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Register a new userA highly accurate determination of absorbed power during nanomagnetic hyperthermia
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Absorbed power of nanoparticles during magnetic hyperthermia can be well determined from changes in the quality factor ($Q$ factor) of a resonator, in which the radiofrequency (RF) absorbent is placed. We present an order of magnitude improvement in the $Q$ factor measurement accuracy over conventional methods by studying the switch-on and off transient signals of the resonators. A nuclear magnetic resonance (NMR) console is ideally suited to acquire the transient signals and it also allows to employ the so-called pulse phase-cycling to remove transient artifacts. The improved determination of the absorbed power is demonstrated on various resonators in the 1-30 MHz range including standard solenoids and also a birdcage resonator. This leads to the possibility to detect minute amounts of ferrite nanoparticles which are embedded in the body and also the amount of the absorbed power. We demonstrate this capability on a phantom study, where the exact location of an embedded ferrite is clearly detected.
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Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measurement. We present the validation for two types of resonators with very different filling factors: a solenoid and a so-called birdcage coil. The latter is a volume coil, which is generally used in magnetic resonance imaging (MRI) under in vivo condition. The presented method therefore allows to effectively combine MRI and thermotherapy and is thus readily adaptable to existing imaging hardware.
The microwave cavity perturbation method is often used to determine material parameters (electric permittivity and magnetic permeability) at high frequencies and it relies on measurement of the resonator parameters. We present a method to determine the $Q$-factor and resonance frequency of microwave resonators which is conceptually simple but provides a sensitivity for these parameters which overcomes those of existing methods by an order of magnitude. The microwave resonator is placed in a feedback resonator setup, where the output of an amplifier is connected to its own input with the resonator as a band pass filter. After reaching steady-state oscillation, the feedback circuit is disrupted by a fast microwave switch and the transient signal, which emanates from the resonator, is detected using down-conversion. The Fourier transform of the resulting time-dependent signal yields directly the resonance profile of the resonator. Albeit the method is highly accurate, this comes with a conceptual simplicity, ease of implementation and lower circuit cost. We compare existing methods for this type of measurement to explain the sensitivity of the present technique and we also make a prediction for the ultimate sensitivity for the resonator $Q$ and $f_0$ determination.
Magnetic nanoparticles are promising systems for biomedical applications and in particular for Magnetic Fluid Hyperthermia, a promising therapy that utilizes the heat released by such systems to damage tumor cells. We present an experimental study of the physical properties that influences the capability of heat release, i.e. the Specific Loss Power, SLP, of three biocompatible ferrofluid samples having a magnetic core of maghemite with different core diameter d= 10.2, 14.6 and 19.7 nm. The SLP was measured as a function of frequency f and intensity of the applied alternating magnetic field H, and it turned out to depend on the core diameter, as expected. The results allowed us to highlight experimentally that the physical mechanism responsible for the heating is size-dependent and to establish, at applied constant frequency, the phenomenological functional relationship SLP=cH^x, with 2<x<3 for all samples. The x-value depends on sample size and field frequency/ intensity, here chosen in the typical range of operating magnetic hyperthermia devices. For the smallest sample, the effective relaxation time Teff=19.5 ns obtained from SLP data is in agreement with the value estimated from magnetization data, thus confirming the validity of the Linear Response Theory model for this system at properly chosen field intensity and frequency.
After 26 years in outburst, the black hole X-ray binary GRS 1915+105 dimmed considerably in early 2018; its flux dropped sharply in mid-2019, and it has remained faint ever since. This faint period, the obscured state, is punctuated by occasional X-ray flares, many of which have been observed by NICER as part of our regular monitoring program. Here we present detailed time-resolved spectroscopy of one bright flare, whose spectrum shows evidence of high column density partial covering absorption and extremely deep absorption lines (equivalent widths over 100 eV in some cases). We study the time-dependent ionization of the obscuring gas with XSTAR, ultimately attributing the absorption to a radially-stratified absorber of density 1e12-1e13 cm^-3 at a ~few x 1e11 cm from the black hole. We argue that a vertically-extended outer disk could explain this obscuration. We discuss several scenarios to explain the obscured state, including massive outflows, an increase in the mass accretion rate, and changes in the outer disk that herald the approach of quiescence, but none are entirely satisfactory. Alternative explanations, such as obscuration by the accretion stream impact point, may be testable with current or future data.
Au and Pt do not form homogeneous bulk alloys as they are thermodynamically not miscible. However, we show that anodic TiO$_2$ nanotubes (NTs) can in-situ be uniformly decorated with homogeneous AuPt alloy nanoparticles (NPs) during their anodic growth. For this, a metallic Ti substrate containing low amounts of dissolved Au (0.1 at%) and Pt (0.1 at%) is used for anodizing. The matrix metal (Ti) is converted to oxide while at the oxide/metal interface direct noble metal particle formation and alloying of Au and Pt takes place; continuously these particles are then picked up by the growing nanotube wall. In our experiments the AuPt alloy NPs have an average size of 4.2 nm and, at the end of the anodic process, are regularly dispersed over the TiO$_2$ nanotubes. These alloyed AuPt particles act as excellent co-catalyst in photocatalytic H2 generation - with a H2 production of 12.04 {mu}L h-1 under solar light. This represents a strongly enhanced activity as compared with TiO$_2$ NTs decorated with monometallic particles of Au (7 {mu}L h-1) or Pt (9.96 {mu}L h-1).
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