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Register a new userBuckling and force propagation along intracellular microtubules
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Motivated by recent experiments showing the buckling of microtubules in cells, we study theoretically the mechanical response of, and force propagation along elastic filaments embedded in a non-linear elastic medium. We find that, although embedded microtubules still buckle when their compressive load exceeds the critical value $f_c$ found earlier, the resulting deformation is restricted to a penetration depth that depends on both the non-linear material properties of the surrounding cytoskeleton, as well as the direct coupling of the microtubule to the cytoskeleton. The deformation amplitude depends on the applied load $f$ as $(f- f_c)^{1/2}$. This work shows how the range of compressive force transmission by microtubules can be as large as tens of microns and is governed by the mechanical coupling to the surrounding cytoskeleton.
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This article investigates the large deflection and post-buckling of composite plates by employing the Carrera Unified Formulation (CUF). As a consequence, the geometrically nonlinear governing equations and the relevant incremental equations are derived in terms of fundamental nuclei, which are invariant of the theory approximation order. By using the Lagrange expansion functions across the laminate thickness and the classical finite element (FE) approximation, layer-wise (LW) refined plate models are implemented. The Newton-Raphson linearization scheme with the path-following method based on the arc-length constraint is employed to solve geometrically non-linear composite plate problems. In this study, different composite plates subjected to large deflections/rotations and post-buckling are analyzed, and the corresponding equilibrium curves are compared with the results in the available literature or the traditional FEM-based solutions. The effects of various parameters, such as stacking sequence, number of layers, loading conditions, and edge conditions are demonstrated. The accuracy and reliability of the proposed method for solving the composite plates geometrically nonlinear problems are verified.
We use theory and numerical computation to determine the shape of an axisymmetric fluid membrane with a resistance to bending and constant area. The membrane connects two rings in the classic geometry that produces a catenoidal shape in a soap film. In our problem, we find infinitely many branches of solutions for the shape and external force as functions of the separation of the rings, analogous to the infinite family of eigenmodes for the Euler buckling of a slender rod. Special attention is paid to the catenoid, which emerges as the shape of maximal allowable separation when the area is less than a critical area equal to the planar area enclosed by the two rings. A perturbation theory argument directly relates the tension of catenoidal membranes to the stability of catenoidal soap films in this regime. When the membrane area is larger than the critical area, we find additional cylindrical tether solutions to the shape equations at large ring separation, and that arbitrarily large ring separations are possible. These results apply for the case of vanishing Gaussian curvature modulus; when the Gaussian curvature modulus is nonzero and the area is below the critical area, the force and the membrane tension diverge as the ring separation approaches its maximum value. We also examine the stability of our shapes and analytically show that catenoidal membranes have markedly different stability properties than their soap film counterparts.
We investigate how forces spread through frictionless granular packs at the jamming transition. Previous work has indicated that such packs are isostatic, and thus obey a null stress law which, independent of the packing history, causes rays of stress to propagate away from a point force at oblique angles. Prior verifications of the null stress law have used a sequential packing method which yields packs with anisotropic packing histories. We create packs without this anisotropy, and then later break the symmetry by adding a boundary. Our isotropic packs are very sensitive, and their responses to point forces diverge wildly, indicating that they cannot be described by any continuum stress model. We stabilize the packs by supplying an additional boundary, which makes the response much more regular. The response of the stabilized packs resembles what one would expect in a hyperstatic pack, despite the isostatic bulk. The expected stress rays characteristic of null stress behavior are not present. This suggests that isostatic packs do not need to obey a null stress condition. We argue that the rays may arise instead from more simple geometric considerations, such as preferred contact angles between beads.
We derive a model describing spatio-temporal organization of an array of microtubules interacting via molecular motors. Starting from a stochastic model of inelastic polar rods with a generic anisotropic interaction kernel we obtain a set of equations for the local rods concentration and orientation. At large enough mean density of rods and concentration of motors, the model describes an orientational instability. We demonstrate that the orientational instability leads to the formation of vortices and (for large density and/or kernel anisotropy) asters seen in recent experiments. We derive the specific form of the interaction kernel from the detailed analysis of microscopic interaction of two filaments mediated by a moving molecular motor, and extend our results to include variable motor density and motor attachment to the substrate.
We propose an analytical model for the force-indentation relationship in viscoelastic materials exhibiting a power law relaxation described by an exponent n, where n = 1 represents the standard viscoelastic solid (SLS) model, and n < 1 represents a fractional SLS model. To validate the model, we perform nanoindentation measurements of poylacrylamide gels with atomic force microscopy (AFM) force curves. We found exponents n < 1 that depends on the bysacrylamide concentration. We also demonstrate that the fitting of AFM force curves for varying load speeds can reproduce the dynamic viscoelastic properties of those gels measured with dynamic force modulation methods.
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