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Geometric characterization of data sets with unique reduced Grobner bases

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 Added by Anyu Zhang
 Publication date 2018
  fields
and research's language is English




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Model selection based on experimental data is an important challenge in biological data science. Particularly when collecting data is expensive or time consuming, as it is often the case with clinical trial and biomolecular experiments, the problem of selecting information-rich data becomes crucial for creating relevant models. We identify geometric properties of input data that result in a unique algebraic model and we show that if the data form a staircase, or a so-called linear shift of a staircase, the ideal of the points has a unique reduced Gro bner basis and thus corresponds to a unique model. We use linear shifts to partition data into equivalence classes with the same basis. We demonstrate the utility of the results by applying them to a Boolean model of the well-studied lac operon in E. coli.



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In the field of algebraic systems biology, the number of minimal polynomial models constructed using discretized data from an underlying system is related to the number of distinct reduced Grobner bases for the ideal of the data points. While the theory of Grobner bases is extensive, what is missing is a closed form for their number for a given ideal. This work contributes connections between the geometry of data points and the number of Grobner bases associated to small data sets. Furthermore we improve an existing upper bound for the number of Grobner bases specialized for data over a finite field.
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