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Register a new userEstimating Fiber Orientation Distribution through Blockwise Adaptive Thresholding with Application to HCP Young Adults Data
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Due to recent technological advances, large brain imaging data sets can now be collected. Such data are highly complex so extraction of meaningful information from them remains challenging. Thus, there is an urgent need for statistical procedures that are computationally scalable and can provide accurate estimates that capture the neuronal structures and their functionalities. We propose a fast method for estimating the fiber orientation distribution(FOD) based on diffusion MRI data. This method models the observed dMRI signal at any voxel as a convolved and noisy version of the underlying FOD, and utilizes the spherical harmonics basis for representing the FOD, where the spherical harmonic coefficients are adaptively and nonlinearly shrunk by using a James-Stein type estimator. To further improve the estimation accuracy by enhancing the localized peaks of the FOD, as a second step a super-resolution sharpening process is then applied. The resulting estimated FODs can be fed to a fiber tracking algorithm to reconstruct the white matter fiber tracts. We illustrate the overall methodology using both synthetic data and data from the Human Connectome Project.
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We present a novel method for estimation of the fiber orientation distribution (FOD) function based on diffusion-weighted Magnetic Resonance Imaging (D-MRI) data. We formulate the problem of FOD estimation as a regression problem through spherical deconvolution and a sparse representation of the FOD by a spherical needlets basis that form a multi-resolution tight frame for spherical functions. This sparse representation allows us to estimate FOD by an $l_1$-penalized regression under a non-negativity constraint. The resulting convex optimization problem is solved by an alternating direction method of multipliers (ADMM) algorithm. The proposed method leads to a reconstruction of the FODs that is accurate, has low variability and preserves sharp features. Through extensive experiments, we demonstrate the effectiveness and favorable performance of the proposed method compared with two existing methods. Particularly, we show the ability of the proposed method in successfully resolving fiber crossing at small angles and in automatically identifying isotropic diffusion. We also apply the proposed method to real 3T D-MRI data sets of healthy elderly individuals. The results show realistic descriptions of crossing fibers that are more accurate and less noisy than competing methods even with a relatively small number of gradient directions.
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In this paper the TileShuffle method is evaluated as a search method for candidate lncRNAs at 8q24.2. The method is run on three microarrays. Microarrays which all contained the same sample and repeated copies of tiled probes. This allows the coherence of the selection method within and between microarrays to be estimated by Monte Carlo simulations on the repeated probes.
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