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Register a new userFrom Caenorhabditis elegans to the Human Connectome: A Specific Modular Organisation Increases Metabolic, Functional, and Developmental Efficiency
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The connectome, or the entire connectivity of a neural system represented by network, ranges various scales from synaptic connections between individual neurons to fibre tract connections between brain regions. Although the modularity they commonly show has been extensively studied, it is unclear whether connection specificity of such networks can already be fully explained by the modularity alone. To answer this question, we study two networks, the neuronal network of C. elegans and the fibre tract network of human brains yielded through diffusion spectrum imaging (DSI). We compare them to their respective benchmark networks with varying modularities, which are generated by link swapping to have desired modularity values but otherwise maximally random. We find several network properties that are specific to the neural networks and cannot be fully explained by the modularity alone. First, the clustering coefficient and the characteristic path length of C. elegans and human connectomes are both higher than those of the benchmark networks with similar modularity. High clustering coefficient indicates efficient local information distribution and high characteristic path length suggests reduced global integration. Second, the total wiring length is smaller than for the alternative configurations with similar modularity. This is due to lower dispersion of connections, which means each neuron in C. elegans connectome or each region of interest (ROI) in human connectome reaches fewer ganglia or cortical areas, respectively. Third, both neural networks show lower algorithmic entropy compared to the alternative arrangements. This implies that fewer rules are needed to encode for the organisation of neural systems.
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Graph theoretical analyses of nervous systems usually omit the aspect of connection polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans is a well-reconstructed directed network, but the signs of its connections are yet to be elucidated. Here, we present the gene expression-based sign prediction of the ionotropic chemical synapse connectome of C. elegans (3,638 connections and 20,589 synapses total), incorporating available presynaptic neurotransmitter and postsynaptic receptor gene expression data for three major neurotransmitter systems. We made predictions for more than two-thirds of these chemical synapses and observed an excitatory-inhibitory (E:I) ratio close to 4:1 which was found similar to that observed in many real-world networks. Our open source tool (http://EleganSign.linkgroup.hu) is simple but efficient in predicting polarities by integrating neuronal connectome and gene expression data.
As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. We use a network representation of diffusion imaging data from 882 youth ages 8 to 22 to show that white matter connectivity becomes increasingly optimized for a diverse range of predicted dynamics in development. Notably, stable controllers in subcortical areas are negatively related to cognitive performance. Investigating structural mechanisms supporting these changes, we simulate network evolution with a set of growth rules. We find that all brain networks are structured in a manner highly optimized for network control, with distinct control mechanisms predicted in child versus older youth. We demonstrate that our results cannot be simply explained by changes in network modularity. This work reveals a possible mechanism of human brain development that preferentially optimizes dynamic network control over static network architecture.
Graph spectral analysis can yield meaningful embeddings of graphs by providing insight into distributed features not directly accessible in nodal domain. Recent efforts in graph signal processing have proposed new decompositions-e.g., based on wavelets and Slepians-that can be applied to filter signals defined on the graph. In this work, we take inspiration from these constructions to define a new guided spectral embedding that combines maximizing energy concentration with minimizing modified embedded distance for a given importance weighting of the nodes. We show these optimization goals are intrinsically opposite, leading to a well-defined and stable spectral decomposition. The importance weighting allows to put the focus on particular nodes and tune the trade-off between global and local effects. Following the derivation of our new optimization criterion and its linear approximation, we exemplify the methodology on the C. elegans structural connectome. The results of our analyses confirm known observations on the nematodes neural network in terms of functionality and importance of cells. Compared to Laplacian embedding, the guided approach, focused on a certain class of cells (sensory, inter- and motoneurons), provides more biological insights, such as the distinction between somatic positions of cells, and their involvement in low or high order processing functions.
Functional connectivity quantifies the statistical dependencies between the activity of brain regions, measured using neuroimaging data such as functional MRI BOLD time series. The network representation of functional connectivity, called a Functional Connectome (FC), has been shown to contain an individual fingerprint allowing participants identification across consecutive testing sessions. Recently, researchers have focused on the extraction of these fingerprints, with potential applications in personalized medicine. Here, we show that a mathematical operation denominated degree-normalization can improve the extraction of FC fingerprints. Degree-normalization has the effect of reducing the excessive influence of strongly connected brain areas in the whole-brain network. We adopt the differential identifiability framework and apply it to both original and degree-normalized FCs of 409 individuals from the Human Connectome Project, in resting-state and 7 fMRI tasks. Our results indicate that degree-normalization systematically improves three fingerprinting metrics, namely differential identifiability, identification rate and matching rate. Moreover, the results related to the matching rate metric suggest that individual fingerprints are embedded in a low-dimensional space. The results suggest that low-dimensional functional fingerprints lie in part in weakly connected subnetworks of the brain, and that degree-normalization helps uncovering them. This work introduces a simple mathematical operation that could lead to significant improvements in future FCs fingerprinting studies.
The frequency-specific coupling mechanism of the functional human brain networks underpins its complex cognitive and behavioral functions. Nevertheless, it is not well unveiled what are the frequency-specific subdivisions and network topologies of the human brain. In this study, we estimated functional connectivity of the human cerebral cortex using spectral connection, and conducted frequency-specific parcellation using eigen-clustering and gradient-based methods, and then explored their topological structures. 7T fMRI data of 184 subjects in the HCP dataset were used for parcellation and exploring the topological properties of the functional networks, and 3T fMRI data of another 890 subjects were used to confirm the stability of the frequency-specific topologies. Seven to ten functional networks were stably integrated by two to four dissociable hub categories at specific frequencies, and we proposed an intrinsic functional atlas containing 456 parcels according to the parcellations across frequencies. The results revealed that the functional networks contained stable frequency-specific topologies, which may imply more abundant roles of the functional units and more complex interactions among them.
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