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Register a new userNoisy network attractor models for transitions between EEG microstates
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The brain is intrinsically organized into large-scale networks that constantly re-organize on multiple timescales, even when the brain is at rest. The timing of these dynamics is crucial for sensation, perception, cognition and ultimately consciousness, but the underlying dynamics governing the constant reorganization and switching between networks are not yet well understood. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) provide anatomical and temporal information about the resting-state networks (RSNs), respectively. EEG microstates are brief periods of stable scalp topography, and four distinct configurations with characteristic switching patterns between them are reliably identified at rest. Microstates have been identified as the electrophysiological correlate of fMRI-defined RSNs, this link could be established because EEG microstate sequences are scale-free and have long-range temporal correlations. This property is crucial for any approach to model EEG microstates. This paper proposes a novel modeling approach for microstates: we consider nonlinear stochastic differential equations (SDEs) that exhibit a noisy network attractor between nodes that represent the microstates. Using a single layer network between four states, we can reproduce the transition probabilities between microstates but not the heavy tailed residence time distributions. Introducing a two layer network with a hidden layer gives the flexibility to capture these heavy tails and their long-range temporal correlations. We fit these models to capture the statistical properties of microstate sequences from EEG data recorded inside and outside the MRI scanner and show that the processing required to separate the EEG signal from the fMRI machine noise results in a loss of information which is reflected in differences in the long tail of the dwell-time distributions.
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Simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can be used to non-invasively measure the spatiotemporal dynamics of the human brain. One challenge is dealing with the artifacts that each modality introduces into the other when the two are recorded concurrently, for example the ballistocardiogram (BCG). We conducted a preliminary comparison of three different MR compatible EEG recording systems and assessed their performance in terms of single-trial classification of the EEG when simultaneously collecting fMRI. We found tradeoffs across all three systems, for example varied ease of setup and improved classification accuracy with reference electrodes (REF) but not for pulse artifact subtraction (PAS) or reference layer adaptive filtering (RLAF).
We present a theoretical application of an optimal experiment design (OED) methodology to the development of mathematical models to describe the stimulus-response relationship of sensory neurons. Although there are a few related studies in the computational neuroscience literature on this topic, most of them are either involving non-linear static maps or simple linear filters cascaded to a static non-linearity. Although the linear filters might be appropriate to demonstrate some aspects of neural processes, the high level of non-linearity in the nature of the stimulus-response data may render them inadequate. In addition, modelling by a static non-linear input - output map may mask important dynamical (time-dependent) features in the response data. Due to all those facts a non-linear continuous time dynamic recurrent neural network that models the excitatory and inhibitory membrane potential dynamics is preferred. The main goal of this research is to estimate the parametric details of this model from the available stimulus-response data. In order to design an efficient estimator an optimal experiment design scheme is proposed which computes a pre-shaped stimulus to maximize a certain measure of Fisher Information Matrix. This measure depends on the estimated values of the parameters in the current step and the optimal stimuli are used in a maximum likelihood estimation procedure to find an estimate of the network parameters. This process works as a loop until a reasonable convergence occurs. The response data is discontinuous as it is composed of the neural spiking instants which is assumed to obey the Poisson statistical distribution. Thus the likelihood functions depend on the Poisson statistics. In order to validate the approach and evaluate its performance, a comparison with another approach on estimation based on randomly generated stimuli is also presented.
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Predicting post-operative seizure freedom using functional correlation networks derived from interictal intracranial EEG has shown some success. However, there are important challenges to consider. 1: electrodes physically closer to each other naturally tend to be more correlated causing a spatial bias. 2: implantation location and number of electrodes differ between patients, making cross-subject comparisons difficult. 3: functional correlation networks can vary over time but are currently assumed as static. In this study we address these three substantial challenges using intracranial EEG data from 55 patients with intractable focal epilepsy. Patients additionally underwent preoperative MR imaging, intra-operative CT, and post-operative MRI allowing accurate localisation of electrodes and delineation of removed tissue. We show that normalising for spatial proximity between nearby electrodes improves prediction of post-surgery seizure outcomes. Moreover, patients with more extensive electrode coverage were more likely to have their outcome predicted correctly (ROC-AUC >0.9, p<<0.05), but not necessarily more likely to have a better outcome. Finally, our predictions are robust regardless of the time segment. Future studies should account for the spatial proximity of electrodes in functional network construction to improve prediction of post-surgical seizure outcomes. Greater coverage of both removed and spared tissue allows for predictions with higher accuracy.
The study of electroencephalographic (EEG) bursts in preterm infants provides valuable information about maturation or prognostication after perinatal asphyxia. Over the last two decades, a number of works proposed algorithms to automatically detect EEG bursts in preterm infants, but they were designed for populations under 35 weeks of post menstrual age (PMA). However, as the brain activity evolves rapidly during postnatal life, these solutions might be under-performing with increasing PMA. In this work we focused on preterm infants reaching term ages (PMA $geq$ 36 weeks) using multi-feature classification on a single EEG channel. Five EEG burst detectors relying on different machine learning approaches were compared: Logistic regression (LR), linear discriminant analysis (LDA), k-nearest neighbors (kNN), support vector machines (SVM) and thresholding (Th). Classifiers were trained by visually labeled EEG recordings from 14 very preterm infants (born after 28 weeks of gestation) with 36 - 41 weeks PMA. The most performing classifiers reached about 95% accuracy (kNN, SVM and LR) whereas Th obtained 84%. Compared to human-automatic agreements, LR provided the highest scores (Cohens kappa = 0.71) and the best computational efficiency using only three EEG features. Applying this classifier in a test database of 21 infants $geq$ 36 weeks PMA, we show that long EEG bursts and short inter-bust periods are characteristic of infants with the highest PMA and weights. In view of these results, LR-based burst detection could be a suitable tool to study maturation in monitoring or portable devices using a single EEG channel.
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