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Register a new userAn Inductive Transfer Learning Approach using Cycle-consistent Adversarial Domain Adaptation with Application to Brain Tumor Segmentation
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With recent advances in supervised machine learning for medical image analysis applications, the annotated medical image datasets of various domains are being shared extensively. Given that the annotation labelling requires medical expertise, such labels should be applied to as many learning tasks as possible. However, the multi-modal nature of each annotated image renders it difficult to share the annotation label among diverse tasks. In this work, we provide an inductive transfer learning (ITL) approach to adopt the annotation label of the source domain datasets to tasks of the target domain datasets using Cycle-GAN based unsupervised domain adaptation (UDA). To evaluate the applicability of the ITL approach, we adopted the brain tissue annotation label on the source domain dataset of Magnetic Resonance Imaging (MRI) images to the task of brain tumor segmentation on the target domain dataset of MRI. The results confirm that the segmentation accuracy of brain tumor segmentation improved significantly. The proposed ITL approach can make significant contribution to the field of medical image analysis, as we develop a fundamental tool to improve and promote various tasks using medical images.
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Recently deep learning has been playing a major role in the field of computer vision. One of its applications is the reduction of human judgment in the diagnosis of diseases. Especially, brain tumor diagnosis requires high accuracy, where minute errors in judgment may lead to disaster. For this reason, brain tumor segmentation is an important challenge for medical purposes. Currently several methods exist for tumor segmentation but they all lack high accuracy. Here we present a solution for brain tumor segmenting by using deep learning. In this work, we studied different angles of brain MR images and applied different networks for segmentation. The effect of using separate networks for segmentation of MR images is evaluated by comparing the results with a single network. Experimental evaluations of the networks show that Dice score of 0.73 is achieved for a single network and 0.79 in obtained for multiple networks.
We focus on Unsupervised Domain Adaptation (UDA) for the task of semantic segmentation. Recently, adversarial alignment has been widely adopted to match the marginal distribution of feature representations across two domains globally. However, this strategy fails in adapting the representations of the tail classes or small objects for semantic segmentation since the alignment objective is dominated by head categories or large objects. In contrast to adversarial alignment, we propose to explicitly train a domain-invariant classifier by generating and defensing against pointwise feature space adversarial perturbations. Specifically, we firstly perturb the intermediate feature maps with several attack objectives (i.e., discriminator and classifier) on each individual position for both domains, and then the classifier is trained to be invariant to the perturbations. By perturbing each position individually, our model treats each location evenly regardless of the category or object size and thus circumvents the aforementioned issue. Moreover, the domain gap in feature space is reduced by extrapolating source and target perturbed features towards each other with attack on the domain discriminator. Our approach achieves the state-of-the-art performance on two challenging domain adaptation tasks for semantic segmentation: GTA5 -> Cityscapes and SYNTHIA -> Cityscapes.
In medical applications, the same anatomical structures may be observed in multiple modalities despite the different image characteristics. Currently, most deep models for multimodal segmentation rely on paired registered images. However, multimodal paired registered images are difficult to obtain in many cases. Therefore, developing a model that can segment the target objects from different modalities with unpaired images is significant for many clinical applications. In this work, we propose a novel two-stream translation and segmentation unified attentional generative adversarial network (UAGAN), which can perform any-to-any image modality translation and segment the target objects simultaneously in the case where two or more modalities are available. The translation stream is used to capture modality-invariant features of the target anatomical structures. In addition, to focus on segmentation-related features, we add attentional blocks to extract valuable features from the translation stream. Experiments on three-modality brain tumor segmentation indicate that UAGAN outperforms the existing methods in most cases.
Retinal vessel segmentation plays a key role in computer-aided screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Recently, deep learning-based retinal vessel segmentation algorithms have achieved remarkable performance. However, due to the domain shift problem, the performance of these algorithms often degrades when they are applied to new data that is different from the training data. Manually labeling new data for each test domain is often a time-consuming and laborious task. In this work, we explore unsupervised domain adaptation in retinal vessel segmentation by using entropy-based adversarial learning and transfer normalization layer to train a segmentation network, which generalizes well across domains and requires no annotation of the target domain. Specifically, first, an entropy-based adversarial learning strategy is developed to reduce the distribution discrepancy between the source and target domains while also achieving the objective of entropy minimization on the target domain. In addition, a new transfer normalization layer is proposed to further boost the transferability of the deep network. It normalizes the features of each domain separately to compensate for the domain distribution gap. Besides, it also adaptively selects those feature channels that are more transferable between domains, thus further enhancing the generalization performance of the network. We conducted extensive experiments on three regular fundus image datasets and an ultra-widefield fundus image dataset, and the results show that our approach yields significant performance gains compared to other state-of-the-art methods.
Domain adaptation is one of the most crucial techniques to mitigate the domain shift problem, which exists when transferring knowledge from an abundant labeled sourced domain to a target domain with few or no labels. Partial domain adaptation addresses the scenario when target categories are only a subset of source categories. In this paper, to enable the efficient representation of cross-domain plant images, we first extract deep features from pre-trained models and then develop adversarial consistent learning ($ACL$) in a unified deep architecture for partial domain adaptation. It consists of source domain classification loss, adversarial learning loss, and feature consistency loss. Adversarial learning loss can maintain domain-invariant features between the source and target domains. Moreover, feature consistency loss can preserve the fine-grained feature transition between two domains. We also find the shared categories of two domains via down-weighting the irrelevant categories in the source domain. Experimental results demonstrate that training features from NASNetLarge model with proposed $ACL$ architecture yields promising results on the PlantCLEF 2020 Challenge.
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