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Register a new userOn the persistence and global stability of mass-action systems
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Authors
Casian Pantea
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This paper concerns the long-term behavior of population systems, and in particular of chemical reaction systems, modeled by deterministic mass-action kinetics. We approach two important open problems in the field of Chemical Reaction Network Theory, the Persistence Conjecture and the Global Attractor Conjecture. We study the persistence of a large class of networks called lower-endotactic and in particular, we show that in weakly reversible mass-action systems with two-dimensional stoichiometric subspace all bounded trajectories are persistent. Moreover, we use these ideas to show that the Global Attractor Conjecture is true for systems with three-dimensional stoichiometric subspace.
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Persistence and permanence are properties of dynamical systems that describe the long-term behavior of the solutions, and in particular specify whether positive solutions approach the boundary of the positive orthant. Mass-action systems (or more generally power-law systems) are very common in chemistry, biology, and engineering, and are often used to describe the dynamics in interaction networks. We prove that two-species mass-action systems derived from weakly reversible networks are both persistent and permanent, for any values of the reaction rate parameters. Moreover, we prove that a larger class of networks, called endotactic networks, also give rise to permanent systems, even if we allow the reaction rate parameters to vary in time. These results also apply to power-law systems and other nonlinear dynamical systems. In addition, ideas behind these results allow us to prove the Global Attractor Conjecture for three-species systems.
In this paper, we discuss delayed periodic dynamical systems, compare capability of criteria of global exponential stability in terms of various $L^{p}$ ($1le p<infty$) norms. A general approach to investigate global exponential stability in terms of various $L^{p}$ ($1le p<infty$) norms is given. Sufficient conditions ensuring global exponential stability are given, too. Comparisons of various stability criteria are given. More importantly, it is pointed out that sufficient conditions in terms of $L^{1}$ norm are enough and easy to implement in practice.
We introduce the notion of corresponding a chemical reaction network to a split network translation, and use this novel process to extend the scope of existing network-based theory for characterizing the steady state set of mass-action systems. In the process of network splitting, the reactions of a network are divided into subnetworks, called slices, in such a way that, when summed across the slices, the stoichiometry of each reaction sums to that of the original network. This can produce a network with more desirable structural properties, such as weak reversibility and a lower deficiency, which can then be used to establish steady state properties of the original mass-action system such as multistationarity and absolute concentration robustness. We also present a computational implementation utilizing mixed-integer linear programming for determining whether a given chemical reaction network has a weakly reversible split network translation.
Multidimensional persistence modules do not admit a concise representation analogous to that provided by persistence diagrams for real-valued functions. However, there is no obstruction for multidimensional persistent Betti numbers to admit one. Therefore, it is reasonable to look for a generalization of persistence diagrams concerning those properties that are related only to persistent Betti numbers. In this paper, the persistence space of a vector-valued continuous function is introduced to generalize the concept of persistence diagram in this sense. The main result is its stability under function perturbations: any change in vector-valued functions implies a not greater change in the Hausdorff distance between their persistence spaces.
Motivated by the fact that the pseudo-Helmholtz function is a valid Lyapunov function for characterizing asymptotic stability of complex balanced mass action systems (MASs), this paper develops the generalized pseudo-Helmholtz function for stability analysis for more general MASs assisted with conservation laws. The key technique is to transform the original network into two different MASs, defined by reconstruction and reverse reconstruction, with an important aspect that the dynamics of the original network for free species is equivalent to that of the reverse reconstruction. Stability analysis of the original network is then conducted based on an analysis of how stability properties are retained from the original network to the reverse reconstruction. We prove that the reverse reconstruction possesses only an equilibrium in each positive stoichiometric compatibility class if the corresponding reconstruction is complex balanced. Under this complex balanced reconstruction strategy, the asymptotic stability of the reverse reconstruction, which also applies to the original network, is thus reached by taking the generalized pseudo-Helmholtz function as the Lyapunov function. To facilitate applications, we further provide a systematic method for computing complex balanced reconstructions assisted with conservation laws. Some representative examples are presented to exhibit the validity of the complex balanced reconstruction strategy.
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