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Register a new userA Hybrid Multi Objective Particle Swarm Optimization Method to Discover Biclusters in Microarray Data
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R Doomun
Publication date
2009
fields
Informatics Engineering
and research's language is
English
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In recent years, with the development of microarray technique, discovery of useful knowledge from microarray data has become very important. Biclustering is a very useful data mining technique for discovering genes which have similar behavior. In microarray data, several objectives have to be optimized simultaneously and often these objectives are in conflict with each other. A Multi Objective model is capable of solving such problems. Our method proposes a Hybrid algorithm which is based on the Multi Objective Particle Swarm Optimization for discovering biclusters in gene expression data. In our method, we will consider a low level of overlapping amongst the biclusters and try to cover all elements of the gene expression matrix. Experimental results in the bench mark database show a significant improvement in both overlap among biclusters and coverage of elements in the gene expression matrix.
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We consider an optimization deployment problem of multistatic radar system (MSRS). Through the antenna placing and the transmitted power allocating, we optimally deploy the MSRS for two goals: 1) the first one is to improve the coverage ratio of surveillance region; 2) the second goal is to get a even distribution of signal energy in surveillance region. In two typical working modes of MSRS, we formulate the optimization problem by introducing two objective functions according to the two mentioned goals, respectively. Addressing on two main challenges of applying multi-objective particle swarm optimization (MOPSO) in solving the proposed optimization problem, we propose a deployment algorithm based on multiobjective particle swarm optimization with non-dominated relative crowding distance (MOPSO-NRCD). For the challenge of value difference, we propose a novel selection method with a non-dominated relative crowding distance. For the challenge of particle allocation, a multi-swarm structure of MOPSO is also introduced. Finally, simulation results are given out to prove the advantages and validity of the proposed deployment algorithm. It is shown that with same number of employed particles, the proposed MOPSO-NRCD algorithm can achieve better optimization performance than that of traditional multiobjective particle swarm optimization with crowding distance (MOPSO-CD).
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Machine learning techniques have been developed to learn from complete data. When missing values exist in a dataset, the incomplete data should be preprocessed separately by removing data points with missing values or imputation. In this paper, we propose an online approach to handle missing values while a classification model is learnt. To reach this goal, we develop a multi-objective optimization model with two objective functions for imputation and model selection. We also propose three formulations for imputation objective function. We use an evolutionary algorithm based on NSGA II to find the optimal solutions as the Pareto solutions. We investigate the reliability and robustness of the proposed model using experiments by defining several scenarios in dealing with missing values and classification. We also describe how the proposed model can contribute to medical informatics. We compare the performance of three different formulations via experimental results. The proposed model results get validated by comparing with a comparable literature.
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