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In our experience of working with domain experts who are using todays AutoML systems, a common problem we encountered is what we call unrealistic expectations -- when users are facing a very challenging task with noisy data acquisition process, whilst being expected to achieve startlingly high accuracy with machine learning (ML). Consequently, many computationally expensive AutoML runs and labour-intensive ML development processes are predestined to fail from the beginning. In traditional software engineering, this problem is addressed via a feasibility study, an indispensable step before developing any software system. In this paper, we present ease.ml/snoopy with the goal of preforming an automatic feasibility study before building ML applications or collecting too many samples. A user provides inputs in the form of a dataset, which is representative for the task and data acquisition process, and a quality target (e.g., expected accuracy > 0.8). The system returns its deduction on whether this target is achievable using ML given the input data. We approach this problem by estimating the irreducible error of the underlying task, also known as Bayes error. The technical key contribution of this work is the design of a practical Bayes error estimator. We carefully evaluate the benefits and limitations of running ease.ml/snoopy prior to training ML models on too noisy datasets for reaching the desired target accuracy. By including the automatic feasibility study into the iterative label cleaning process, users are able to save substantial labeling time and monetary efforts.
Continuous integration is an indispensable step of modern software engineering practices to systematically manage the life cycles of system development. Developing a machine learning model is no difference - it is an engineering process with a life cycle, including design, implementation, tuning, testing, and deployment. However, most, if not all, existing continuous integration engines do not support machine learning as first-class citizens. In this paper, we present ease.ml/ci, to our best knowledge, the first continuous integration system for machine learning. The challenge of building ease.ml/ci is to provide rigorous guarantees, e.g., single accuracy point error tolerance with 0.999 reliability, with a practical amount of labeling effort, e.g., 2K labels per test. We design a domain specific language that allows users to specify integration conditions with reliability constraints, and develop simple novel optimizations that can lower the number of labels required by up to two orders of magnitude for test conditions popularly used in real production systems.
Recent years have witnessed an explosive growth of mobile devices. Mobile devices are permeating every aspect of our daily lives. With the increasing usage of mobile devices and intelligent applications, there is a soaring demand for mobile applications with machine learning services. Inspired by the tremendous success achieved by deep learning in many machine learning tasks, it becomes a natural trend to push deep learning towards mobile applications. However, there exist many challenges to realize deep learning in mobile applications, including the contradiction between the miniature nature of mobile devices and the resource requirement of deep neural networks, the privacy and security concerns about individuals data, and so on. To resolve these challenges, during the past few years, great leaps have been made in this area. In this paper, we provide an overview of the current challenges and representative achievements about pushing deep learning on mobile devices from three aspects: training with mobile data, efficient inference on mobile devices, and applications of mobile deep learning. The former two aspects cover the primary tasks of deep learning. Then, we go through our two recent applications that apply the data collected by mobile devices to inferring mood disturbance and user identification. Finally, we conclude this paper with the discussion of the future of this area.
Almost all neural architecture search methods are evaluated in terms of performance (i.e. test accuracy) of the model structures that it finds. Should it be the only metric for a good autoML approach? To examine aspects beyond performance, we propose a set of criteria aimed at evaluating the core of autoML problem: the amount of human intervention required to deploy these methods into real world scenarios. Based on our proposed evaluation checklist, we study the effectiveness of a random search strategy for fully automated multimodal neural architecture search. Compared to traditional methods that rely on manually crafted feature extractors, our method selects each modality from a large search space with minimal human supervision. We show that our proposed random search strategy performs close to the state of the art on the AV-MNIST dataset while meeting the desirable characteristics for a fully automated design process.
Thanks to the increasing availability of genomics and other biomedical data, many machine learning approaches have been proposed for a wide range of therapeutic discovery and development tasks. In this survey, we review the literature on machine learning applications for genomics through the lens of therapeutic development. We investigate the interplay among genomics, compounds, proteins, electronic health records (EHR), cellular images, and clinical texts. We identify twenty-two machine learning in genomics applications across the entire therapeutics pipeline, from discovering novel targets, personalized medicine, developing gene-editing tools all the way to clinical trials and post-market studies. We also pinpoint seven important challenges in this field with opportunities for expansion and impact. This survey overviews recent research at the intersection of machine learning, genomics, and therapeutic development.
Machine Learning (ML) is proving extremely beneficial in many healthcare applications. In pediatric oncology, retrospective studies that investigate the relationship between treatment and late adverse effects still rely on simple heuristics. To assess the effects of radiation therapy, treatment plans are typically simulated on phantoms, i.e., virtual surrogates of patient anatomy. Currently, phantoms are built according to reasonable, yet simple, human-designed criteria. This often results in a lack of individualization. We present a novel approach that combines imaging and ML to build individualized phantoms automatically. Given the features of a patient treated historically (only 2D radiographs available), and a database of 3D Computed Tomography (CT) imaging with organ segmentations and relative patient features, our approach uses ML to predict how to assemble a patient-specific phantom automatically. Experiments on 60 abdominal CTs of pediatric patients show that our approach constructs significantly more representative phantoms than using current phantom building criteria, in terms of location and shape of the abdomen and of two considered organs, the liver and the spleen. Among several ML algorithms considered, the Gene-pool Optimal Mixing Evolutionary Algorithm for Genetic Programming (GP-GOMEA) is found to deliver the best performing models, which are, moreover, transparent and interpretable mathematical expressions.