This paper proposes a novel framework for the segmentation of phonocardiogram (PCG) signals into heart states, exploiting the temporal evolution of the PCG as well as considering the salient information that it provides for the detection of the heart state. We propose the use of recurrent neural networks and exploit recent advancements in attention based learning to segment the PCG signal. This allows the network to identify the most salient aspects of the signal and disregard uninformative information. The proposed method attains state-of-the-art performance on multiple benchmarks including both human and animal heart recordings. Furthermore, we empirically analyse different feature combinations including envelop features, wavelet and Mel Frequency Cepstral Coefficients (MFCC), and provide quantitative measurements that explore the importance of different features in the proposed approach. We demonstrate that a recurrent neural network coupled with attention mechanisms can effectively learn from irregular and noisy PCG recordings. Our analysis of different feature combinations shows that MFCC features and their derivatives offer the best performance compared to classical wavelet and envelop features. Heart sound segmentation is a crucial pre-processing step for many diagnostic applications. The proposed method provides a cost effective alternative to labour extensive manual segmentation, and provides a more accurate segmentation than existing methods. As such, it can improve the performance of further analysis including the detection of murmurs and ejection clicks. The proposed method is also applicable for detection and segmentation of other one dimensional biomedical signals.
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