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Register a new userConstrained inference through posterior projections
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Added by
Deborshee Sen
Publication date
2018
fields
Mathematical Statistics
and research's language is
English
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Bayesian approaches are appealing for constrained inference problems in allowing a probabilistic characterization of uncertainty, while providing a computational machinery for incorporating complex constraints in hierarchical models. However, the usual Bayesian strategy of placing a prior on the constrained space and conducting posterior computation with Markov chain Monte Carlo algorithms is often intractable. An alternative is to conduct inference for a less constrained posterior and project samples to the constrained space through a minimal distance mapping. We formalize and provide a unifying framework for such posterior projections. For theoretical tractability, we initially focus on constrained parameter spaces corresponding to closed and convex subsets of the original space. We then consider non-convex Stiefel manifolds. We provide a general formulation of the projected posterior and show that it can be viewed as an update of a data-dependent prior with the likelihood for particular classes of priors and likelihood functions. We also show that asymptotic properties of the unconstrained posterior are transferred to the projected posterior. Posterior projections are illustrated through multiple examples, both in simulation studies and real data applications.
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A local projection is a statistical framework that accounts for the relationship between an exogenous variable and an endogenous variable, measured at different time points. Local projections are often applied in impulse response analyses and direct forecasting. While local projections are becoming increasingly popular because of their robustness to misspecification and their flexibility, they are less statistically efficient than standard methods, such as vector autoregression. In this study, we seek to improve the statistical efficiency of local projections by developing a fully Bayesian approach that can be used to estimate local projections using roughness penalty priors. By incorporating such prior-induced smoothness, we can use information contained in successive observations to enhance the statistical efficiency of an inference. We apply the proposed approach to an analysis of monetary policy in the United States, showing that the roughness penalty priors successfully estimate the impulse response functions and improve the predictive accuracy of local projections.
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Cluster randomized controlled trials (cRCTs) are designed to evaluate interventions delivered to groups of individuals. A practical limitation of such designs is that the number of available clusters may be small, resulting in an increased risk of baseline imbalance under simple randomization. Constrained randomization overcomes this issue by restricting the allocation to a subset of randomization schemes where sufficient overall covariate balance across comparison arms is achieved with respect to a pre-specified balance metric. However, several aspects of constrained randomization for the design and analysis of multi-arm cRCTs have not been fully investigated. Motivated by an ongoing multi-arm cRCT, we provide a comprehensive evaluation of the statistical properties of model-based and randomization-based tests under both simple and constrained randomization designs in multi-arm cRCTs, with varying combinations of design and analysis-based covariate adjustment strategies. In particular, as randomization-based tests have not been extensively studied in multi-arm cRCTs, we additionally develop most-powerful permutation tests under the linear mixed model framework for our comparisons. Our results indicate that under constrained randomization, both model-based and randomization-based analyses could gain power while preserving nominal type I error rate, given proper analysis-based adjustment for the baseline covariates. The choice of balance metrics and candidate set size and their implications on the testing of the pairwise and global hypotheses are also discussed. Finally, we caution against the design and analysis of multi-arm cRCTs with an extremely small number of clusters, due to insufficient degrees of freedom and the tendency to obtain an overly restricted randomization space.
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