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Register a new userA Macro-Micro Weakly-supervised Framework for AS-OCT Tissue Segmentation
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Munan Ning
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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Primary angle closure glaucoma (PACG) is the leading cause of irreversible blindness among Asian people. Early detection of PACG is essential, so as to provide timely treatment and minimize the vision loss. In the clinical practice, PACG is diagnosed by analyzing the angle between the cornea and iris with anterior segment optical coherence tomography (AS-OCT). The rapid development of deep learning technologies provides the feasibility of building a computer-aided system for the fast and accurate segmentation of cornea and iris tissues. However, the application of deep learning methods in the medical imaging field is still restricted by the lack of enough fully-annotated samples. In this paper, we propose a novel framework to segment the target tissues accurately for the AS-OCT images, by using the combination of weakly-annotated images (majority) and fully-annotated images (minority). The proposed framework consists of two models which provide reliable guidance for each other. In addition, uncertainty guided strategies are adopted to increase the accuracy and stability of the guidance. Detailed experiments on the publicly available AGE dataset demonstrate that the proposed framework outperforms the state-of-the-art semi-/weakly-supervised methods and has a comparable performance as the fully-supervised method. Therefore, the proposed method is demonstrated to be effective in exploiting information contained in the weakly-annotated images and has the capability to substantively relieve the annotation workload.
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Recently, significant improvement has been made on semantic object segmentation due to the development of deep convolutional neural networks (DCNNs). Training such a DCNN usually relies on a large number of images with pixel-level segmentation masks, and annotating these images is very costly in terms of both finance and human effort. In this paper, we propose a simple to complex (STC) framework in which only image-level annotations are utilized to learn DCNNs for semantic segmentation. Specifically, we first train an initial segmentation network called Initial-DCNN with the saliency maps of simple images (i.e., those with a single category of major object(s) and clean background). These saliency maps can be automatically obtained by existing bottom-up salient object detection techniques, where no supervision information is needed. Then, a better network called Enhanced-DCNN is learned with supervision from the predicted segmentation masks of simple images based on the Initial-DCNN as well as the image-level annotations. Finally, more pixel-level segmentation masks of complex images (two or more categories of objects with cluttered background), which are inferred by using Enhanced-DCNN and image-level annotations, are utilized as the supervision information to learn the Powerful-DCNN for semantic segmentation. Our method utilizes $40$K simple images from Flickr.com and 10K complex images from PASCAL VOC for step-wisely boosting the segmentation network. Extensive experimental results on PASCAL VOC 2012 segmentation benchmark well demonstrate the superiority of the proposed STC framework compared with other state-of-the-arts.
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Acquisition of training data for the standard semantic segmentation is expensive if requiring that each pixel is labeled. Yet, current methods significantly deteriorate in weakly supervised settings, e.g. where a fraction of pixels is labeled or when only image-level tags are available. It has been shown that regularized losses - originally developed for unsupervised low-level segmentation and representing geometric priors on pixel labels - can considerably improve the quality of weakly supervised training. However, many common priors require optimization stronger than gradient descent. Thus, such regularizers have limited applicability in deep learning. We propose a new robust trust region approach for regularized losses improving the state-of-the-art results. Our approach can be seen as a higher-order generalization of the classic chain rule. It allows neural network optimization to use strong low-level solvers for the corresponding regularizers, including discrete ones.
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