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Medical Application Studies at ELI-NP

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 Added by Peter Thirolf
 Publication date 2012
  fields
and research's language is English




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We study the production of radioisotopes for nuclear medicine in (gamma,gamma) photoexcitation reactions or (gamma,xn + yp) photonuclear reactions for the examples of ^195mPt, ^117mSn and ^44Ti with high flux [(10^13 - 10^15) gamma/s], small beam diameter and small energy band width (Delta E/E ~ 10^-3 -10^-4) gamma beams. In order to realize an optimum gamma-focal spot, a refractive gamma-lens consisting of a stack of many concave micro-lenses will be used. It allows for the production of a high specific activity and the use of enriched isotopes. For photonuclear reactions with a narrow gamma beam, the energy deposition in the target can be reduced by using a stack of thin target wires, hence avoiding direct stopping of the Compton electrons and e^+e^- pairs. The well-defined initial excitation energy of the compound nucleus leads to a small number of reaction channels and enables new combinations of target isotope and final radioisotope. The narrow-bandwidth gamma excitation may make use of collective resonances in gamma-width, leading to increased cross sections. (gamma,gamma) isomer production via specially selected gamma cascades allows to produce high specific activity in multiple excitations, where no back-pumping of the isomer to the ground state occurs. The produced isotopes will open the way for completely new clinical applications of radioisotopes. For example ^195mPt could be used to verify the patients response to chemotherapy with platinum compounds before a complete treatment is performed. In targeted radionuclide therapy the short-range Auger and conversion electrons of ^195mPt and ^117mSn enable a very local treatment. The generator ^44Ti allows for a PET with an additional gamma-quantum (gamma-PET), resulting in a reduced dose or better spatial resolution.



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We study and discuss electron acceleration in vacuum interacting with fundamental Gaussian pulses using specific parameters relevant for the multi-PW femtosecond lasers at ELI-NP. Taking into account the characteristic properties of both linearly and circularly polarized Gaussian beams near focus we have calculated the optimal values of beam waist leading to the most energetic electrons for given laser power. The optimal beam waist at full width at half maximum correspond to few tens of wavelengths, $Delta w_0=left{13,23,41right}lambda_0$, for increasing laser power $P_0 = left{0.1,1,10right}$ PW. Using these optimal values we found an average energy gain of a few MeV and highest-energy electrons of about $160$ MeV in full-pulse interactions and in the GeV range in case of half-pulse interaction.
The tagged quasi-free $np to nppi^+pi^-$ reaction has been studied experimentally with the High Acceptance Di-Electron Spectrometer (HADES) at GSI at a deuteron incident beam energy of 1.25 GeV/nucleon ($sqrt s sim$ 2.42 GeV/c for the quasi-free collision). For the first time, differential distributions for $pi^{+}pi^{-}$ production in $np$ collisions have been collected in the region corresponding to the large transverse momenta of the secondary particles. The invariant mass and angular distributions for the $nprightarrow nppi^{+}pi^{-}$ reaction are compared with different models. This comparison confirms the dominance of the $t$-channel with $DeltaDelta$ contribution. It also validates the changes previously introduced in the Valencia model to describe two-pion production data in other isospin channels, although some deviations are observed, especially for the $pi^{+}pi^{-}$ invariant mass spectrum. The extracted total cross section is also in much better agreement with this model. Our new measurement puts useful constraints for the existence of the conjectured dibaryon resonance at mass M$sim$ 2.38 GeV and with width $Gammasim$ 70 MeV.
The machine described in this document is an advanced Source of up to 20 MeV Gamma Rays based on Compton back-scattering, i.e. collision of an intense high power laser beam and a high brightness electron beam with maximum kinetic energy of about 720 MeV. Fully equipped with collimation and characterization systems, in order to generate, form and fully measure the physical characteristics of the produced Gamma Ray beam. The quality, i.e. phase space density, of the two colliding beams will be such that the emitted Gamma ray beam is characterized by energy tunability, spectral density, bandwidth, polarization, divergence and brilliance compatible with the requested performances of the ELI-NP user facility, to be built in Romania as the Nuclear Physics oriented Pillar of the European Extreme Light Infrastructure. This document illustrates the Technical Design finally produced by the EuroGammaS Collaboration, after a thorough investigation of the machine expected performances within the constraints imposed by the ELI-NP tender for the Gamma Beam System (ELI-NP-GBS), in terms of available budget, deadlines for machine completion and performance achievement, compatibility with lay-out and characteristics of the planned civil engineering.
The Gamma Beam System (GBS) is a high brightness LINAC to be installed in Magurele (Bucharest) at the new ELI-NP (Extreme Light Infrastructure - Nuclear Physics) laboratory. The accelerated electrons, with energies ranging from 280 to 720 MeV, will collide with a high power laser to produce tunable high energy photons (0.2-20MeV ) with high intensity (10e13 photons/s), high brilliance and spectral purity (0.1% BW), through the Compton backscattering process. This light source will be open to users for nuclear photonics and nuclear physics advanced experiments. Tested high level applications will play an important role in commissioning and operation. In this paper we report the progress and status of the development of dedicated high level applications. We also present the results of the test on the FERMI LINAC of the electron trajectory control method based on Dispersion Free Steering.
We describe a double-scattering experiment with a novel tagged neutron beam to measure differential cross sections for np back-scattering to better than 2% absolute precision. The measurement focuses on angles and energies where the cross section magnitude and angle-dependence constrain the charged pion-nucleon coupling constant, but existing data show serious discrepancies among themselves and with energy-dependent partial wave analyses (PWA). The present results are in good accord with the PWA, but deviate systematically from other recent measurements.
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