We present transport measurements along the least conducting c direction of the organic superconductor (TMTSF)2ClO4, performed under an accurately aligned magnetic field in the low temperature regime. The experimental results reveal a two-dimensional confinement of the carriers in the (a,b) planes which is governed by the magnetic field component along the b direction. This 2-D confinement is accompanied by a metal-insulator transition for the c axis resistivity. These data are supported by a quantum mechanical calculation of the transverse transport taking into account in self consistent treatment the effect of the field on the interplane Green function and on the intraplane scattering time.