Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userICA-based sparse feature recovery from fMRI datasets
212
0
0.0
(
0
)
Added by
Gael Varoquaux
Publication date
2010
fields
Mathematical Statistics
and research's language is
English
Authors
Gael Varoquaux
Ask ChatGPT about the research
No Arabic abstract
Spatial Independent Components Analysis (ICA) is increasingly used in the context of functional Magnetic Resonance Imaging (fMRI) to study cognition and brain pathologies. Salient features present in some of the extracted Independent Components (ICs) can be interpreted as brain networks, but the segmentation of the corresponding regions from ICs is still ill-controlled. Here we propose a new ICA-based procedure for extraction of sparse features from fMRI datasets. Specifically, we introduce a new thresholding procedure that controls the deviation from isotropy in the ICA mixing model. Unlike current heuristics, our procedure guarantees an exact, possibly conservative, level of specificity in feature detection. We evaluate the sensitivity and specificity of the method on synthetic and fMRI data and show that it outperforms state-of-the-art approaches.
rate research
Read More
The primordial power spectrum is an indirect probe of inflation or other structure-formation mechanisms. We introduce a new method, named textbf{PRISM}, to estimate this spectrum from the empirical cosmic microwave background (CMB) power spectrum. This is a sparsity-based inversion method, which leverages a sparsity prior on features in the primordial spectrum in a wavelet dictionary to regularise the inverse problem. This non-parametric approach is able to reconstruct the global shape as well as localised features of spectrum accurately and proves to be robust for detecting deviations from the currently favoured scale-invariant spectrum. We investigate the strength of this method on a set of WMAP nine-year simulated data for three types of primordial spectra and then process the WMAP nine-year data as well as the Planck PR1 data. We find no significant departures from a near scale-invariant spectrum.
Independent component analysis (ICA), as a data driven method, has shown to be a powerful tool for functional magnetic resonance imaging (fMRI) data analysis. One drawback of this multivariate approach is, that it is not compatible to the analysis of group data in general. Therefore various techniques have been proposed in order to overcome this limitation of ICA. In this paper a novel ICA-based work-flow for extracting resting state networks from fMRI group studies is proposed. An empirical mode decomposition (EMD) is used to generate reference signals in a data driven manner, which can be incorporated into a constrained version of ICA (cICA), what helps to eliminate the inherent ambiguities of ICA. The results of the proposed workflow are then compared to those obtained by a widely used group ICA approach for fMRI analysis. In this paper it is demonstrated that intrinsic modes, extracted by EMD, are suitable to serve as references for cICA to obtain typical resting state patterns, which are consistent over subjects. By introducing these reference signals into the ICA, our processing pipeline makes it transparent for the user, how comparable activity patterns across subjects emerge. This additionally allows adapting the trade-off between enforcing similarity across subjects and preserving individual subject features.
Independent Component Analysis (ICA) is an effective unsupervised tool to learn statistically independent representation. However, ICA is not only sensitive to whitening but also difficult to learn an over-complete basis. Consequently, ICA with soft Reconstruction cost(RICA) was presented to learn sparse representations with over-complete basis even on unwhitened data. Whereas RICA is infeasible to represent the data with nonlinear structure due to its intrinsic linearity. In addition, RICA is essentially an unsupervised method and can not utilize the class information. In this paper, we propose a kernel ICA model with reconstruction constraint (kRICA) to capture the nonlinear features. To bring in the class information, we further extend the unsupervised kRICA to a supervised one by introducing a discrimination constraint, namely d-kRICA. This constraint leads to learn a structured basis consisted of basis vectors from different basis subsets corresponding to different class labels. Then each subset will sparsely represent well for its own class but not for the others. Furthermore, data samples belonging to the same class will have similar representations, and thereby the learned sparse representations can take more discriminative power. Experimental results validate the effectiveness of kRICA and d-kRICA for image classification.
Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment remain a major limitation in conducting group analyses and performing population-level inference. This paper addresses this problem by developing and validating a new computational technique for reducing misalignment across individuals in functional brain systems by spatially transforming each subjects functional data to a common reference map. Our proposed Bayesian functional registration approach allows us to assess differences in brain function across subjects and individual differences in activation topology. It combines intensity-based and feature-based information into an integrated framework and allows inference to be performed on the transformation via the posterior samples. We evaluate the method in a simulation study and apply it to data from a study of thermal pain. We find that the proposed approach provides increased sensitivity for group-level inference.
Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of cerebral blood flow. However, ASL data has a lower SNR and resolution so that the recovery of the perfusion response of interest suffers from the contamination by a stronger hemodynamic component in the ASL signal. In this work we consider a model of both hemodynamic and perfusion components within the ASL signal. A physiological link between these two components is analyzed and used for a more accurate estimation of the perfusion response function in particular in the usual ASL low SNR conditions.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
