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Register a new userODVICE: An Ontology-Driven Visual Analytic Tool for Interactive Cohort Extraction
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Added by
Mohamed Ghalwash
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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Increased availability of electronic health records (EHR) has enabled researchers to study various medical questions. Cohort selection for the hypothesis under investigation is one of the main consideration for EHR analysis. For uncommon diseases, cohorts extracted from EHRs contain very limited number of records - hampering the robustness of any analysis. Data augmentation methods have been successfully applied in other domains to address this issue mainly using simulated records. In this paper, we present ODVICE, a data augmentation framework that leverages the medical concept ontology to systematically augment records using a novel ontologically guided Monte-Carlo graph spanning algorithm. The tool allows end users to specify a small set of interactive controls to control the augmentation process. We analyze the importance of ODVICE by conducting studies on MIMIC-III dataset for two learning tasks. Our results demonstrate the predictive performance of ODVICE augmented cohorts, showing ~30% improvement in area under the curve (AUC) over the non-augmented dataset and other data augmentation strategies.
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Despite the large number of patients in Electronic Health Records (EHRs), the subset of usable data for modeling outcomes of specific phenotypes are often imbalanced and of modest size. This can be attributed to the uneven coverage of medical concepts in EHRs. In this paper, we propose OMTL, an Ontology-driven Multi-Task Learning framework, that is designed to overcome such data limitations. The key contribution of our work is the effective use of knowledge from a predefined well-established medical relationship graph (ontology) to construct a novel deep learning network architecture that mirrors this ontology. It can effectively leverage knowledge from a well-established medical relationship graph (ontology) by constructing a deep learning network architecture that mirrors this graph. This enables common representations to be shared across related phenotypes, and was found to improve the learning performance. The proposed OMTL naturally allows for multitask learning of different phenotypes on distinct predictive tasks. These phenotypes are tied together by their semantic distance according to the external medical ontology. Using the publicly available MIMIC-III database, we evaluate OMTL and demonstrate its efficacy on several real patient outcome predictions over state-of-the-art multi-task learning schemes.
Understanding procedural text requires tracking entities, actions and effects as the narrative unfolds. We focus on the challenging real-world problem of action-graph extraction from material science papers, where language is highly specialized and data annotation is expensive and scarce. We propose a novel approach, Text2Quest, where procedural text is interpreted as instructions for an interactive game. A learning agent completes the game by executing the procedure correctly in a text-based simulated lab environment. The framework can complement existing approaches and enables richer forms of learning compared to static texts. We discuss potential limitations and advantages of the approach, and release a prototype proof-of-concept, hoping to encourage research in this direction.
Biomedical researchers use ontologies to annotate their data with ontology terms, enabling better data integration and interoperability. However, the number, variety and complexity of current biomedical ontologies make it cumbersome for researchers to determine which ones to reuse for their specific needs. To overcome this problem, in 2010 the National Center for Biomedical Ontology (NCBO) released the Ontology Recommender, which is a service that receives a biomedical text corpus or a list of keywords and suggests ontologies appropriate for referencing the indicated terms. We developed a new version of the NCBO Ontology Recommender. Called Ontology Recommender 2.0, it uses a new recommendation approach that evaluates the relevance of an ontology to biomedical text data according to four criteria: (1) the extent to which the ontology covers the input data; (2) the acceptance of the ontology in the biomedical community; (3) the level of detail of the ontology classes that cover the input data; and (4) the specialization of the ontology to the domain of the input data. Our evaluation shows that the enhanced recommender provides higher quality suggestions than the original approach, providing better coverage of the input data, more detailed information about their concepts, increased specialization for the domain of the input data, and greater acceptance and use in the community. In addition, it provides users with more explanatory information, along with suggestions of not only individual ontologies but also groups of ontologies. It also can be customized to fit the needs of different scenarios. Ontology Recommender 2.0 combines the strengths of its predecessor with a range of adjustments and new features that improve its reliability and usefulness. Ontology Recommender 2.0 recommends over 500 biomedical ontologies from the NCBO BioPortal platform, where it is openly available.
We present a suite of IDL routines to interactively run GALFIT whereby the various surface brightness profiles (and their associated parameters) are represented by regions, which the User is expected to place. The regions may be saved and/or loaded from the ASCII format used by ds9 or in the Hierarchical Data Format (version 5). The software has been tested to run stably on Mac OS X and Linux with IDL 7.0.4. In addition to its primary purpose of modeling galaxy images with GALFIT, this package has several ancillary uses, including a flexible image display routines, several basic photometry functions, and qualitatively assessing Source Extractor. We distribute the package freely and without any implicit or explicit warranties, guarantees, or assurance of any kind. We kindly ask users to report any bugs, errors, or suggestions to us directly (as opposed to fixing them themselves) to ensure version control and uniformity.
Intersectional bias is a bias caused by an overlap of multiple social factors like gender, sexuality, race, disability, religion, etc. A recent study has shown that word embedding models can be laden with biases against intersectional groups like African American females, etc. The first step towards tackling such intersectional biases is to identify them. However, discovering biases against different intersectional groups remains a challenging task. In this work, we present WordBias, an interactive visual tool designed to explore biases against intersectional groups encoded in static word embeddings. Given a pretrained static word embedding, WordBias computes the association of each word along different groups based on race, age, etc. and then visualizes them using a novel interactive interface. Using a case study, we demonstrate how WordBias can help uncover biases against intersectional groups like Black Muslim Males, Poor Females, etc. encoded in word embedding. In addition, we also evaluate our tool using qualitative feedback from expert interviews. The source code for this tool can be publicly accessed for reproducibility at github.com/bhavyaghai/WordBias.
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