We show how q-Virasoro constraints can be derived for a large class of (q,t)-deformed eigenvalue matrix models by an elementary trick of inserting certain q-difference operators under the integral, in complete analogy with full-derivative insertions for beta-ensembles. From free-field point of view the models considered have zero momentum of the highest weight, which leads to an extra constraint T_{-1} Z = 0. We then show how to solve these q-Virasoro constraints recursively and comment on the possible applications for gauge theories, for instance calculation of (supersymmetric) Wilson loop averages in gauge theories on D^2 cross S^1 and S^3.
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