No Arabic abstract
We revisit well-established concepts of epidemiology, the Ising-model, and percolation theory. Also, we employ a spin $S$ = 1/2 Ising-like model and a (logistic) Fermi-Dirac-like function to describe the spread of Covid-19. Our analysis reinforces well-established literature results, namely: emph{i}) that the epidemic curves can be described by a Gaussian-type function; emph{ii}) that the temporal evolution of the accumulative number of infections and fatalities follow a logistic function, which has some resemblance with a distorted Fermi-Dirac-like function; emph{iii}) the key role played by the quarantine to block the spread of Covid-19 in terms of an emph{interacting} parameter, which emulates the contact between infected and non-infected people. Furthermore, in the frame of elementary percolation theory, we show that: emph{i}) the percolation probability can be associated with the probability of a person being infected with Covid-19; emph{ii}) the concepts of blocked and non-blocked connections can be associated, respectively, with a person respecting or not the social distancing, impacting thus in the probability of an infected person to infect other people. Increasing the number of infected people leads to an increase in the number of net connections, giving rise thus to a higher probability of new infections (percolation). We demonstrate the importance of social distancing in preventing the spread of Covid-19 in a pedagogical way. Given the impossibility of making a precise forecast of the disease spread, we highlight the importance of taking into account additional factors, such as climate changes and urbanization, in the mathematical description of epidemics. Yet, we make a connection between the standard mathematical models employed in epidemics and well-established concepts in condensed matter Physics, such as the Fermi gas and the Landau Fermi-liquid picture.
We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population, can be solved exactly, even in the presence of a time-dependent infection rate. This delay model has a higher degree of accuracy than that of the so-called SIR model, commonly used in epidemiology, which, instead, is formulated in terms of ordinary differential equations. We apply this model to describe the outbreak of the new infectious disease, Covid-19, in Italy, taking into account the containment measures implemented by the government in order to mitigate the spreading of the virus and the social costs for the population.
We proposed a Monte-Carlo method to estimate temporal reproduction number without complete information about symptom onsets of all cases. Province-level analysis demonstrated the huge success of Chinese control measures on COVID-19, that is, provinces reproduction numbers quickly decrease to <1 by just one week after taking actions.
Within a short period of time, COVID-19 grew into a world-wide pandemic. Transmission by pre-symptomatic and asymptomatic viral carriers rendered intervention and containment of the disease extremely challenging. Based on reported infection case studies, we construct an epidemiological model that focuses on transmission around the symptom onset. The model is calibrated against incubation period and pairwise transmission statistics during the initial outbreaks of the pandemic outside Wuhan with minimal non-pharmaceutical interventions. Mathematical treatment of the model yields explicit expressions for the size of latent and pre-symptomatic subpopulations during the exponential growth phase, with the local epidemic growth rate as input. We then explore reduction of the basic reproduction number R_0 through specific disease control measures such as contact tracing, testing, social distancing, wearing masks and sheltering in place. When these measures are implemented in combination, their effects on R_0 multiply. We also compare our model behaviour to the first wave of the COVID-19 spreading in various affected regions and highlight generic and less generic features of the pandemic development.
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic threatens the health of humans and causes great economic losses. Predictive modelling and forecasting the epidemic trends are essential for developing countermeasures to mitigate this pandemic. We develop a network model, where each node represents an individual and the edges represent contacts between individuals where the infection can spread. The individuals are classified based on the number of contacts they have each day (their node degrees) and their infection status. The transmission network model was respectively fitted to the reported data for the COVID-19 epidemic in Wuhan (China), Toronto (Canada), and the Italian Republic using a Markov Chain Monte Carlo (MCMC) optimization algorithm. Our model fits all three regions well with narrow confidence intervals and could be adapted to simulate other megacities or regions. The model projections on the role of containment strategies can help inform public health authorities to plan control measures.
One of the key indicators used in tracking the evolution of an infectious disease isthe reproduction number. This quantity is usually computed using the reportednumber of cases, but ignoring that many more individuals may be infected (e.g.asymptomatics). We propose a statistical procedure to quantify the impact of un-detected infectious cases on the determination of the effective reproduction number. Our approach is stochastic, data-driven and not relying on any compartmentalmodel. It is applied to the COVID-19 case in eight different countries and all Italianregions, showing that the effect of undetected cases leads to estimates of the effective reproduction numbers larger than those obtained only with the reported cases by factors ranging from two to ten. Our findings urge caution about deciding when and how to relax containment measures based on the value of the reproduction number.