The isospin properties of primary and secondary fragments produced in multifragmentation of Fe + Ni and Fe + Fe systems with respect to Ni + Ni system are analyzed within the statistical multifragmentation model framework. The reduced neutron and proton densities show an asymmetry in the primary fragments, that is lessened after secondary decay. with increasing isospin (N/Z) this effect increases, while the sensitivity of fragment isospin towards excitation energy and N/Z of the primary fragments remains unchanged.