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Register a new userUnified Attentional Generative Adversarial Network for Brain Tumor Segmentation From Multimodal Unpaired Images
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In medical applications, the same anatomical structures may be observed in multiple modalities despite the different image characteristics. Currently, most deep models for multimodal segmentation rely on paired registered images. However, multimodal paired registered images are difficult to obtain in many cases. Therefore, developing a model that can segment the target objects from different modalities with unpaired images is significant for many clinical applications. In this work, we propose a novel two-stream translation and segmentation unified attentional generative adversarial network (UAGAN), which can perform any-to-any image modality translation and segment the target objects simultaneously in the case where two or more modalities are available. The translation stream is used to capture modality-invariant features of the target anatomical structures. In addition, to focus on segmentation-related features, we add attentional blocks to extract valuable features from the translation stream. Experiments on three-modality brain tumor segmentation indicate that UAGAN outperforms the existing methods in most cases.
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Recently deep learning has been playing a major role in the field of computer vision. One of its applications is the reduction of human judgment in the diagnosis of diseases. Especially, brain tumor diagnosis requires high accuracy, where minute errors in judgment may lead to disaster. For this reason, brain tumor segmentation is an important challenge for medical purposes. Currently several methods exist for tumor segmentation but they all lack high accuracy. Here we present a solution for brain tumor segmenting by using deep learning. In this work, we studied different angles of brain MR images and applied different networks for segmentation. The effect of using separate networks for segmentation of MR images is evaluated by comparing the results with a single network. Experimental evaluations of the networks show that Dice score of 0.73 is achieved for a single network and 0.79 in obtained for multiple networks.
The diagnosis and segmentation of tumors using any medical diagnostic tool can be challenging due to the varying nature of this pathology. Magnetic Reso- nance Imaging (MRI) is an established diagnostic tool for various diseases and disorders and plays a major role in clinical neuro-diagnosis. Supplementing this technique with automated classification and segmentation tools is gaining importance, to reduce errors and time needed to make a conclusive diagnosis. In this paper a simple three-step algorithm is proposed; (1) identification of patients that present with tumors, (2) automatic selection of abnormal slices of the patients, and (3) segmentation and detection of the tumor. Features were extracted by using discrete wavelet transform on the normalized images and classified by support vector machine (for step (1)) and random forest (for step (2)). The 400 subjects were divided in a 3:1 ratio between training and test with no overlap. This study is novel in terms of use of data, as it employed the entire T2 weighted slices as a single image for classification and a unique combination of contralateral approach with patch thresholding for segmentation, which does not require a training set or a template as is used by most segmentation studies. Using the proposed method, the tumors were segmented accurately with a classification accuracy of 95% with 100% specificity and 90% sensitivity.
In this paper, we propose a novel learning based method for automated segmenta-tion of brain tumor in multimodal MRI images. The machine learned features from fully convolutional neural network (FCN) and hand-designed texton fea-tures are used to classify the MRI image voxels. The score map with pixel-wise predictions is used as a feature map which is learned from multimodal MRI train-ing dataset using the FCN. The learned features are then applied to random for-ests to classify each MRI image voxel into normal brain tissues and different parts of tumor. The method was evaluated on BRATS 2013 challenge dataset. The results show that the application of the random forest classifier to multimodal MRI images using machine-learned features based on FCN and hand-designed features based on textons provides promising segmentations. The Dice overlap measure for automatic brain tumor segmentation against ground truth is 0.88, 080 and 0.73 for complete tumor, core and enhancing tumor, respectively.
With recent advances in supervised machine learning for medical image analysis applications, the annotated medical image datasets of various domains are being shared extensively. Given that the annotation labelling requires medical expertise, such labels should be applied to as many learning tasks as possible. However, the multi-modal nature of each annotated image renders it difficult to share the annotation label among diverse tasks. In this work, we provide an inductive transfer learning (ITL) approach to adopt the annotation label of the source domain datasets to tasks of the target domain datasets using Cycle-GAN based unsupervised domain adaptation (UDA). To evaluate the applicability of the ITL approach, we adopted the brain tissue annotation label on the source domain dataset of Magnetic Resonance Imaging (MRI) images to the task of brain tumor segmentation on the target domain dataset of MRI. The results confirm that the segmentation accuracy of brain tumor segmentation improved significantly. The proposed ITL approach can make significant contribution to the field of medical image analysis, as we develop a fundamental tool to improve and promote various tasks using medical images.
Accurate segmentation of brain tumors from magnetic resonance imaging (MRI) is clinically relevant in diagnoses, prognoses and surgery treatment, which requires multiple modalities to provide complementary morphological and physiopathologic information. However, missing modality commonly occurs due to image corruption, artifacts, different acquisition protocols or allergies to certain contrast agents in clinical practice. Though existing efforts demonstrate the possibility of a unified model for all missing situations, most of them perform poorly when more than one modality is missing. In this paper, we propose a novel Adversarial Co-training Network (ACN) to solve this issue, in which a series of independent yet related models are trained dedicated to each missing situation with significantly better results. Specifically, ACN adopts a novel co-training network, which enables a coupled learning process for both full modality and missing modality to supplement each others domain and feature representations, and more importantly, to recover the `missing information of absent modalities. Then, two unsupervised modules, i.e., entropy and knowledge adversarial learning modules are proposed to minimize the domain gap while enhancing prediction reliability and encouraging the alignment of latent representations, respectively. We also adapt modality-mutual information knowledge transfer learning to ACN to retain the rich mutual information among modalities. Extensive experiments on BraTS2018 dataset show that our proposed method significantly outperforms all state-of-the-art methods under any missing situation.
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