Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userEstimating robustness of the tileShuffle method with repeated probes
141
0
0.0
(
0
)
Ask ChatGPT about the research
No Arabic abstract
In this paper the TileShuffle method is evaluated as a search method for candidate lncRNAs at 8q24.2. The method is run on three microarrays. Microarrays which all contained the same sample and repeated copies of tiled probes. This allows the coherence of the selection method within and between microarrays to be estimated by Monte Carlo simulations on the repeated probes.
rate research
Read More
We have developed a statistical method named IsoDOT to assess differential isoform expression (DIE) and differential isoform usage (DIU) using RNA-seq data. Here isoform usage refers to relative isoform expression given the total expression of the corresponding gene. IsoDOT performs two tasks that cannot be accomplished by existing methods: to test DIE/DIU with respect to a continuous covariate, and to test DIE/DIU for one case versus one control. The latter task is not an uncommon situation in practice, e.g., comparing paternal and maternal allele of one individual or comparing tumor and normal sample of one cancer patient. Simulation studies demonstrate the high sensitivity and specificity of IsoDOT. We apply IsoDOT to study the effects of haloperidol treatment on mouse transcriptome and identify a group of genes whose isoform usages respond to haloperidol treatment.
An econometric analysis of consumer research data which hit newspaper headlines in the Netherlands illustrates almost everything that can go wrong when statistical models are fit to the superficial characteristics of a data-set with no attention paid to the data generation mechanism. This paper is dedicated to Ornulf Borgan on the occasion of his virtual 65th birthday celebrations.
This study aimed at estimating total forest above-ground net change (Delta AGB, Mt) over five years (2014-2019) based on model-assisted estimation utilizing freely available satellite imagery. The study was conducted for a boreal forest area (approx. 1.4 Mill hectares) in Norway where bi-temporal national forest inventory (NFI), Sentinel-2, and Landsat data were available. Biomass change was modelled based on a direct approach. The precision of estimates using only the NFI data in a basic expansion estimator were compared to four different alternative model-assisted estimates using 1) Sentinel-2 or Landsat data, and 2) using bi- or uni-temporal remotely sensed data. We found that the use of remotely sensed data improved the precision of the purely field-based estimates by a factor of up to three. The most precise estimates were found for the model-assisted estimation using bi-temporal Sentinel-2 (standard error; SE= 1.7 Mt). However, the decrease in precision when using Landsat data was small (SE= 1.92 Mt). In addition, we found that Delta AGB could be precisely estimated also when remotely sensed data were available only at the end of the monitoring period. We conclude that satellite optical data can considerably improve Delta AGB estimates, even in those cases where repeated and coincident NFI data are available. The free availability, global coverage, frequent update, and long-term time horizon make data from programs such as Sentinel-2 and Landsat a valuable data source for a consistent and durable monitoring of forest carbon dynamics.
The aim of this study was to evaluate the performance of a classical method of fractal analysis, Detrended Fluctuation Analysis (DFA), in the analysis of the dynamics of animal behavior time series. In order to correctly use DFA to assess the presence of long-range correlation, previous authors using statistical model systems have stated that different aspects should be taken into account such as: 1) the establishment by hypothesis testing of the absence of short term correlation, 2) an accurate estimation of a straight line in the log-log plot of the fluctuation function, 3) the elimination of artificial crossovers in the fluctuation function, and 4) the length of the time series. Taking into consideration these factors, herein we evaluated the presence of long-range correlation in the temporal pattern of locomotor activity of Japanese quail ({sl Coturnix coturnix}) and mosquito larva ({sl Culex quinquefasciatus}). In our study, modeling the data with the general ARFIMA model, we rejected the hypothesis of short range correlations (d=0) in all cases. We also observed that DFA was able to distinguish between the artificial crossover observed in the temporal pattern of locomotion of Japanese quail, and the crossovers in the correlation behavior observed in mosquito larvae locomotion. Although the test duration can slightly influence the parameter estimation, no qualitative differences were observed between different test durations.
Due to recent technological advances, large brain imaging data sets can now be collected. Such data are highly complex so extraction of meaningful information from them remains challenging. Thus, there is an urgent need for statistical procedures that are computationally scalable and can provide accurate estimates that capture the neuronal structures and their functionalities. We propose a fast method for estimating the fiber orientation distribution(FOD) based on diffusion MRI data. This method models the observed dMRI signal at any voxel as a convolved and noisy version of the underlying FOD, and utilizes the spherical harmonics basis for representing the FOD, where the spherical harmonic coefficients are adaptively and nonlinearly shrunk by using a James-Stein type estimator. To further improve the estimation accuracy by enhancing the localized peaks of the FOD, as a second step a super-resolution sharpening process is then applied. The resulting estimated FODs can be fed to a fiber tracking algorithm to reconstruct the white matter fiber tracts. We illustrate the overall methodology using both synthetic data and data from the Human Connectome Project.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
