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Register a new userSimultaneous confidence intervals for the population cell means, for two-by-two factorial data, that utilize uncertain prior information
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Added by
Paul Kabaila
Publication date
2012
fields
Mathematical Statistics
and research's language is
English
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Consider a two-by-two factorial experiment with more than 1 replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the 4 population cell means, with simultaneous confidence coefficient 1-alpha, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukeys method, with simultaneous confidence coefficient 1-alpha, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.
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Consider panel data modelled by a linear random intercept model that includes a time-varying covariate. Suppose that we have uncertain prior information that this covariate is exogenous. We present a new confidence interval for the slope parameter that utilizes this uncertain prior information. This interval has minimum coverage probability very close to its nominal coverage. Let the scaled expected length of this new confidence interval be its expected length divided by the expected length of the confidence interval, with the same minimum coverage, constructed using the fixed effects model. This new interval has scaled expected length that (a) is substantially less than 1 when the prior information is correct, (b) has a maximum value that is not too much larger than 1 and (c) is close to 1 when the data strongly contradict the prior information. We illustrate the properties of this new interval using an airfare data set.
We consider a general regression model, without a scale parameter. Our aim is to construct a confidence interval for a scalar parameter of interest $theta$ that utilizes the uncertain prior information that a distinct scalar parameter $tau$ takes the specified value $t$. This confidence interval should have good coverage properties. It should also have scaled expected length, where the scaling is with respect to the usual confidence interval, that (a) is substantially less than 1 when the prior information is correct, (b) has a maximum value that is not too large and (c) is close to 1 when the data and prior information are highly discordant. The asymptotic joint distribution of the maximum likelihood estimators $theta$ and $tau$ is similar to the joint distributions of these estimators in the particular case of a linear regression with normally distributed errors having known variance. This similarity is used to construct a confidence interval with the desired properties by using the confidence interval, computed using the R package ciuupi, that utilizes the uncertain prior information in this particular linear regression case. An important practical application of this confidence interval is to a quantal bioassay carried out to compare two similar compounds. In this context, the uncertain prior information is that the hypothesis of parallelism holds. We provide extensive numerical results that illustrate the properties of this confidence interval in this context.
Consider a linear regression model with n-dimensional response vector, regression parameter beta = (beta_1, ..., beta_p) and independent and identically N(0, sigma^2) distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau = c^T beta - t where c and t are specified. Also suppose that we have uncertain prior information that tau = 0. Part of our evaluation of a frequentist confidence interval for theta is the ratio (expected length of this confidence interval)/(expected length of standard 1-alpha confidence interval), which we call the scaled expected length of this interval. We say that a 1-alpha confidence interval for theta utilizes this uncertain prior information if (a) the scaled expected length of this interval is significantly less than 1 when tau = 0, (b) the maximum value of the scaled expected length is not too much larger than 1 and (c) this confidence interval reverts to the standard 1-alpha confidence interval when the data happen to strongly contradict the prior information. Kabaila and Giri, 2009, JSPI present a new method for finding such a confidence interval. Let hatbeta denote the least squares estimator of beta. Also let hatTheta = a^T hatbeta and hattau = c^T hatbeta - t. Using computations and new theoretical results, we show that the performance of this confidence interval improves as |Corr(hatTheta, hattau)| increases and n-p decreases.
Consider a two-treatment, two-period crossover trial, with responses that are continuous random variables. We find a large-sample frequentist 1-alpha confidence interval for the treatment difference that utilizes the uncertain prior information that there is no differential carryover effect.
We consider a linear regression model with regression parameter beta=(beta_1,...,beta_p) and independent and identically N(0,sigma^2) distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau=c^T beta-t where the vector c and the number t are specified and a and c are linearly independent. Also suppose that we have uncertain prior information that tau = 0. We present a new frequentist 1-alpha confidence interval for theta that utilizes this prior information. We require this confidence interval to (a) have endpoints that are continuous functions of the data and (b) coincide with the standard 1-alpha confidence interval when the data strongly contradicts this prior information. This interval is optimal in the sense that it has minimum weighted average expected length where the largest weight is given to this expected length when tau=0. This minimization leads to an interval that has the following desirable properties. This interval has expected length that (a) is relatively small when the prior information about tau is correct and (b) has a maximum value that is not too large. The following problem will be used to illustrate the application of this new confidence interval. Consider a 2-by 2 factorial experiment with 20 replicates. Suppose that the parameter of interest theta is a specified simple effect and that we have uncertain prior information that the two-factor interaction is zero. Our aim is to find a frequentist 0.95 confidence interval for theta that utilizes this prior information.
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