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The adaptive Wynn-algorithm in generalized linear models with univariate response

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 Added by Fritjof Freise
 Publication date 2019
and research's language is English




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For a nonlinear regression model the information matrices of designs depend on the parameter of the model. The adaptive Wynn-algorithm for D-optimal design estimates the parameter at each step on the basis of the employed design points and observed responses so far, and selects the next design point as in the classical Wynn-algorithm for D-optimal design. The name `Wynn-algorithm is in honor of Henry P. Wynn who established the latter `classical algorithm in his 1970 paper. The asymptotics of the sequences of designs and maximum likelihood estimates generated by the adaptive algorithm is studied for an important class of nonlinear regression models: generalized linear models whose (univariate) response variables follow a distribution from a one-parameter exponential family. Under the assumptions of compactness of the experimental region and of the parameter space together with some natural continuity assumptions it is shown that the adaptive ML-estimators are strongly consistent and the design sequence is asymptotically locally D-optimal at the true parameter point. If the true parameter point is an interior point of the parameter space then under some smoothness assumptions the asymptotic normality of the adaptive ML-estimators is obtained.



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The paper continues the authors work on the adaptive Wynn algorithm in a nonlinear regression model. In the present paper it is shown that if the mean response function satisfies a condition of `saturated identifiability, which was introduced by Pronzato cite{Pronzato}, then the adaptive least squares estimators are strongly consistent. The condition states that the regression parameter is identifiable under any saturated design, i.e., the values of the mean response function at any $p$ distinct design points determine the parameter point uniquely where, typically, $p$ is the dimension of the regression parameter vector. Further essential assumptions are compactness of the experimental region and of the parameter space together with some natural continuity assumptions. If the true parameter point is an interior point of the parameter space then under some smoothness assumptions and asymptotic homoscedasticity of random errors the asymptotic normality of adaptive least squares estimators is obtained.
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