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Minimal cost-time strategies for population replacement using the IIT

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 Added by Yannick Privat
 Publication date 2020
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and research's language is English




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Vector control plays a central role in the fight against vector-borne diseases and, in particular, arboviruses. The use of the endosymbiotic bacterium Wolbachia has proven effective in preventing the transmission of some of these viruses between mosquitoes and humans, making it a promising control tool. The Incompatible Insect Technique (IIT) consists in replacing the wild population by a population carrying the aforementioned bacterium, thereby preventing outbreaks of the associated vector-borne diseases. In this work, we consider a two species model incorporating both Wolbachia infected and wild mosquitoes. Our system can be controlled thanks to a term representing an artificial introduction of Wolbachia-infected mosquitoes. Under the assumption that the birth rate of mosquitoes is high, we may reduce the model to a simpler one on the proportion of infected mosquitoes. We investigate minimal cost-time strategies to achieve a population replacement both analytically and numerically for the simplified 1D model and only numerically for the full 2D system



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In this article, we are interested in the analysis and simulation of solutions to an optimal control problem motivated by population dynamics issues. In order to control the spread of mosquito-borne arboviruses, the population replacement technique consists in releasing into the environment mosquitoes infected with the Wolbachia bacterium, which greatly reduces the transmission of the virus to the humans. Spatial releases are then sought in such a way that the infected mosquito population invades the uninfected mosquito population. Assuming very high mosquito fecundity rates, we first introduce an asymptotic model on the proportion of infected mosquitoes and then an optimal control problem to determine the best spatial strategy to achieve these releases. We then analyze this problem, including the optimality of natural candidates and carry out first numerical simulations in one dimension of space to illustrate the relevance of our approach.
159 - Cyril Letrouit 2020
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