Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userStatistical Inference on Transformation Models: a Self-induced Smoothing Approach
271
0
0.0
(
0
)
Added by
Junyi Zhang
Publication date
2013
fields
Mathematical Statistics
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
This paper deals with a general class of transformation models that contains many important semiparametric regression models as special cases. It develops a self-induced smoothing for the maximum rank correlation estimator, resulting in simultaneous point and variance estimation. The self-induced smoothing does not require bandwidth selection, yet provides the right amount of smoothness so that the estimator is asymptotically normal with mean zero (unbiased) and variance-covariance matrix consistently estimated by the usual sandwich-type estimator. An iterative algorithm is given for the variance estimation and shown to numerically converge to a consistent limiting variance estimator. The approach is applied to a data set involving survival times of primary biliary cirrhosis patients. Simulations results are reported, showing that the new method performs well under a variety of scenarios.
rate research
Read More
The focus of modern biomedical studies has gradually shifted to explanation and estimation of joint effects of high dimensional predictors on disease risks. Quantifying uncertainty in these estimates may provide valuable insight into prevention strategies or treatment decisions for both patients and physicians. High dimensional inference, including confidence intervals and hypothesis testing, has sparked much interest. While much work has been done in the linear regression setting, there is lack of literature on inference for high dimensional generalized linear models. We propose a novel and computationally feasible method, which accommodates a variety of outcome types, including normal, binomial, and Poisson data. We use a splitting and smoothing approach, which splits samples into two parts, performs variable selection using one part and conducts partial regression with the other part. Averaging the estimates over multiple random splits, we obtain the smoothed estimates, which are numerically stable. We show that the estimates are consistent, asymptotically normal, and construct confidence intervals with proper coverage probabilities for all predictors. We examine the finite sample performance of our method by comparing it with the existing methods and applying it to analyze a lung cancer cohort study.
Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional fixed effects. The proposed method is applicable to general settings where the dimension of the random effects and the cluster sizes are possibly large. Regarding the fixed effects, we provide rate optimal estimators and valid inference procedures that do not rely on the structural information of the variance components. We also study the estimation of variance components with high-dimensional fixed effects in general settings. The algorithms are easy to implement and computationally fast. The proposed methods are assessed in various simulation settings and are applied to a real study regarding the associations between body mass index and genetic polymorphic markers in a heterogeneous stock mice population.
Regression models describing the joint distribution of multivariate response variables conditional on covariate information have become an important aspect of contemporary regression analysis. However, a limitation of such models is that they often rely on rather simplistic assumptions, e.g. a constant dependency structure that is not allowed to vary with the covariates or the restriction to linear dependence between the responses only. We propose a general framework for multivariate conditional transformation models that overcomes these limitations and describes the entire distribution in a tractable and interpretable yet flexible way conditional on nonlinear effects of covariates. The framework can be embedded into likelihood-based inference, including results on asymptotic normality, and allows the dependence structure to vary with covariates. In addition, the framework scales well beyond bivariate response situations, which were the main focus of most earlier investigations. We illustrate the application of multivariate conditional transformation models in a trivariate analysis of childhood undernutrition and demonstrate empirically that our approach can be beneficial compared to existing benchmarks such that complex truly multivariate data-generating processes can be inferred from observations.
Heterogeneity is an important feature of modern data sets and a central task is to extract information from large-scale and heterogeneous data. In this paper, we consider multiple high-dimensional linear models and adopt the definition of maximin effect (Meinshausen, B{u}hlmann, AoS, 43(4), 1801--1830) to summarize the information contained in this heterogeneous model. We define the maximin effect for a targeted population whose covariate distribution is possibly different from that of the observed data. We further introduce a ridge-type maximin effect to simultaneously account for reward optimality and statistical stability. To identify the high-dimensional maximin effect, we estimate the regression covariance matrix by a debiased estimator and use it to construct the aggregation weights for the maximin effect. A main challenge for statistical inference is that the estimated weights might have a mixture distribution and the resulted maximin effect estimator is not necessarily asymptotic normal. To address this, we devise a novel sampling approach to construct the confidence interval for any linear contrast of high-dimensional maximin effects. The coverage and precision properties of the proposed confidence interval are studied. The proposed method is demonstrated over simulations and a genetic data set on yeast colony growth under different environments.
We propose a methodology for filtering, smoothing and assessing parameter and filtering uncertainty in score-driven models. Our technique is based on a general representation of the Kalman filter and smoother recursions for linear Gaussian models in terms of the score of the conditional log-likelihood. We prove that, when data is generated by a nonlinear non-Gaussian state-space model, the proposed methodology results from a local expansion of the true filtering density. A formal characterization of the approximation error is provided. As shown in extensive Monte Carlo analyses, our methodology performs very similarly to exact simulation-based methods, while remaining computationally extremely simple. We illustrate empirically the advantages in employing score-driven models as approximate filters rather than purely predictive processes.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
