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Register a new userAn efficient dual sampling algorithm with Hamming distance filtration
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Recently, a framework considering RNA sequences and their RNA secondary structures as pairs, led to some information-theoretic perspectives on how the semantics encoded in RNA sequences can be inferred. In this context, the pairing arises naturally from the energy model of RNA secondary structures. Fixing the sequence in the pairing produces the RNA energy landscape, whose partition function was discovered by McCaskill. Dually, fixing the structure induces the energy landscape of sequences. The latter has been considered for designing more efficient inverse folding algorithms. We present here the Hamming distance filtered, dual partition function, together with a Boltzmann sampler using novel dynamic programming routines for the loop-based energy model. The time complexity of the algorithm is $O(h^2n)$, where $h,n$ are Hamming distance and sequence length, respectively, reducing the time complexity of samplers, reported in the literature by $O(n^2)$. We then present two applications, the first being in the context of the evolution of natural sequence-structure pairs of microRNAs and the second constructing neutral paths. The former studies the inverse fold rate (IFR) of sequence-structure pairs, filtered by Hamming distance, observing that such pairs evolve towards higher levels of robustness, i.e.,~increasing IFR. The latter is an algorithm that constructs neutral paths: given two sequences in a neutral network, we employ the sampler in order to construct short paths connecting them, consisting of sequences all contained in the neutral network.
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It is an open question whether there exists a polynomial-time algorithm for computing the rotation distances between pairs of extended ordered binary trees. The problem of computing the rotation distance between an arbitrary pair of trees, (S, T), can be efficiently reduced to the problem of computing the rotation distance between a difficult pair of trees (S, T), where there is no known first step which is guaranteed to be the beginning of a minimal length path. Of interest, therefore, is how to sample such difficult pairs of trees of a fixed size. We show that it is possible to do so efficiently, and present such an algorithm that runs in time $O(n^4)$.
X3SAT is the problem of whether one can satisfy a given set of clauses with up to three literals such that in every clause, exactly one literal is true and the others are false. A related question is to determine the maximal Hamming distance between two solutions of the instance. Dahllof provided an algorithm for Maximum Hamming Distance XSAT, which is more complicated than the same problem for X3SAT, with a runtime of $O(1.8348^n)$; Fu, Zhou and Yin considered Maximum Hamming Distance for X3SAT and found for this problem an algorithm with runtime $O(1.6760^n)$. In this paper, we propose an algorithm in $O(1.3298^n)$ time to solve the Max Hamming Distance X3SAT problem; the algorithm actually counts for each $k$ the number of pairs of solutions which have Hamming Distance $k$.
We consider the problem of sampling from a density of the form $p(x) propto exp(-f(x)- g(x))$, where $f: mathbb{R}^d rightarrow mathbb{R}$ is a smooth and strongly convex function and $g: mathbb{R}^d rightarrow mathbb{R}$ is a convex and Lipschitz function. We propose a new algorithm based on the Metropolis-Hastings framework, and prove that it mixes to within TV distance $varepsilon$ of the target density in at most $O(d log (d/varepsilon))$ iterations. This guarantee extends previous results on sampling from distributions with smooth log densities ($g = 0$) to the more general composite non-smooth case, with the same mixing time up to a multiple of the condition number. Our method is based on a novel proximal-based proposal distribution that can be efficiently computed for a large class of non-smooth functions $g$.
We demonstrate how boson sampling with photons of partial distinguishability can be expressed in terms of interference of fewer photons. We use this observation to propose a classical algorithm to simulate the output of a boson sampler fed with photons of partial distinguishability. We find conditions for which this algorithm is efficient, which gives a lower limit on the required indistinguishability to demonstrate a quantum advantage. Under these conditions, adding more photons only polynomially increases the computational cost to simulate a boson sampling experiment.
This work reports on two related investigations of stochastic simulations which are widely used to study biodiversity and other related issues. We first deal with the behavior of the Hamming distance under the increase of the number of species and the size of the lattice, and then investigate how the mobility of the species contributes to jeopardize biodiversity. The investigations are based on the standard rules of reproduction, mobility and predation or competition, which are described by specific rules, guided by generalization of the rock-paper-scissors game, valid in the case of three species. The results on the Hamming distance indicate that it engenders universal behavior, independently of the number of species and the size of the square lattice. The results on the mobility confirm the prediction that it may destroy diversity, if it is increased to higher and higher values.
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