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Register a new userCorresponding Projections for Orphan Screening
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We propose a novel transfer learning approach for orphan screening called corresponding projections. In orphan screening the learning task is to predict the binding affinities of compounds to an orphan protein, i.e., one for which no training data is available. The identification of compounds with high affinity is a central concern in medicine since it can be used for drug discovery and design. Given a set of prediction models for proteins with labelled training data and a similarity between the proteins, corresponding projections constructs a model for the orphan protein from them such that the similarity between models resembles the one between proteins. Under the assumption that the similarity resemblance holds, we derive an efficient algorithm for kernel methods. We empirically show that the approach outperforms the state-of-the-art in orphan screening.
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This paper focusses on safe screening techniques for the LASSO problem. Motivated by the need for low-complexity algorithms, we propose a new approach, dubbed joint screening test, allowing to screen a set of atoms by carrying out one single test. The approach is particularized to two different sets of atoms, respectively expressed as sphere and dome regions. After presenting the mathematical derivations of the tests, we elaborate on their relative effectiveness and discuss the practical use of such procedures.
The sparse representation classifier (SRC) is shown to work well for image recognition problems that satisfy a subspace assumption. In this paper we propose a new implementation of SRC via screening, establish its equivalence to the original SRC under regularity conditions, and prove its classification consistency for random graphs drawn from stochastic blockmodels. The results are demonstrated via simulations and real data experiments, where the new algorithm achieves comparable numerical performance but significantly faster.
Inspired by the advances in biological science, the study of sparse binary projection models has attracted considerable recent research attention. The models project dense input samples into a higher-dimensional space and output sparse binary data representations after the Winner-Take-All competition, subject to the constraint that the projection matrix is also sparse and binary. Following the work along this line, we developed a supervised-WTA model when training samples with both input and output representations are available, from which the optimal projection matrix can be obtained with a simple, effective yet efficient algorithm. We further extended the model and the algorithm to an unsupervised setting where only the input representation of the samples is available. In a series of empirical evaluation on similarity search tasks, the proposed models reported significantly improved results over the state-of-the-art methods in both search accuracies and running speed. The successful results give us strong confidence that the work provides a highly practical tool to real world applications.
Classical methods for psychometric function estimation either require excessive measurements or produce only a low-resolution approximation of the target psychometric function. In this paper, we propose a novel solution for rapid screening for a change in the psychometric function estimation of a given patient. We use Bayesian active model selection to perform an automated pure-tone audiogram test with the goal of quickly finding if the current audiogram will be different from a previous audiogram. We validate our approach using audiometric data from the National Institute for Occupational Safety and Health NIOSH. Initial results show that with a few tones we can detect if the patients audiometric function has changed between the two test sessions with high confidence.
We propose two training techniques for improving the robustness of Neural Networks to adversarial attacks, i.e. manipulations of the inputs that are maliciously crafted to fool networks into incorrect predictions. Both methods are independent of the chosen attack and leverage random projections of the original inputs, with the purpose of exploiting both dimensionality reduction and some characteristic geometrical properties of adversarial perturbations. The first technique is called RP-Ensemble and consists of an ensemble of networks trained on multiple project
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