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Register a new userComparison of hazard rate estimation in R
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Added by
Yolanda Hagar
Publication date
2015
fields
Mathematical Statistics
and research's language is
English
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We give an overview of eight different software packages and functions available in R for semi- or non-parametric estimation of the hazard rate for right-censored survival data. Of particular interest is the accuracy of the estimation of the hazard rate in the presence of covariates, as well as the user-friendliness of the packages. In addition, we investigate the ability to incorporate covariates under both the proportional and the non-proportional hazards assumptions. We contrast the robustness, variability and precision of the functions through simulations, and then further compare differences between the functions by analyzing the cancer and TRACE survival data sets available in R, including covariates under the proportional and non-proportional hazards settings.
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In epidemiological or demographic studies, with variable age at onset, a typical quantity of interest is the incidence of a disease (for example the cancer incidence). In these studies, the individuals are usually highly heterogeneous in terms of dates of birth (the cohort) and with respect to the calendar time (the period) and appropriate estimation methods are needed. In this article a new estimation method is presented which extends classical age-period-cohort analysis by allowing interactions between age, period and cohort effects. This paper introduces a bidimensional regularized estimate of the hazard rate where a penalty is introduced on the likelihood of the model. This penalty can be designed either to smooth the hazard rate or to enforce consecutive values of the hazard to be equal, leading to a parsimonious representation of the hazard rate. In the latter case, we make use of an iterative penalized likelihood scheme to approximate the L0 norm, which makes the computation tractable. The method is evaluated on simulated data and applied on breast cancer survival data from the SEER program.
In this paper we describe an algorithm for predicting the websites at risk in a long range hacking activity, while jointly inferring the provenance and evolution of vulnerabilities on websites over continuous time. Specifically, we use hazard regression with a time-varying additive hazard function parameterized in a generalized linear form. The activation coefficients on each feature are continuous-time functions constrained with total variation penalty inspired by hacking campaigns. We show that the optimal solution is a 0th order spline with a finite number of adaptively chosen knots, and can be solved efficiently. Experiments on real data show that our method significantly outperforms classic methods while providing meaningful interpretability.
In this paper, we develop a new estimation procedure based on the non-linear conjugate gradient (NCG) algorithm for the Box-Cox transformation cure rate model. We compare the performance of the NCG algorithm with the well-known expectation maximization (EM) algorithm through a simulation study and show the advantages of the NCG algorithm over the EM algorithm. In particular, we show that the NCG algorithm allows simultaneous maximization of all model parameters when the likelihood surface is flat with respect to a Box-Cox model parameter. This is a big advantage over the EM algorithm, where a profile likelihood approach has been proposed in the literature that may not provide satisfactory results. We finally use the NCG algorithm to analyze a well-known melanoma data and show that it results in a better fit.
In network analysis, many community detection algorithms have been developed, however, their implementation leaves unaddressed the question of the statistical validation of the results. Here we present robin(ROBustness In Network), an R package to assess the robustness of the community structure of a network found by one or more methods to give indications about their reliability. The procedure initially detects if the community structure found by a set of algorithms is statistically significant and then compares two selected detection algorithms on the same graph to choose the one that better fits the network of interest. We demonstrate the use of our package on the American College Football benchmark dataset.
This paper proposes consistent and asymptotically Gaussian estimators for the drift, the diffusion coefficient and the Hurst exponent of the discretely observed fractional Ornstein-Uhlenbeck process. For the estimation of the drift, the results are obtained only in the case when 1/2 < H < 3/4. This paper also provides ready-to-use software for the R statistical environment based on the YUIMA package.
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