Based on the precision experimental data of energy-level differences in hydrogenlike atoms, especially the 1S-2S transition of hydrogen and deuterium, the necessity of establishing a reduced Dirac equation (RDE) with reduced mass as the substitution of original electron mass is stressed. The theoretical basis of RDE lies on two symmetries, the invariance under the space-time inversion and that under the pure space inversion. Based on RDE and within the framework of quantum electrodynamics in covariant form, the Lamb shift can be evaluated (at one-loop level) as the radiative correction on a bound electron staying in an off-mass-shell state--a new approach eliminating the infrared divergence. Hence the whole calculation, though with limited accuracy, is simplified, getting rid of all divergences and free of ambiguity.
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