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Register a new userLarge-Sample Confidence Intervals for the Treatment Difference in a Two-Period Crossover Trial, Utilizing Prior Information
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Added by
Paul Kabaila
Publication date
2008
fields
Mathematical Statistics
and research's language is
English
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Consider a two-treatment, two-period crossover trial, with responses that are continuous random variables. We find a large-sample frequentist 1-alpha confidence interval for the treatment difference that utilizes the uncertain prior information that there is no differential carryover effect.
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We consider a linear regression model with regression parameter beta=(beta_1,...,beta_p) and independent and identically N(0,sigma^2) distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau=c^T beta-t where the vector c and the number t are specified and a and c are linearly independent. Also suppose that we have uncertain prior information that tau = 0. We present a new frequentist 1-alpha confidence interval for theta that utilizes this prior information. We require this confidence interval to (a) have endpoints that are continuous functions of the data and (b) coincide with the standard 1-alpha confidence interval when the data strongly contradicts this prior information. This interval is optimal in the sense that it has minimum weighted average expected length where the largest weight is given to this expected length when tau=0. This minimization leads to an interval that has the following desirable properties. This interval has expected length that (a) is relatively small when the prior information about tau is correct and (b) has a maximum value that is not too large. The following problem will be used to illustrate the application of this new confidence interval. Consider a 2-by 2 factorial experiment with 20 replicates. Suppose that the parameter of interest theta is a specified simple effect and that we have uncertain prior information that the two-factor interaction is zero. Our aim is to find a frequentist 0.95 confidence interval for theta that utilizes this prior information.
Consider a two-by-two factorial experiment with more than 1 replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the 4 population cell means, with simultaneous confidence coefficient 1-alpha, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukeys method, with simultaneous confidence coefficient 1-alpha, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.
Consider X_1,X_2,...,X_n that are independent and identically N(mu,sigma^2) distributed. Suppose that we have uncertain prior information that mu = 0. We answer the question: to what extent can a frequentist 1-alpha confidence interval for mu utilize this prior information?
We consider a linear regression model with regression parameter beta =(beta_1, ..., beta_p) and independent and identically N(0, sigma^2)distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau = c^T beta - t where the vector c and the number t are specified and a and c are linearly independent. Also suppose that we have uncertain prior information that tau = 0. Kabaila and Giri (2009c) present a new frequentist 1-alpha confidence interval for theta that utilizes this prior information. This interval has expected length that (a) is relatively small when the prior information about tau is correct and (b) has a maximum value that is not too large. It coincides with the standard 1-alpha confidence interval (obtained by fitting the full model to the data) when the data strongly contradicts the prior information. At first sight, the computation of this new confidence interval seems to be infeasible. However, by the use of the various computational devices that are presented in detail in the present paper, this computation becomes feasible and practicable.
We study the problem of estimating finite sample confidence intervals of the mean of a normal population under the constraint of differential privacy. We consider both the known and unknown variance cases and construct differentially private algorithms to estimate confidence intervals. Crucially, our algorithms guarantee a finite sample coverage, as opposed to an asymptotic coverage. Unlike most previous differentially private algorithms, we do not require the domain of the samples to be bounded. We also prove lower bounds on the expected size of any differentially private confidence set showing that our the parameters are optimal up to polylogarithmic factors.
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