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Register a new userDevelopment of a high-resolution and high efficiency Single Photon detector for studying cardiovascular diseases in mice
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SPECT systems using pinhole apertures permit radiolabeled molecular distributions to be imaged in vivo in small animals. Nevertheless studying cardiovascular diseases by means of small animal models is very challenging. Specifically, submillimeter spatial resolution, good energy resolution and high sensitivity are required. We designed what we consider the optimal radionuclide detector system for this task. It should allow studying both detection of unstable atherosclerotic plaques and monitoring the effect of therapies. Using mice is particularly challenging in situations that require several intravenous injections of radiotracers, possibly for week or even months, in chronically ill animals. Thus, alternative routes of delivering the radiotracer in tail vein should be investigated. In this study we have performed preliminary measurements of detection of atherosclerotic plaques in genetically modified mice with high-resolution prototype detector. We have also evaluated the feasibility of assessing left ventricular perfusion by intraperitoneal delivering of MIBI-Tc in healthy mice.
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We discuss a novel approach to the problem of creating a photon number resolving detector using the giant Kerr nonlinearities available in electromagnetically induced transparency. Our scheme can implement a photon number quantum non-demolition measurement with high efficiency ($sim$99%) using less than 1600 atoms embedded in a dielectric waveguide.
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