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Register a new userDeep Graph Laplacian Regularization for Robust Denoising of Real Images
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Added by
Jiahao Pang
Publication date
2018
fields
Informatics Engineering
and research's language is
English
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Recent developments in deep learning have revolutionized the paradigm of image restoration. However, its applications on real image denoising are still limited, due to its sensitivity to training data and the complex nature of real image noise. In this work, we combine the robustness merit of model-based approaches and the learning power of data-driven approaches for real image denoising. Specifically, by integrating graph Laplacian regularization as a trainable module into a deep learning framework, we are less susceptible to overfitting than pure CNN-based approaches, achieving higher robustness to small datasets and cross-domain denoising. First, a sparse neighborhood graph is built from the output of a convolutional neural network (CNN). Then the image is restored by solving an unconstrained quadratic programming problem, using a corresponding graph Laplacian regularizer as a prior term. The proposed restoration pipeline is fully differentiable and hence can be end-to-end trained. Experimental results demonstrate that our work is less prone to overfitting given small training data. It is also endowed with strong cross-domain generalization power, outperforming the state-of-the-art approaches by a remarkable margin.
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3D point cloud - a new signal representation of volumetric objects - is a discrete collection of triples marking exterior object surface locations in 3D space. Conventional imperfect acquisition processes of 3D point cloud - e.g., stereo-matching from multiple viewpoint images or depth data acquired directly from active light sensors - imply non-negligible noise in the data. In this paper, we adopt a previously proposed low-dimensional manifold model for the surface patches in the point cloud and seek self-similar patches to denoise them simultaneously using the patch manifold prior. Due to discrete observations of the patches on the manifold, we approximate the manifold dimension computation defined in the continuous domain with a patch-based graph Laplacian regularizer and propose a new discrete patch distance measure to quantify the similarity between two same-sized surface patches for graph construction that is robust to noise. We show that our graph Laplacian regularizer has a natural graph spectral interpretation, and has desirable numerical stability properties via eigenanalysis. Extensive simulation results show that our proposed denoising scheme can outperform state-of-the-art methods in objective metrics and can better preserve visually salient structural features like edges.
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Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence microscopy images, it is highly desirable to have effective denoising algorithms and datasets that are specifically designed to denoise fluorescence microscopy images. While such algorithms exist, no such datasets are available. In this paper, we fill this gap by constructing a dataset - the Fluorescence Microscopy Denoising (FMD) dataset - that is dedicated to Poisson-Gaussian denoising. The dataset consists of 12,000 real fluorescence microscopy images obtained with commercial confocal, two-photon, and wide-field microscopes and representative biological samples such as cells, zebrafish, and mouse brain tissues. We use image averaging to effectively obtain ground truth images and 60,000 noisy images with different noise levels. We use this dataset to benchmark 10 representative denoising algorithms and find that deep learning methods have the best performance. To our knowledge, this is the first real microscopy image dataset for Poisson-Gaussian denoising purposes and it could be an important tool for high-quality, real-time denoising applications in biomedical research.
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