No Arabic abstract
Developing spatio-temporal crime prediction models, and to a lesser extent, developing measures of accuracy and operational efficiency for them, has been an active area of research for almost two decades. Despite calls for rigorous and independent evaluations of model performance, such studies have been few and far between. In this paper, we argue that studies should focus not on finding the one predictive model or the one measure that is the most appropriate at all times, but instead on careful consideration of several factors that affect the choice of the model and the choice of the measure, to find the best measure and the best model for the problem at hand. We argue that because each problem is unique, it is important to develop measures that empower the practitioner with the ability to input the choices and preferences that are most appropriate for the problem at hand. We develop a new measure called the penalized predictive accuracy index (PPAI) which imparts such flexibility. We also propose the use of the expected utility function to combine multiple measures in a way that is appropriate for a given problem in order to assess the models against multiple criteria. We further propose the use of the average logarithmic score (ALS) measure that is appropriate for many crime models and measures accuracy differently than existing measures. These measures can be used alongside existing measures to provide a more comprehensive means of assessing the accuracy and potential utility of spatio-temporal crime prediction models.
Just-in-time adaptive interventions (JITAIs) are time-varying adaptive interventions that use frequent opportunities for the intervention to be adapted--weekly, daily, or even many times a day. The micro-randomized trial (MRT) has emerged for use in informing the construction of JITAIs. MRTs can be used to address research questions about whether and under what circumstances JITAI components are effective, with the ultimate objective of developing effective and efficient JITAI. The purpose of this article is to clarify why, when, and how to use MRTs; to highlight elements that must be considered when designing and implementing an MRT; and to review primary and secondary analyses methods for MRTs. We briefly review key elements of JITAIs and discuss a variety of considerations that go into planning and designing an MRT. We provide a definition of causal excursion effects suitable for use in primary and secondary analyses of MRT data to inform JITAI development. We review the weighted and centered least-squares (WCLS) estimator which provides consistent causal excursion effect estimators from MRT data. We describe how the WCLS estimator along with associated test statistics can be obtained using standard statistical software such as R (R Core Team, 2019). Throughout we illustrate the MRT design and analyses using the HeartSteps MRT, for developing a JITAI to increase physical activity among sedentary individuals. We supplement the HeartSteps MRT with two other MRTs, SARA and BariFit, each of which highlights different research questions that can be addressed using the MRT and experimental design considerations that might arise.
Many researchers have hypothesised models which explain the evolution of the topology of a target network. The framework described in this paper gives the likelihood that the target network arose from the hypothesised model. This allows rival hypothesised models to be compared for their ability to explain the target network. A null model (of random evolution) is proposed as a baseline for comparison. The framework also considers models made from linear combinations of model components. A method is given for the automatic optimisation of component weights. The framework is tested on simulated networks with known parameters and also on real data.
Crime prediction plays an impactful role in enhancing public security and sustainable development of urban. With recent advances in data collection and integration technologies, a large amount of urban data with rich crime-related information and fine-grained spatio-temporal logs has been recorded. Such helpful information can boost our understandings about the temporal evolution and spatial factors of urban crimes and can enhance accurate crime prediction. In this paper, we perform crime prediction exploiting the cross-type and spatio-temporal correlations of urban crimes. In particular, we verify the existence of correlations among different types of crime from temporal and spatial perspectives, and propose a coherent framework to mathematically model these correlations for crime prediction. The extensive experimental results on real-world data validate the effectiveness of the proposed framework. Further experiments have been conducted to understand the importance of different correlations in crime prediction.
Finding translational biomarkers stands center stage of the future of personalized medicine in healthcare. We observed notable challenges in identifying robust biomarkers as some with great performance in one scenario often fail to perform well in new trials (e.g. different population, indications). With rapid development in the clinical trial world (e.g. assay, disease definition), new trials very likely differ from legacy ones in many perspectives and in development of biomarkers this heterogeneity should be considered. In response, we recommend considering building in the heterogeneity when evaluating biomarkers. In this paper, we present one evaluation strategy by using leave-one-study-out (LOSO) in place of conventional cross-validation (cv) methods to account for the potential heterogeneity across trials used for building and testing the biomarkers. To demonstrate the performance of K-fold vs LOSO cv in estimating the effect size of biomarkers, we leveraged data from clinical trials and simulation studies. In our assessment, LOSO cv provided a more objective estimate of the future performance. This conclusion remained true across different evaluation metrics and different statistical methods.
Evidence for Action (E4A), a signature program of the Robert Wood Johnson Foundation, funds investigator-initiated research on the impacts of social programs and policies on population health and health inequities. Across thousands of letters of intent and full proposals E4A has received since 2015, one of the most common methodological challenges faced by applicants is selecting realistic effect sizes to inform power and sample size calculations. E4A prioritizes health studies that are both (1) adequately powered to detect effect sizes that may reasonably be expected for the given intervention and (2) likely to achieve intervention effects sizes that, if demonstrated, correspond to actionable evidence for population health stakeholders. However, little guidance exists to inform the selection of effect sizes for population health research proposals. We draw on examples of five rigorously evaluated population health interventions. These examples illustrate considerations for selecting realistic and actionable effect sizes as inputs to power and sample size calculations for research proposals to study population health interventions. We show that plausible effects sizes for population health inteventions may be smaller than commonly cited guidelines suggest. Effect sizes achieved with population health interventions depend on the characteristics of the intervention, the target population, and the outcomes studied. Population health impact depends on the proportion of the population receiving the intervention. When adequately powered, even studies of interventions with small effect sizes can offer valuable evidence to inform population health if such interventions can be implemented broadly. Demonstrating the effectiveness of such interventions, however, requires large sample sizes.