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Register a new userMedAL: Deep Active Learning Sampling Method for Medical Image Analysis
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Added by
Devesh Walawalkar
Publication date
2018
fields
Informatics Engineering
and research's language is
English
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Deep learning models have been successfully used in medical image analysis problems but they require a large amount of labeled images to obtain good performance.Deep learning models have been successfully used in medical image analysis problems but they require a large amount of labeled images to obtain good performance. However, such large labeled datasets are costly to acquire. Active learning techniques can be used to minimize the number of required training labels while maximizing the models performance.In this work, we propose a novel sampling method that queries the unlabeled examples that maximize the average distance to all training set examples in a learned feature space. We then extend our sampling method to define a better initial training set, without the need for a trained model, by using ORB feature descriptors. We validate MedAL on 3 medical image datasets and show that our method is robust to different dataset properties. MedAL is also efficient, achieving 80% accuracy on the task of Diabetic Retinopathy detection using only 425 labeled images, corresponding to a 32% reduction in the number of required labeled examples compared to the standard uncertainty sampling technique, and a 40% reduction compared to random sampling.
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Active Learning methods create an optimized labeled training set from unlabeled data. We introduce a novel Online Active Deep Learning method for Medical Image Analysis. We extend our MedAL active learning framework to present new results in this paper. Our novel sampling method queries the unlabeled examples that maximize the average distance to all training set examples. Our online method enhances performance of its underlying baseline deep network. These novelties contribute significant performance improvements, including improving the models underlying deep network accuracy by 6.30%, using only 25% of the labeled dataset to achieve baseline accuracy, reducing backpropagated images during training by as much as 67%, and demonstrating robustness to class imbalance in binary and multi-class tasks.
Medical image analysis typically includes several tasks such as enhancement, segmentation, and classification. Traditionally, these tasks are implemented using separate deep learning models for separate tasks, which is not efficient because it involves unnecessary training repetitions, demands greater computational resources, and requires a relatively large amount of labeled data. In this paper, we propose a multi-task training approach for medical image analysis, where individual tasks are fine-tuned simultaneously through relevant knowledge transfer using a unified modality-specific feature representation (UMS-Rep). We explore different fine-tuning strategies to demonstrate the impact of the strategy on the performance of target medical image tasks. We experiment with different visual tasks (e.g., image denoising, segmentation, and classification) to highlight the advantages offered with our approach for two imaging modalities, chest X-ray and Doppler echocardiography. Our results demonstrate that the proposed approach reduces the overall demand for computational resources and improves target task generalization and performance. Further, our results prove that the performance of target tasks in medical images is highly influenced by the utilized fine-tuning strategy.
Deep neural networks (DNNs) have become popular for medical image analysis tasks like cancer diagnosis and lesion detection. However, a recent study demonstrates that medical deep learning systems can be compromised by carefully-engineered adversarial examples/attacks with small imperceptible perturbations. This raises safety concerns about the deployment of these systems in clinical settings. In this paper, we provide a deeper understanding of adversarial examples in the context of medical images. We find that medical DNN models can be more vulnerable to adversarial attacks compared to models for natural images, according to two different viewpoints. Surprisingly, we also find that medical adversarial attacks can be easily detected, i.e., simple detectors can achieve over 98% detection AUC against state-of-the-art attacks, due to fundamental feature differences compared to normal examples. We believe these findings may be a useful basis to approach the design of more explainable and secure medical deep learning systems.
The accuracy and robustness of image classification with supervised deep learning are dependent on the availability of large-scale, annotated training data. However, there is a paucity of annotated data available due to the complexity of manual annotation. To overcome this problem, a popular approach is to use transferable knowledge across different domains by: 1) using a generic feature extractor that has been pre-trained on large-scale general images (i.e., transfer-learned) but which not suited to capture characteristics from medical images; or 2) fine-tuning generic knowledge with a relatively smaller number of annotated images. Our aim is to reduce the reliance on annotated training data by using a new hierarchical unsupervised feature extractor with a convolutional auto-encoder placed atop of a pre-trained convolutional neural network. Our approach constrains the rich and generic image features from the pre-trained domain to a sophisticated representation of the local image characteristics from the unannotated medical image domain. Our approach has a higher classification accuracy than transfer-learned approaches and is competitive with state-of-the-art supervised fine-tuned methods.
Deep learning has become the mainstream technology in computer vision, and it has received extensive research interest in developing new medical image processing algorithms to support disease detection and diagnosis. As compared to conventional machine learning technologies, the major advantage of deep learning is that models can automatically identify and recognize representative features through the hierarchal model architecture, while avoiding the laborious development of hand-crafted features. In this paper, we reviewed and summarized more than 200 recently published papers to provide a comprehensive overview of applying deep learning methods in various medical image analysis tasks. Especially, we emphasize the latest progress and contributions of state-of-the-art unsupervised and semi-supervised deep learning in medical images, which are summarized based on different application scenarios, including lesion classification, segmentation, detection, and image registration. Additionally, we also discussed the major technical challenges and suggested the possible solutions in future research efforts.
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