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Register a new userBayesian Functional Registration of fMRI Data
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Added by
Guoqing Wang
Publication date
2021
fields
Mathematical Statistics
and research's language is
English
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Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment remain a major limitation in conducting group analyses and performing population-level inference. This paper addresses this problem by developing and validating a new computational technique for reducing misalignment across individuals in functional brain systems by spatially transforming each subjects functional data to a common reference map. Our proposed Bayesian functional registration approach allows us to assess differences in brain function across subjects and individual differences in activation topology. It combines intensity-based and feature-based information into an integrated framework and allows inference to be performed on the transformation via the posterior samples. We evaluate the method in a simulation study and apply it to data from a study of thermal pain. We find that the proposed approach provides increased sensitivity for group-level inference.
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Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of cerebral blood flow. However, ASL data has a lower SNR and resolution so that the recovery of the perfusion response of interest suffers from the contamination by a stronger hemodynamic component in the ASL signal. In this work we consider a model of both hemodynamic and perfusion components within the ASL signal. A physiological link between these two components is analyzed and used for a more accurate estimation of the perfusion response function in particular in the usual ASL low SNR conditions.
In order to implement disease-specific interventions in young age groups, policy makers in low- and middle-income countries require timely and accurate estimates of age- and cause-specific child mortality. High quality data is not available in settings where these interventions are most needed, but there is a push to create sample registration systems that collect detailed mortality information. Current methods that estimate mortality from this data employ multistage frameworks without rigorous statistical justification that separately estimate all-cause and cause-specific mortality and are not sufficiently adaptable to capture important features of the data. We propose a flexible Bayesian modeling framework to estimate age- and cause-specific child mortality from sample registration data. We provide a theoretical justification for the framework, explore its properties via simulation, and use it to estimate mortality trends using data from the Maternal and Child Health Surveillance System in China.
We propose a Bayesian nonparametric approach to modelling and predicting a class of functional time series with application to energy markets, based on fully observed, noise-free functional data. Traders in such contexts conceive profitable strategies if they can anticipate the impact of their bidding actions on the aggregate demand and supply curves, which in turn need to be predicted reliably. Here we propose a simple Bayesian nonparametric method for predicting such curves, which take the form of monotonic bounded step functions. We borrow ideas from population genetics by defining a class of interacting particle systems to model the functional trajectory, and develop an implementation strategy which uses ideas from Markov chain Monte Carlo and approximate Bayesian computation techniques and allows to circumvent the intractability of the likelihood. Our approach shows great adaptation to the degree of smoothness of the curves and the volatility of the functional series, proves to be robust to an increase of the forecast horizon and yields an uncertainty quantification for the functional forecasts. We illustrate the model and discuss its performance with simulated datasets and on real data relative to the Italian natural gas market.
With the wide adoption of functional magnetic resonance imaging (fMRI) by cognitive neuroscience researchers, large volumes of brain imaging data have been accumulated in recent years. Aggregating these data to derive scientific insights often faces the challenge that fMRI data are high-dimensional, heterogeneous across people, and noisy. These challenges demand the development of computational tools that are tailored both for the neuroscience questions and for the properties of the data. We review a few recently developed algorithms in various domains of fMRI research: fMRI in naturalistic tasks, analyzing full-brain functional connectivity, pattern classification, inferring representational similarity and modeling structured residuals. These algorithms all tackle the challenges in fMRI similarly: they start by making clear statements of assumptions about neural data and existing domain knowledge, incorporating those assumptions and domain knowledge into probabilistic graphical models, and using those models to estimate properties of interest or latent structures in the data. Such approaches can avoid erroneous findings, reduce the impact of noise, better utilize known properties of the data, and better aggregate data across groups of subjects. With these successful cases, we advocate wider adoption of explicit model construction in cognitive neuroscience. Although we focus on fMRI, the principle illustrated here is generally applicable to brain data of other modalities.
The Argo data is a modern oceanography dataset that provides unprecedented global coverage of temperature and salinity measurements in the upper 2,000 meters of depth of the ocean. We study the Argo data from the perspective of functional data analysis (FDA). We develop spatio-temporal functional kriging methodology for mean and covariance estimation to predict temperature and salinity at a fixed location as a smooth function of depth. By combining tools from FDA and spatial statistics, including smoothing splines, local regression, and multivariate spatial modeling and prediction, our approach provides advantages over current methodology that consider pointwise estimation at fixed depths. Our approach naturally leverages the irregularly-sampled data in space, time, and depth to fit a space-time functional model for temperature and salinity. The developed framework provides new tools to address fundamental scientific problems involving the entire upper water column of the oceans such as the estimation of ocean heat content, stratification, and thermohaline oscillation. For example, we show that our functional approach yields more accurate ocean heat content estimates than ones based on discrete integral approximations in pressure. Further, using the derivative function estimates, we obtain a new product of a global map of the mixed layer depth, a key component in the study of heat absorption and nutrient circulation in the oceans. The derivative estimates also reveal evidence for density
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